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An efficient iodine‐mediated aza‐Michael addition/C−H functionalization procedure for the synthesis of indoles was achieved in one pot. By simple aza‐Michael addition between anilines and α,β‐ynones, a series of N‐aryl enaminones intermediate was generated, followed by iodine‐mediated C−H functionalization, a wide variety of indole derivatives were obtained in moderate to excellent yields under transition‐metal‐free conditions. Control experiments and in situ ESI‐MS analysis indicated the reaction occurred via a radical mechanism.
Asian Journal of Organic Chemistry – Wiley
Published: Apr 1, 2019
Keywords: ; ; ; ;
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