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Pacific Populations, Metabolic Disease and ‘Just‐So Stories’: A Critique of the ‘Thrifty Genotype’ Hypothesis in Oceania

Pacific Populations, Metabolic Disease and ‘Just‐So Stories’: A Critique of the ‘Thrifty... Summary Pacific populations have long been observed to suffer a high burden of metabolic disease, including obesity, type 2 diabetes and gout. The ‘Thrifty Genotype’ hypothesis has frequently been used to explain this high prevalence of disease. Here, the ‘Thrifty Genotype’ hypothesis and the evolutionary background of Pacific populations are examined. We question its relevance not only in the Pacific region but more generally. Not only has the hypothesis not been explicitly tested, but most archaeological and anthropological data from the Pacific fundamentally do not support its application. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Pacific Populations, Metabolic Disease and ‘Just‐So Stories’: A Critique of the ‘Thrifty Genotype’ Hypothesis in Oceania

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References (121)

Publisher
Wiley
Copyright
Copyright © 2015 John Wiley & Sons Ltd/University College London
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/ahg.12132
pmid
26420513
Publisher site
See Article on Publisher Site

Abstract

Summary Pacific populations have long been observed to suffer a high burden of metabolic disease, including obesity, type 2 diabetes and gout. The ‘Thrifty Genotype’ hypothesis has frequently been used to explain this high prevalence of disease. Here, the ‘Thrifty Genotype’ hypothesis and the evolutionary background of Pacific populations are examined. We question its relevance not only in the Pacific region but more generally. Not only has the hypothesis not been explicitly tested, but most archaeological and anthropological data from the Pacific fundamentally do not support its application.

Journal

Annals of Human GeneticsWiley

Published: Nov 1, 2015

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