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Oxidative stress in the airways of children with asthma and allergic rhinitis

Oxidative stress in the airways of children with asthma and allergic rhinitis To cite this article: Celik M, Tuncer A, Soyer OU, Saçkesen C, Tanju Besler H, Kalayci O. Oxidative stress in the airways of children with asthma and allergic rhinitis. Pediatric Allergy Immunology 2012: 23: 556–561. Introduction: Even though it is well known that oxidant stress plays an important role in the pathogenesis of asthma, less is known about allergic rhinitis. Moreover, it is not known whether the co‐existence of the two diseases augments the level of oxidant stress within a united airway concept. Aim: To define the level of oxidative stress in children with asthma and/or allergic rhinitis in nasal and oral exhaled breath condensates (EBC) of children. Method: Children aged 6–18 years with asthma (n = 28), allergic rhinitis (n = 17), asthma and allergic rhinitis (n = 100), and healthy controls (n = 74) were enrolled in the study. Levels of malondialdehyde (MDA) as a marker of oxidative stress and reduced glutathione (GSH) as an antioxidant were measured by High‐Performance Liquid Chromatography in the EBC. Results: Malondialdehyde levels were higher, and GSH levels were lower in all patient groups compared to healthy controls in both nasal and oral EBC samples (p < 0.01) but there were no differences among the different patient groups. Interestingly, oral MDA levels were lower in patients with asthma and allergic rhinitis (17.78 nm (11.62–23.94)) compared to patients with asthma only (25.71 nm (18.81–32.61)) (p < 0.01). Discussion: Both asthma and allergic rhinitis are associated with increased oxidative stress in the airways in children. However, the co‐existence of the two diseases does not augment the oxidant stress further. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Oxidative stress in the airways of children with asthma and allergic rhinitis

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References (32)

Publisher
Wiley
Copyright
© 2012 John Wiley & Sons A/S
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/j.1399-3038.2012.01294.x
pmid
22435922
Publisher site
See Article on Publisher Site

Abstract

To cite this article: Celik M, Tuncer A, Soyer OU, Saçkesen C, Tanju Besler H, Kalayci O. Oxidative stress in the airways of children with asthma and allergic rhinitis. Pediatric Allergy Immunology 2012: 23: 556–561. Introduction: Even though it is well known that oxidant stress plays an important role in the pathogenesis of asthma, less is known about allergic rhinitis. Moreover, it is not known whether the co‐existence of the two diseases augments the level of oxidant stress within a united airway concept. Aim: To define the level of oxidative stress in children with asthma and/or allergic rhinitis in nasal and oral exhaled breath condensates (EBC) of children. Method: Children aged 6–18 years with asthma (n = 28), allergic rhinitis (n = 17), asthma and allergic rhinitis (n = 100), and healthy controls (n = 74) were enrolled in the study. Levels of malondialdehyde (MDA) as a marker of oxidative stress and reduced glutathione (GSH) as an antioxidant were measured by High‐Performance Liquid Chromatography in the EBC. Results: Malondialdehyde levels were higher, and GSH levels were lower in all patient groups compared to healthy controls in both nasal and oral EBC samples (p < 0.01) but there were no differences among the different patient groups. Interestingly, oral MDA levels were lower in patients with asthma and allergic rhinitis (17.78 nm (11.62–23.94)) compared to patients with asthma only (25.71 nm (18.81–32.61)) (p < 0.01). Discussion: Both asthma and allergic rhinitis are associated with increased oxidative stress in the airways in children. However, the co‐existence of the two diseases does not augment the oxidant stress further.

Journal

Pediatric Allergy and Immunology – Wiley

Published: Sep 1, 2012

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