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Oral Communication: Clinical (2)

Oral Communication: Clinical (2) 185 The impact of Fcγ receptor polymorphisms on the outcome of ABO‐incompatible living donor liver transplantation Hiroshi Sakai 1 , Yuka Tanaka 1 , Seiichi Shimizu 1 , Kentaro Ide 1 , Hirofumi Tazawa 1 , Yu Sasaki 1 , Masahiro Ohira 1 , Kohei Ishiyama 1 , Tsuyoshi Kobayashi 1 , Hirotaka Tashiro 1 , Hideki Ohdan 1 1 Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan Aim : Rituximab plays an indispensable role in the immunosuppressive regimen following ABO‐incompatible organ transplantation. Recent studies have reported that IgG Fc receptor (FcγR) and C1qA polymorphisms in patients with diffuse large B cell lymphoma play a role in the response to rituximab. The purpose of this study was to explore the impact of these polymorphisms on the clinical responses to rituximab in recipients following ABO‐incompatible liver transplantation (LT). Methods : Eighteen patients who received ABO‐blood type incompatible living donor LT were employed in this study. Rituximab was administered 2 weeks before LT, followed by administration of taclorimus and mycophenolate mofetil. The residual B cell numbers in the peripheral blood and spleen (biopsy samples) were analyzed by flow cytometry to evaluate the therapeutic effect of Rituximab during LT. We determined http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Xenotransplantation Wiley

Oral Communication: Clinical (2)

Xenotransplantation , Volume 20 (5) – Sep 1, 2013
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Publisher
Wiley
Copyright
© 2013 John Wiley & Sons A/S
ISSN
0908-665X
eISSN
1399-3089
DOI
10.1111/xen.12060_5
Publisher site
See Article on Publisher Site

Abstract

185 The impact of Fcγ receptor polymorphisms on the outcome of ABO‐incompatible living donor liver transplantation Hiroshi Sakai 1 , Yuka Tanaka 1 , Seiichi Shimizu 1 , Kentaro Ide 1 , Hirofumi Tazawa 1 , Yu Sasaki 1 , Masahiro Ohira 1 , Kohei Ishiyama 1 , Tsuyoshi Kobayashi 1 , Hirotaka Tashiro 1 , Hideki Ohdan 1 1 Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan Aim : Rituximab plays an indispensable role in the immunosuppressive regimen following ABO‐incompatible organ transplantation. Recent studies have reported that IgG Fc receptor (FcγR) and C1qA polymorphisms in patients with diffuse large B cell lymphoma play a role in the response to rituximab. The purpose of this study was to explore the impact of these polymorphisms on the clinical responses to rituximab in recipients following ABO‐incompatible liver transplantation (LT). Methods : Eighteen patients who received ABO‐blood type incompatible living donor LT were employed in this study. Rituximab was administered 2 weeks before LT, followed by administration of taclorimus and mycophenolate mofetil. The residual B cell numbers in the peripheral blood and spleen (biopsy samples) were analyzed by flow cytometry to evaluate the therapeutic effect of Rituximab during LT. We determined

Journal

Xenotransplantation – Wiley

Published: Sep 1, 2013

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