Access the full text.
Sign up today, get DeepDyve free for 14 days.
P. Zimmet, G. Dowse, C. Finch, S. Serjeantson, H. King (1990)
The epidemiology and natural history of NIDDM--lessons from the South Pacific.Diabetes/metabolism reviews, 6 2
G. Stratigopoulos, C. Leduc, N. Matsuoka, R. Gutman, Richard Rausch, Scott Robertson, M. Myers, W. Chung, S. Chua, R. Leibel (2009)
Functional Consequences of the Human Leptin Receptor (LEPR) Q223R TransversionObesity, 17
S. Bedford, M. Spriggs, R. Regenvanu (2006)
The Teouma Lapita site and the early human settlement of the Pacific IslandsAntiquity, 80
C. Viscoli, G. Ferrea, G. Agnese, E. Bertorello (1983)
[Hereditary fructose intolerance].La Pediatria medica e chirurgica : Medical and surgical pediatrics, 5 1-2
J. Field, Peter Lape (2010)
Paleoclimates and the emergence of fortifications in the tropical Pacific islandsJournal of Anthropological Archaeology, 29
I. Prior, B. Rose, H. Harvey, F. Davidson (1966)
Hyperuricaemia, gout, and diabetic abnormality in Polynesian people.Lancet, 1 7433
B. Swinburn, SJ Ley, H. Carmichael, L. Plank (1999)
Body size and composition in PolynesiansInternational Journal of Obesity, 23
Takuro Furusawa, I. Naka, T. Yamauchi, K. Natsuhara, R. Kimura, M. Nakazawa, T. Ishida, T. Inaoka, Y. Matsumura, Y. Ataka, N. Nishida, N. Tsuchiya, R. Ohtsuka, J. Ohashi (2010)
The Q223R polymorphism in LEPR is associated with obesity in Pacific IslandersHuman Genetics, 127
J. Diamond (2003)
The double puzzle of diabetesNature, 423
G. Summerhayes, E. Matisoo-Smith, H. Mandui, Jim Allen, J. Specht, N. Hogg, S. McPherson (2010)
Tamuarawai (EQS ): An Early Lapita Site on Emirau, New Ireland, PNGJournal of Pacific archaeology, 1
K. Collerson, M. Weisler (2007)
Stone Adze Compositions and the Extent of Ancient Polynesian Voyaging and TradeScience, 317
S. Starr, K. Jameson, Annu Hogquist, Rev, J Roose, M. Mollenauer, V. Gupta, J. Stone, A. Weiss, L Berg, L. Finkelstein, J. Lucas, P. Schwartzberg, M Fukuda, T. Kojima, H. Kabayama, K. Mikoshiba, J. Biol, K Ching, Y. Kawakami, T. Kawakami, C. Tsoukas, A Guse, E. Greiner, F. Emmrich, K. Brand, Alberola-Ila, A. Altman, N. Gascoigne, G. Koretzky, L. Min, K. Mowen, R. Reisfeld, C. Schmedt, T. Frayling, N. Timpson, M. Weedon, E. Zeggini, R. Freathy, C. Lindgren, J. Perry, K. Elliott, H. Lango, N. Rayner, B. Shields, L. Harries, J. Barrett, S. Ebrahim, D. Lawlor, S. Ring, Y. Ben-Shlomo, L. Ferrucci, R. Loos, C. Palmer
References and Notes Supporting Online Material Materials and Methods Som Text Figs. S1 to S7 References a Common Variant in the Fto Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity
M. Kayser, S. Brauer, Richard Cordaux, A. Casto, O. Lao, L. Zhivotovsky, Claire Moyse-Faurie, R. Rutledge, W. Schiefenhoevel, David Gil, A. Lin, P. Underhill, P. Oefner, R. Trent, M. Stoneking (2006)
Melanesian and Asian origins of Polynesians: mtDNA and Y chromosome gradients across the Pacific.Molecular biology and evolution, 23 11
Á. Montenegro, R. Callaghan, S. Fitzpatrick (2014)
From west to east: Environmental influences on the rate and pathways of Polynesian colonizationThe Holocene, 24
J. Speakman, K. Westerterp (2012)
A mathematical model of weight loss under total starvation: evidence against the thrifty-gene hypothesisDisease Models & Mechanisms, 6
V. Corrales-Medina, Josemon Valayam, J. Serpa, A. Rueda, D. Musher (2011)
The obesity paradox in community-acquired bacterial pneumonia.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 15 1
V. Steinthorsdottir, G. Thorleifsson, I. Reynisdottir, R. Benediktsson, T. Jonsdottir, G. Walters, U. Styrkársdóttir, S. Gretarsdottir, V. Emilsson, Shyamali Ghosh, A. Baker, S. Snorradóttir, Hjordis Bjarnason, M. Ng, T. Hansen, Y. Bagger, R. Wilensky, M. Reilly, A. Adeyemo, Yuanxiu Chen, Jie Zhou, V. Gudnason, Guanjie Chen, Hanxia Huang, K. Lashley, A. Doumatey, W. So, R. Ma, G. Andersen, K. Borch-Johnsen, K. Borch-Johnsen, T. Jørgensen, J. Vliet-Ostaptchouk, M. Hofker, M. Hofker, C. Wijmenga, C. Christiansen, D. Rader, C. Rotimi, M. Gurney, J. Chan, O. Pedersen, O. Pedersen, G. Sigurdsson, J. Gulcher, U. Thorsteinsdóttir, A. Kong, K. Stefánsson (2007)
A variant in CDKAL1 influences insulin response and risk of type 2 diabetesNature Genetics, 39
J. Kratzer, M. Lanaspa, M. Murphy, Christina Cicerchi, Christina Graves, P. Tipton, E. Ortlund, Richard Johnson, E. Gaucher (2014)
Evolutionary history and metabolic insights of ancient mammalian uricasesProceedings of the National Academy of Sciences, 111
L. Southam, N. Soranzo, N. Soranzo, S. Montgomery, T. Frayling, M. McCarthy, M. McCarthy, I. Barroso, E. Zeggini, E. Zeggini (2009)
Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?Diabetologia, 52
M. Allen (1994)
The Prehistoric Exploration and Colonisation of the Pacific, 29
M. Kayser (2010)
The Human Genetic History of Oceania: Near and Remote Views of DispersalCurrent Biology, 20
(1991)
The Hansel and Gretel syndrome: A critique of Houghton’s cold adaptation hypothesis and an alternative model
J. Speakman (2013)
Evolutionary perspectives on the obesity epidemic: adaptive, maladaptive, and neutral viewpoints.Annual review of nutrition, 33
A. Gosling, E. Matisoo-Smith, T. Merriman (2014)
Hyperuricaemia in the Pacific: why the elevated serum urate levels?Rheumatology International, 34
David Burley, M. Weisler, Jian-xin Zhao (2012)
High Precision U/Th Dating of First Polynesian SettlementPLoS ONE, 7
X. Koh, Xuanyao Liu, Y. Teo (2014)
Can Evidence from Genome-Wide Association Studies and Positive Natural Selection Surveys Be Used to Evaluate the Thrifty Gene Hypothesis in East Asians?PLoS ONE, 9
J. Ohashi, I. Naka, R. Kimura, K. Natsuhara, T. Yamauchi, Takuro Furusawa, M. Nakazawa, Y. Ataka, J. Patarapotikul, P. Nuchnoi, K. Tokunaga, T. Ishida, T. Inaoka, Y. Matsumura, R. Ohtsuka (2007)
FTO polymorphisms in oceanic populationsJournal of Human Genetics, 52
Yin Paradies, Michael Montoya, Stephanie Fullerton (2007)
Racialized Genetics and the Study of Complex Diseases: The Thrifty Genotype RevisitedPerspectives in Biology and Medicine, 50
L. Prior (1981)
Epidemiology of Rheumatic disorders in the Pacific with particular emphasis on hyperuricaemia and gout.Seminars in arthritis and rheumatism, 11 1
Todd Bersaglieri, Pardis Sabeti, N. Patterson, T. Vanderploeg, S. Schaffner, J. Drake, M. Rhodes, D. Reich, J. Hirschhorn (2004)
Genetic signatures of strong recent positive selection at the lactase gene.American journal of human genetics, 74 6
Bersaglieri (2004)
Genetic signatures of strong recent positive selection at the lactase geneAm J Med Genet, 74
H. Buckley (2006)
Bioarchaeology of Southeast Asia: ‘The predators within’: investigating the relationship between malaria and health in the prehistoric Pacific Islands
E. Rush, I. Freitas, L. Plank (2009)
Body size, body composition and fat distribution: comparative analysis of European, Maori, Pacific Island and Asian Indian adultsBritish Journal of Nutrition, 102
S. Myles, R. Lea, J. Ohashi, G. Chambers, Joerg Weiss, E. Hardouin, J. Engelken, D. Macartney-Coxson, D. Eccles, I. Naka, R. Kimura, T. Inaoka, Y. Matsumura, M. Stoneking (2011)
Testing the thrifty gene hypothesis: the Gly482Ser variant in PPARGC1A is associated with BMI in TongansBMC Medical Genetics, 12
M. Eng, S. Luczak, T. Wall (2007)
ALDH2, ADH1B, and ADH1C Genotypes in Asians: A Literature ReviewAlcohol Research & Health, 30
R. Deka, Ling Xu, P. Pal, P. Toelupe, T. Laumoli, Huifeng Xi, Ge Zhang, D. Weeks, S. McGarvey (2009)
A tagging SNP in INSIG2 is associated with obesity-related phenotypes among SamoansBMC Medical Genetics, 10
S. Bedford (2001)
ON THE ROAD OF THE WINDS: AN ARCHAEOLOGICAL HISTORY OF THE PACIFIC ISLANDS BEFORE EUROPEAN CONTACT, by
J. Neel (1962)
Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?American journal of human genetics, 14
S. McGarvey (2016)
THE THRIFTY GENE CONCEPT AND ADIPOSITY STUDIES IN BIOLOGICAL ANTHROPOLOGYJournal of The Polynesian Society, 103
M. Rasmussen, Xiaosen Guo, Yong Wang, K. Lohmueller, Simon Rasmussen, A. Albrechtsen, L. Skotte, S. Lindgreen, M. Metspalu, T. Jombart, T. Kivisild, W. Zhai, A. Eriksson, A. Manica, L. Orlando, F. Vega, S. Tridico, E. Metspalu, Kasper Nielsen, María Ávila-Arcos, J. Moreno-Mayar, Craig Muller, J. Dortch, M. Gilbert, O. Lund, Agata Wesolowska, Monika Karmin, L. Weinert, Bo Wang, Jun Li, S. Tai, Fei Xiao, T. Hanihara, G. Driem, A. Jha, F. Ricaut, P. Knijff, A. Migliano, Irene Romero, K. Kristiansen, D. Lambert, S. Brunak, S. Brunak, P. Forster, B. Brinkmann, Olaf Nehlich, M. Bunce, M. Richards, Ramneek Gupta, C. Bustamante, A. Krogh, R. Foley, M. Lahr, F. Balloux, Thomas Sicheritz-Pontén, R. Villems, R. Nielsen, Jun Wang, E. Willerslev (2011)
An Aboriginal Australian Genome Reveals Separate Human Dispersals into AsiaScience, 334
M. Sande (2003)
Cardiovascular disease in sub-Saharan Africa: a disaster waiting to happen.The Netherlands journal of medicine, 61 2
J. Bindon, P. Baker (1997)
Bergmann's rule and the thrifty genotype.American journal of physical anthropology, 104 2
Rasmus Nielsen (2009)
Adaptionism—30 Years After Gould and Lewontin, 63
Viswanathan Mohan, S. Sandeep, R. Deepa, B. Shah, C. Varghese (2007)
Epidemiology of type 2 diabetes: Indian scenario.The Indian journal of medical research, 125 3
A. Goodman, Debra Martin, G. Armelagos, G. Clark (1984)
Indications of Stress from Bone and Teeth. In: Paleopathology at the Origins of Agriculture
P. Houghton (1990)
The adaptive significance of Polynesian body form.Annals of human biology, 17 1
M. Pigliucci, J. Kaplan (2000)
The fall and rise of Dr Pangloss: adaptationism and the Spandrels paper 20 years later.Trends in ecology & evolution, 15 2
J. Neel (2009)
The "thrifty genotype" in 1998.Nutrition reviews, 57 5 Pt 2
Dyan Sellayah, F. Cagampang, R. Cox (2014)
On the evolutionary origins of obesity: a new hypothesis.Endocrinology, 155 5
W. Howells (1976)
Early Hawaiians: An initial study of skeletal remains from Mokapu, Oahu. By Charles E. Snow. xi + 179 pp., figures, tables, bibliography, index. University Press of Kentucky, Lexington. 1974. $16.75 (cloth)American Journal of Physical Anthropology, 44
C. Hanrahan, J. Golub, L. Mohapi, N. Tshabangu, Tebogo Modisenyane, R. Chaisson, G. Gray, J. McIntyre, N. Martinson (2010)
Body mass index and risk of tuberculosis and deathAIDS, 24
(1982)
The thrifty genotype revisited. In: The genetics of diabetes mellitus
E. Karlsson, D. Kwiatkowski, Pardis Sabeti (2014)
Natural selection and infectious disease in human populationsNature Reviews. Genetics, 15
M. Spriggs (2011)
Archaeology and the Austronesian expansion: where are we now?Antiquity, 85
J. Allen, S. Cheer (1996)
The Non-Thrifty GenotypeCurrent Anthropology, 37
Pardis Sabeti, D. Reich, J. Higgins, Haninah Levine, D. Richter, S. Schaffner, S. Gabriel, J. Platko, N. Patterson, G. McDonald, H. Ackerman, S. Campbell, D. Altshuler, R. Cooper, D. Kwiatkowski, R. Ward, E. Lander (2002)
Detecting recent positive selection in the human genome from haplotype structureNature, 419
L. Beil (2014)
Ancient genes, modern meals: Poking holes in the thrifty gene hypothesisScience News, 186
G. Robbins, Haitao Wen, J. Ting (2014)
Inflammasomes and metabolic disorders: old genes in modern diseases.Molecular cell, 54 2
S. Myles, E. Hradetzky, J. Engelken, O. Lao, P. Nürnberg, R. Trent, Xingyu Wang, M. Kayser, M. Stoneking (2007)
Identification of a candidate genetic variant for the high prevalence of type II diabetes in PolynesiansEuropean Journal of Human Genetics, 15
V. Steinthorsdottir, G. Thorleifsson, P. Sulem, H. Helgason, N. Grarup, A. Sigurdsson, Hafdis Helgadottir, Hrefna Johannsdottir, O. Magnusson, S. Gudjonsson, J. Justesen, M. Harder, M. Jørgensen, C. Christensen, I. Brandslund, A. Sandbæk, T. Lauritzen, H. Vestergaard, A. Linneberg, T. Jørgensen, T. Hansen, M. Daneshpour, M. Fallah, Á. Hreidarsson, G. Sigurdsson, F. Azizi, R. Benediktsson, G. Másson, A. Helgason, A. Kong, D. Gudbjartsson, O. Pedersen, U. Thorsteinsdóttir, K. Stefánsson (2014)
Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetesNature Genetics, 46
S. Gould (1997)
The exaptive excellence of spandrels as a term and prototype.Proceedings of the National Academy of Sciences of the United States of America, 94 20
B. Childs (1988)
Human Biology: An introduction to human evolution, variation, growth, and adaptability
R. Lewontin (1991)
Facts and the Factitious in Natural SciencesCritical Inquiry, 18
B. Billups, Dr Glennerster, B. Harris, A. Iriki, Professor Lamb, O. Siddiqi, M. Tessier-Lavigne, J. Ahringer, Dr Baum, Dr Donaldson, Richard Gardner, J. Gray, K. Gull, E. Meyerowitz, Y. Malhi, P. Raven, Zhuomin Chen, Professor Enright, Peter Goodfellow, M. Malim, Professor Tsui, N. Wald, B. Williamson (2008)
The age and origin of the Pacific islands : a geological overview
H. Buckley (2007)
Possible Gouty Arthritis in Lapita‐Associated Skeletons from Teouma, Efate Island, Central VanuatuCurrent Anthropology, 48
Jonathan Friedlaender, F. Friedlaender, F. Reed, K. Kidd, J. Kidd, G. Chambers, R. Lea, J. Loo, G. Koki, J. Hodgson, D. Merriwether, J. Weber (2008)
The Genetic Structure of Pacific IslandersPLoS Genetics, 4
I. Goodwin, S. Browning, Atholl Anderson (2014)
Climate windows for Polynesian voyaging to New Zealand and Easter IslandProceedings of the National Academy of Sciences, 111
J. Wilmshurst, T. Hunt, C. Lipo, A. Anderson (2010)
High-precision radiocarbon dating shows recent and rapid initial human colonization of East PolynesiaProceedings of the National Academy of Sciences, 108
Jennifer Lowe, Jennifer Lowe, Jennifer Lowe, J. Maller, J. Maller, I. Pe’er, I. Pe’er, B. Neale, B. Neale, B. Neale, J. Salit, E. Kenny, Jessica Shea, Jessica Shea, R. Burkhardt, J. Smith, W. Ji, M. Noel, J. Foo, M. Blundell, Vita Skilling, Laura Garcia, M. Sullivan, Heather Lee, Anna Labek, H. Ferdowsian, S. Auerbach, R. Lifton, R. Lifton, C. Newton‐Cheh, J. Breslow, M. Stoffel, M. Daly, M. Daly, D. Altshuler, J. Friedman, Jeffrey Friedman (2009)
Genome-Wide Association Studies in an Isolated Founder Population from the Pacific Island of KosraePLoS Genetics, 5
J. Speakman (2006)
Thrifty genes for obesity and the metabolic syndrome — time to call off the search?Diabetes & Vascular Disease Research, 3
Peter Wilberfoss (2012)
Cold case: Cold induced vasodilation response, and the origins of Polynesian body morphology as an adaptation to a cold environment
J. Speakman (2008)
Thrifty genes for obesity, an attractive but flawed idea, and an alternative perspective: the ‘drifty gene’ hypothesisInternational Journal of Obesity, 32
J. Speakman (2007)
A nonadaptive scenario explaining the genetic predisposition to obesity: the "predation release" hypothesis.Cell metabolism, 6 1
G. Irwin (2016)
AGAINST, ACROSS AND DOWN THE WIND: A CASE FOR THE SYSTEMATIC EXPLORATION OF THE REMOTE PACIFIC ISLANDS
B. McNab, James Brown (2002)
The Physiological Ecology of Vertebrates: A View from Energetics, 84
Agnar Helgason, S. Pálsson, G. Thorleifsson, S. Grant, V. Emilsson, Steinunn Gunnarsdottir, A. Adeyemo, Yuanxiu Chen, Guanjie Chen, I. Reynisdottir, R. Benediktsson, A. Hinney, T. Hansen, G. Andersen, K. Borch-Johnsen, T. Jørgensen, H. Schäfer, M. Faruque, A. Doumatey, Jie Zhou, R. Wilensky, M. Reilly, D. Rader, Y. Bagger, C. Christiansen, G. Sigurdsson, J. Hebebrand, O. Pedersen, U. Thorsteinsdóttir, J. Gulcher, A. Kong, C. Rotimi, K. Stefánsson (2007)
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolutionNature Genetics, 39
H. Buckley (2011)
Epidemiology of Gout: Perspectives from the PastCurrent Rheumatology Reviews, 7
M. Sande, M. Loeff, A. Aveika, S. Sabally, T. Togun, R. Sarge‐Njie, A. Alabi, A. Jaye, T. Corrah, H. Whittle (2004)
Body Mass Index at Time of HIV Diagnosis: A Strong and Independent Predictor of SurvivalJAIDS Journal of Acquired Immune Deficiency Syndromes, 37
(1970)
Anthropometric grouping analysis of Pacific peoples
S. Fitzpatrick (2007)
Archaeology's Contribution to Island Studies
Bertrand Tseng, E. Giedzinski, Atefeh Izadi, Tatiana Suárez, Mary Lan, Katherine Tran, M. Acharya, G. Nelson, J. Raber, V. Parihar, C. Limoli (2013)
Functional Consequences of
A. Bashashati, Gholamreza Haffari, Jiarui Ding, G. Ha, Kenneth Lui, Jamie Rosner, D. Huntsman, C. Caldas, Samuel Aparicio, Sohrab Shah (2012)
DriverNet: uncovering the impact of somatic driver mutations on transcriptional networks in cancerGenome Biology, 13
Ana Duggan, M. Stoneking (2014)
Recent developments in the genetic history of East Asia and Oceania.Current opinion in genetics & development, 29
Ali (1998)
Hereditary fructose intoleranceJ Med Genet, 35
G. Perry, N. Dominy, Katrina Claw, Arthur Lee, H. Fiegler, R. Redon, John Werner, Fernando Villanea, J. Mountain, R. Misra, N. Carter, Charles Lee, A. Stone (2007)
Diet and the evolution of human amylase gene copy number variationNature Genetics, 39
G. Summerhayes, M. Leavesley, Andrew Fairbairn, H. Mandui, Judith Field, A. Ford, R. Fullagar (2010)
Human Adaptation and Plant Use in Highland New Guinea 49,000 to 44,000 Years AgoScience, 330
Agnar Helgason, Bryndís Yngvadóttir, B. Hrafnkelsson, J. Gulcher, K. Stefánsson (2005)
An Icelandic example of the impact of population structure on association studiesNature Genetics, 37
K. Park, H. Shin, B. Park, H. Cheong, Y. Cho, Hong-Kyu Lee, Jong-Young Lee, Jong-Keuk Lee, B. Oh, K. Kimm (2006)
Polymorphisms in the leptin receptor (LEPR)—putative association with obesity and T2DMJournal of Human Genetics, 51
P. Stover (2006)
Influence of human genetic variation on nutritional requirements.The American journal of clinical nutrition, 83 2
Q. Ayub, L. Moutsianas, Yuan Chen, K. Panoutsopoulou, V. Colonna, Luca Pagani, I. Prokopenko, G. Ritchie, C. Tyler-Smith, M. McCarthy, E. Zeggini, Yali Xue (2014)
Revisiting the thrifty gene hypothesis via 65 loci associated with susceptibility to type 2 diabetes.American journal of human genetics, 94 2
(1956)
Ancient voyagers in the Pacific Wellington: Polynesian Society
D. O’Rourke (2012)
Causes and Consequences of Human Migration: Why do we migrate? A retrospective
P. Houghton (1996)
People of the Great Ocean: Legacy
Frayling Frayling, Timpson Timpson, Weedon Weedon, Zeggini Zeggini, Freathy Freathy, Lindgren Lindgren, Perry Perry, Elliott Elliott, Lango Lango, Rayner Rayner, Shields Shields, Harries Harries, Barrett Barrett, Ellard Ellard, Groves Groves, Knight Knight, Patch Patch, Ness Ness, Ebrahim Ebrahim, Lawlor Lawlor, Ring Ring, Ben‐Shlomo Ben‐Shlomo, Jarvelin Jarvelin, Sovio Sovio, Bennett Bennett, Melzer Melzer, Ferrucci Ferrucci, Loos Loos, Barroso Barroso, Wareham Wareham, Karpe Karpe, Owen Owen, Cardon Cardon, Walker Walker, Hitman Hitman, Palmer Palmer, Doney Doney, Morris Morris, Smith Smith, Consortium Consortium, Hattersley Hattersley, McCarthy McCarthy (2007)
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesityScience, 316
Andreas Wollstein, O. Lao, C. Becker, S. Brauer, R. Trent, P. Nürnberg, M. Stoneking, M. Kayser (2010)
Demographic History of Oceania Inferred from Genome-wide DataCurrent Biology, 20
C. Nkenfou, L. Mekue, Christelle Nana, J. Kuiaté (2013)
Distribution of CCR5-Delta32, CCR5 promoter 59029 A/G, CCR2-64I and SDF1-3’A genetic polymorphisms in HIV-1 infected and uninfected patients in the West Region of CameroonBMC Research Notes, 6
S. Gould, R. Lewontin (1979)
The spandrels of San Marco and the Panglossian paradigm: a critique of the adaptationist programmeProceedings of the Royal Society of London. Series B. Biological Sciences, 205
C. Lumeng, A. Saltiel (2011)
Inflammatory links between obesity and metabolic disease.The Journal of clinical investigation, 121 6
K. O'dea (1992)
Diabetes in Australian Aborigines: impact of the western diet and life styleJournal of Internal Medicine, 232
C. Dina, D. Meyre, S. Gallina, E. Durand, A. Körner, P. Jacobson, L. Carlsson, W. Kiess, V. Vatin, C. Lecoeur, J. Delplanque, Emmanuel Vaillant, F. Pattou, J. Ruiz, J. Weill, C. Lévy‐Marchal, F. Horber, N. Potoczna, S. Hercberg, C. Stunff, P. Bougnères, P. Kovacs, M. Marre, B. Balkau, S. Cauchi, J. Chévre, P. Froguel (2007)
Variation in FTO contributes to childhood obesity and severe adult obesityNature Genetics, 39
Te Hīroa (1938)
Vikings of the sunrise
C. Hales, D. Barker (1992)
Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesisDiabetologia, 35
D. Benyshek, J. Watson (2006)
Exploring the thrifty genotype's food-shortage assumptions: a cross-cultural comparison of ethnographic accounts of food security among foraging and agricultural societies.American journal of physical anthropology, 131 1
A. Prentice (2005)
Early influences on human energy regulation: Thrifty genotypes and thrifty phenotypesPhysiology & Behavior, 86
P. Kirch, D. Swindler, C. Turner (1989)
Human skeletal and dental remains from Lapita sites (1600-500 B.C.) in the Mussau Islands, Melanesia.American journal of physical anthropology, 79 1
C. Snow (1974)
Early Hawaiians: An Initial Study of Skeletal Remains from Mokapu, Oahu
Rebekah Karns, S. Viali, John Tuitele, Guangyun Sun, Hong Cheng, D. Weeks, S. McGarvey, R. Deka (2012)
Common Variants in FTO Are Not Significantly Associated with Obesity‐Related Phenotypes among Samoans of PolynesiaAnnals of Human Genetics, 76
S. Corbett, A. Mcmichael, A. Prentice (2009)
Type 2 diabetes, cardiovascular disease, and the evolutionary paradox of the polycystic ovary syndrome: A fertility first hypothesisAmerican Journal of Human Biology, 21
Karolina Åberg, F. Dai, Guangyun Sun, Ember Keighley, S. Indugula, Sarah Roberts, Qi Zhang, D. Smelser, S. Viali, John Tuitele, Li Jin, R. Deka, D. Weeks, S. McGarvey (2009)
Susceptibility Loci for Adiposity Phenotypes on 8p, 9p, and 16q in American Samoa and SamoaObesity, 17
C. Filozof, Claudio González, M. Sereday, C. Mazza, J. Braguinsky (2001)
Obesity prevalence and trends in Latin‐American countriesObesity Reviews, 2
H. Buckley, N. Tayles, S. Halcrow, Kasey Robb, R. Fyfe (2010)
The People of Wairau Bar: a Re-examinationJournal of Pacific archaeology, 1
Kwiatkowski Kwiatkowski (2005)
How malaria has affected the human genome and what human genetics can teach us about malariaAm J Med Genet, 77
S. Guha, J. Rosenfeld, A. Malhotra, Annette Lee, P. Gregersen, J. Kane, I. Pe’er, A. Darvasi, T. Lencz (2012)
Implications for health and disease in the genetic signature of the Ashkenazi Jewish populationGenome Biology, 13
H. Buckley (2000)
Subadult health and disease in prehistoric Tonga, Polynesia.American journal of physical anthropology, 113 4
H. Buckley, R. Kinaston, S. Halcrow, Aimee Foster, M. Spriggs, S. Bedford (2014)
Scurvy in a tropical paradise? Evaluating the possibility of infant and adult vitamin C deficiency in the Lapita skeletal sample of Teouma, Vanuatu, Pacific islands.International journal of paleopathology, 5
D. Kwiatkowski (2005)
How malaria has affected the human genome and what human genetics can teach us about malaria.American journal of human genetics, 77 2
J. Pickup, M. Crook (1998)
Is Type II diabetes mellitus a disease of the innate immune system?Diabetologia, 41
(1924)
The evolution of Maori clothing
(1996)
The physical anthropology of Polynesia: A review of some cranial and skeletal studies
P. Schliekelman, C. Garner, M. Slatkin (2001)
Natural selection and resistance to HIVNature, 411
(1904)
Notes on the custom of Rahui: Its application and manipulation, as also its supposed powers, its rites, invocations and superstitions
Summary Pacific populations have long been observed to suffer a high burden of metabolic disease, including obesity, type 2 diabetes and gout. The ‘Thrifty Genotype’ hypothesis has frequently been used to explain this high prevalence of disease. Here, the ‘Thrifty Genotype’ hypothesis and the evolutionary background of Pacific populations are examined. We question its relevance not only in the Pacific region but more generally. Not only has the hypothesis not been explicitly tested, but most archaeological and anthropological data from the Pacific fundamentally do not support its application.
Annals of Human Genetics – Wiley
Published: Nov 1, 2015
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.