Access the full text.
Sign up today, get DeepDyve free for 14 days.
J. Salas‐Salvado, M. Bullo, N. Babio, M. a Martinez‐Gonzalez, N. Ibarrola‐Jurado, J. Basora, R. Estruch, M. i Covas, D. Corella, F. Aros, V. Ruiz‐Gutierrez, E. Ros (2011)
Reduction in the incidence of type 2 diabetes with the Mediterranean diet: Results of the PREDIMED‐Reus nutrition intervention randomized trial, 34
K. Margolis, P. O’Connor, T. Morgan, J. Buse, R. Cohen, W. Cushman, J. Cutler, G. Evans, H. Gerstein, R. Grimm, E. Lipkin, K. Narayan, M. Riddle, A. Sood, D. Goff (2014)
Outcomes of Combined Cardiovascular Risk Factor Management Strategies in Type 2 Diabetes: The ACCORD Randomized TrialDiabetes Care, 37
P. Dandona, S. Dhindsa, Anil Chandel, A. Chaudhuri (2009)
Hypogonadotropic Hypogonadism in Men with Type 2 DiabetesPostgraduate Medicine, 121
D. Kapoor, E. Goodwin, K. Channer, T. Jones (2006)
Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes.European journal of endocrinology, 154 6
M. Romano (2001)
[Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina. A randomized, double-blind, placebo-controlled study].Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology, 2 2
V. Muraleedharan, H. Marsh, D. Kapoor, K. Channer, T. Jones (2013)
Testosterone deficiency is associated with increased risk of mortality and testosterone replacement improves survival in men with type 2 diabetes.European journal of endocrinology, 169 6
Cockcroft Dw, Gault Mh (1976)
Prediction of Creatinine Clearance from Serum CreatinineNephron, 16
M. Grossmann (2011)
Low testosterone in men with type 2 diabetes: significance and treatment.The Journal of clinical endocrinology and metabolism, 96 8
I. Khripun, S. Vorobyev, I. Belousov, M. Kogan, M. Zitzmann (2018)
Influence of testosterone substitution on glycemic control and endothelial markers in men with newly diagnosed functional hypogonadism and type 2 diabetes mellitus: a randomized controlled trialThe Aging Male, 22
G. Laughlin, E. Barrett-Connor, J. Bergstrom (2008)
Low serum testosterone and mortality in older men.The Journal of clinical endocrinology and metabolism, 93 1
E. Nieschlag, R. Swerdloff, H. Behre, L. Gooren, J. Kaufman, J. Legros, B. Lunenfeld, J. Morley, C. Schulman, Christina Wang, W. Weidner, Frederick Wu (2005)
EAU GuidelinesInvestigation, Treatment and Monitoring of Late-Onset Hypogonadism in Males: ISA, ISSAM, and EAU RecommendationsEuropean Urology, 48
A. Gray, J. Berlin, J. Mckinlay, C. Longcope (1991)
An examination of research design effects on the association of testosterone and male aging: results of a meta-analysis.Journal of clinical epidemiology, 44 7
Ren-dong Zheng, Lin Cao, Wen Cao, X. Chu, Yong-xin Hu, Huifeng Zhang, Juan Xu, Hong-Ping Sun, Weiping Bao, Kemian Liu, Chao Liu (2016)
Risk Factors for Hypogonadism in Male Patients with Type 2 DiabetesJournal of Diabetes Research, 2016
Uk-Prospective-Diabetes-Study-Group (1998)
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)The Lancet, 352
A. Iranmanesh, D. Lawson, J. Veldhuis (2012)
Glucose ingestion acutely lowers pulsatile LH and basal testosterone secretion in men.American journal of physiology. Endocrinology and metabolism, 302 6
D. Kapoor, H. Aldred, S. Clark, K. S. Channer, T. H. Jones (2007)
Clinical and biochemical assessment of hypogonadism in men with type 2 diabetes: Correlations with bioavailable testosterone and visceral adiposity, 30
A. Herrero, M. Marcos, Purificación Galindo, J. Miralles, J. Corrales (2018)
Clinical and biochemical correlates of male hypogonadism in type 2 diabetesAndrology, 6
D. Bouhassira, N. Attal, H. Alchaar, F. Boureau, B. Brochet, J. Bruxelle, G. Cunin, J. Fermanian, P. Giniès, A. Grun-Overdyking, H. Jafari-Schluep, M. Lanteri-Minet, B. Laurent, G. Mick, A. Serrié, D. Valade, E. Vicaut (2005)
Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4)Pain, 114
A. Hayek, Y. Khader, Sahar Jafal, N. Khawaja, A. Robert, K. Ajlouni (2013)
Prevalence of low testosterone levels in men with type 2 diabetes mellitus: a cross-sectional studyJournal of Family & Community Medicine, 20
Juan Frias (2018)
Introduction: Standards of Medical Care in Diabetes—2019Diabetes Care, 42
S. Dhindsa, Michael Miller, C. McWhirter, D. Mager, H. Ghanim, A. Chaudhuri, P. Dandona (2010)
Testosterone Concentrations in Diabetic and Nondiabetic Obese MenDiabetes Care, 33
P. Costanzo, S. Suárez, H. Scaglia, C. Zylbersztein, L. Litwak, P. Knoblovits (2014)
Evaluation of the hypothalamic‐pituitary‐gonadal axis in eugonadal men with type 2 diabetes mellitusAndrology, 2
E. Barrett-Connor, K. Khaw, S. Yen (1990)
Endogenous sex hormone levels in older adult men with diabetes mellitus.American journal of epidemiology, 132 5
(2007)
Association Between Serum Bioavailable Testosterone Concentration and the Ratio of Glycated Albumin to Glycated Hemoglobin in Men With Type 2 Diabetes
T. Ugwu, R. Ikem, B. Kolawole, I. Ezeani (2016)
Clinicopathologic assessment of hypogonadism in men with type 2 diabetes mellitusIndian Journal of Endocrinology and Metabolism, 20
(2018)
6. Glycemic Targets: Standards of Medical Care in Diabetes—2019Diabetes Care, 42
Cong-Yi Wang, E. Nieschlag, R. Swerdloff, H. Behre, W. Hellstrom, L. Gooren, Jean Kaufman, Legros Jj, B. Lunenfeld, A. Morales, J. Morley, C. Schulman, I. Thompson, W. Weidner, Frederick Wu (2008)
Investigation, treatment and monitoring of late-onset hypogonadism in malesEuropean Journal of Endocrinology, 159
M. Grossmann, Merlin Thomas, S. Panagiotopoulos, K. Sharpe, R. MacIsaac, S. Clarke, J. Zajac, G. Jerums (2008)
Low testosterone levels are common and associated with insulin resistance in men with diabetes.The Journal of clinical endocrinology and metabolism, 93 5
W. Knowler, E. Barrett-Connor, S. Fowler, R. Hamman, J. Lachin, Elizabeth Walker, David Nathan (2002)
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.The New England journal of medicine, 346 6
G. Corona, E. Mannucci, L. Petrone, V. Ricca, G. Balercia, R. Mansani, V. Chiarini, R. Giommi, G. Forti, M. Maggi (2006)
Association of hypogonadism and type II diabetes in men attending an outpatient erectile dysfunction clinicInternational Journal of Impotence Research, 18
(2017)
Testosterone: Relationships with Metabolic Disorders in Men—An Observational Study from SPECT-China
Anil Chandel, S. Dhindsa, S. Topiwala, A. Chaudhuri, P. Dandona (2008)
Testosterone Concentration in Young Patients With DiabetesDiabetes Care, 31
S. Bhasin, J. Brito, G. Cunningham, F. Hayes, H. Hodis, A. Matsumoto, P. Snyder, R. Swerdloff, Frederick Wu, Maria Yialamas (2018)
Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline.The Journal of clinical endocrinology and metabolism, 103 5
J. Salas‐Salvadó, M. Bulló, N. Babio, M. Martínez-González, N. Ibarrola-Jurado, J. Basora, R. Estruch, M. Covas, D. Corella, F. Arós, V. Ruíz-Gutiérrez, E. Ros (2010)
Reduction in the Incidence of Type 2 Diabetes With the Mediterranean DietDiabetes Care, 34
S. Dhindsa, S. Prabhakar, M. Sethi, A. Bandyopadhyay, A. Chaudhuri, P. Dandona (2004)
Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes.The Journal of clinical endocrinology and metabolism, 89 11
A. Levey, J. Coresh, K. Bolton, B. Culleton, K. Harvey, T. Ikizler, C. Johnson, A. Kausz, P. Kimmel, J. Kusek, A. Levin, K. Minaker, R. Nelson, H. Rennke, M. Steffes, B. Witten, R. Hogg, S. Furth, K. Lemley, R. Portman, G. Schwartz, J. Lau, E. Balk, R. Perrone, T. Karim, Lara Rayan, Inas Al-Massry, P. Chew, B. Astor, De Vine, G. Eknoyan, N. Levin, S. Burrows‐Hudson, W. Keane, A. Kliger, D. Latos, D. Mapes, E. Oberley, K. Willis, G. Bailie, G. Becker, J. Burrowes, D. Churchill, A. Collins, W. Couser, D. Dezeeuw, A. Garber, T. Golper, F. Gotch, A. Gotto, J. Greer, R. Grimm, R. Hannah, J. Acosta, L. Hunsicker, M. Klag, S. Klahr, C. Lewis, E. Lowrie, A. Matas, S. McCulloch, Maureen Michael, J. Nally, J. Newmann, A. Nissenson, Keith Norris, W. Owen, T. Patel, G. Payne, R. Rivera-Mizzoni, David Smith, R. Star, T. Steinman, F. Valderrábano, J. Walls, J. Wauters, N. Wenger, J. Briggs (2002)
K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification.American journal of kidney diseases : the official journal of the National Kidney Foundation, 39 2 Suppl 1
D. Kapoor, H. Aldred, S. Clark, K. Channer, T. Jones (2007)
Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 DiabetesDiabetes Care, 30
We aimed to evaluate the effects of hypogonadism on metabolic and chronic complications in type 2 diabetic males. 261 nonobese males with type 2 diabetes aged 18–70 were involved in the study. Hypononadal males were divided into 2 groups as overt hypogonadism (total testosterone≤230 ng/dl) and borderline hypogonadism (230–345 ng/dl). The control group involved eugonadal diabetic males. Micro‐macrovascular complications were recorded. 101 patients had hypogonadism (38.7%), and 160 patients were eugonadal (61.3%). Microvascular complication rate was not different, but macrovascular complication rate was significantly higher in hypogonadal males (42.6%/31.3%, p = 0.042). Optimal glycosylated haemoglobin (HbA1c) achievement(<7%) was significantly lower in hypogonadal patients (20.8%/31.3%, p = 0.043). Poor glycaemic control (HbA1c≥7%), presence of microvascular complication and increased triglyceride levels were independent risk factors for hypogonadism (OR: 1.5, p = 0.044;OR:3.89,p = 0.025 and OR: 1.0, p = 0.016 respectively). Overt hypogonadism, hypertension, hypercholesterolaemia and severe hypoglycaemia were independent risk factors for macrovascular complications (OR: 1.0, p = 0.027; OR:2.6, p = 0.002; OR: 1.8, p = 0.047 and OR: 1.0, p = 0.007 respectively), diabetes duration (≥5 years) and poor glycaemic control for microvascular complication (OR: 1.0, p = 0.031 and OR:2.0, p = 0.028). As a result, hypogonadism is frequent among diabetic males and poor glycaemic control may be an important contributing factor. Furthermore overt hypogonadism is an important cardiovascular risk marker. Therefore, ensuring eugonadism in diabetic patients may positively affect both glycaemic control and complications.
Andrologia – Wiley
Published: Feb 1, 2022
Keywords: diabetic chronic complications; glycaemic control; overt hypogonadism
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.