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Overcoming perioperative inflammation as a hurdle for successful preclinical orthotopic cardiac xenogeneic transplantations – particular in regard of the mandatory use of heart‐lung machines

Overcoming perioperative inflammation as a hurdle for successful preclinical orthotopic cardiac... INTRODUCTIONIn the July 2021 issue of this journal, C.P. Thompson et al.1 discussed the “potential detrimental role of inflammation in pig orthotopic heart xenotransplantation.” After dealing with common reactions to porcine tissues, the authors focused on severe pathological responses due to the cardiopulmonary bypass that is necessary to keep the baboon recipients alive during heart replacement, emphasizing the susceptibility of the lungs to injury in this setting. In the concluding section of the commentary, various treatment options were suggested, including anti‐inflammatory therapy and genetic engineering of the donor pig.We are of the opinion, however, that minimizing or even avoiding possible detrimental processes associated with the use of a heart‐lung machine must be preferable. Consequently, the following article will focus on improved cardiosurgical techniques. It is written not only for experts in our field, but also those (including possible investors) who are not necessarily familiar with these surgical issues.PAST AND PRESENT OF HEART‐LUNG MACHINE TECHNOLOGIES IN HUMANSExperimental work on whole‐body perfusion was conducted in the late 1930s by John and Mary Gibbon at the Massachusetts General Hospital, Boston. In their device, which was a huge apparatus twice the size of a refrigerator, a roller‐pump replaced the heart and a grid/screen oxygenator http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Xenotransplantation Wiley

Overcoming perioperative inflammation as a hurdle for successful preclinical orthotopic cardiac xenogeneic transplantations – particular in regard of the mandatory use of heart‐lung machines

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References (23)

Publisher
Wiley
Copyright
© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
ISSN
0908-665X
eISSN
1399-3089
DOI
10.1111/xen.12749
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONIn the July 2021 issue of this journal, C.P. Thompson et al.1 discussed the “potential detrimental role of inflammation in pig orthotopic heart xenotransplantation.” After dealing with common reactions to porcine tissues, the authors focused on severe pathological responses due to the cardiopulmonary bypass that is necessary to keep the baboon recipients alive during heart replacement, emphasizing the susceptibility of the lungs to injury in this setting. In the concluding section of the commentary, various treatment options were suggested, including anti‐inflammatory therapy and genetic engineering of the donor pig.We are of the opinion, however, that minimizing or even avoiding possible detrimental processes associated with the use of a heart‐lung machine must be preferable. Consequently, the following article will focus on improved cardiosurgical techniques. It is written not only for experts in our field, but also those (including possible investors) who are not necessarily familiar with these surgical issues.PAST AND PRESENT OF HEART‐LUNG MACHINE TECHNOLOGIES IN HUMANSExperimental work on whole‐body perfusion was conducted in the late 1930s by John and Mary Gibbon at the Massachusetts General Hospital, Boston. In their device, which was a huge apparatus twice the size of a refrigerator, a roller‐pump replaced the heart and a grid/screen oxygenator

Journal

XenotransplantationWiley

Published: May 1, 2022

Keywords: heart‐lung machine; orthotopic heart transplantation; perioperative inflammation; xenotransplantation

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