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J. Murdoch, B. Walker, V. McKusick (1972)
Parental age effects on the occurrence of new mutations for the Marfan syndromeAnnals of Human Genetics, 35
Loesch Loesch, Lisiewicz Lisiewicz (1974)
The application of discriminant functions in some sex‐chromosomal anomaliesGenet & Polonica, 15
C. Blank (1959)
Apert's syndrome (a type of acrocephalosyndactyly)–observations on a British series of thirty‐nine cases*Annals of Human Genetics, 24
(1974)
The application of discriminant functions in some sex-chromosomal
(1960)
Apert’s syndrome (a type of acrocephalosyndactyly) - observations on a British series LOESCH
(1967)
Multivariate Statistical Methock
Cedric Smith (1972)
Note on the estimation of parental age effectsAnnals of Human Genetics, 35
O. Mayo (1974)
Effect of age on chiasma number in man.Human heredity, 24 2
J. Murdoch, Bryan Walker, J. Hall, Helen Abbey, K. Smith, V. McKusick (1970)
Achondroplasia—a genetic and statistical surveyAnnals of Human Genetics, 33
BY 0. MAYO,* J. L. MURDOCHT AND T. W. HANCOCK* * Biometry Section, Waite Agricultural Research Institute, University of Adelaide, Adelaide, 8outh Australia 5064 t Lorna Linda University, School of Medicine, Lorna Linda, California 92354, U.S.A. For many years, it has been accepted that sporadic cases of certain dominant or semi-dominant mutations are associated with an increased paternal age, but not with increased maternal age or birth rank. However, because maternal age, paternal age, and birth rank are so highly correlated with one another, it has been very difficult to separate the effects, and to produce unequivocal evidence for any particular one being more important. All of the methods in use have certain flaws or difficulties. The best method available, that of Smith (1972), requires that one know population values for the regression of maternal age on birth rank, paternal age on birth rank, maternal age on paternal age, and vice versa (the p matrix below). Smithâs method allows not only the detection but also the estimation of the various effects, but as it requires these population data, it may often not be applicable. It does not seem to have been noticed that a simple discriminant function applied
Annals of Human Genetics – Wiley
Published: May 1, 1976
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