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On some models for segregation analysist†

On some models for segregation analysist† On some models for segregation analysist BY ERIC PERITZ Department of Social Medicine, Hebrew University-Hadassah Medical School and Hadassah Medical Organization The purpose of this paper is to propose some models for segregation analysis somewhat different from those described by Morton (1958, 1959, 1962). The assumptions regarding reproductive behaviour which are implicit in the two types of models will be pointed out. The discussion is limited to situations in which ‘complete ascertainment’ (or ‘complete selection’) prevails, i.e. the inclusion of families in the study is independent of any characteristic of the offspring. The models are formulated in terms of intra-uterine mortality; the possibility of prezygotic selection is neglected. Reference will be made mainly to situations in which dominance is present. (1) Notation The probability of a zygote being of a given genotype depends of course on the genotypes of the parents. We shall assume however that only the phenotypes of the parents are known a priori. The probability of a zygote being of a certain phenotype u, given that the phenotype of the mother is v and that of the father w , will be denoted byp,,, (u,v , w are generic notations for the phenotypes). Suitable modifications http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

On some models for segregation analysist†

PERITZ, ERIC
Annals of Human Genetics , Volume 30 (2) – Nov 1, 1966
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References (10)

Publisher
Wiley
Copyright
Copyright © 1966 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1966.tb00017.x
Publisher site
See Article on Publisher Site

Abstract

On some models for segregation analysist BY ERIC PERITZ Department of Social Medicine, Hebrew University-Hadassah Medical School and Hadassah Medical Organization The purpose of this paper is to propose some models for segregation analysis somewhat different from those described by Morton (1958, 1959, 1962). The assumptions regarding reproductive behaviour which are implicit in the two types of models will be pointed out. The discussion is limited to situations in which ‘complete ascertainment’ (or ‘complete selection’) prevails, i.e. the inclusion of families in the study is independent of any characteristic of the offspring. The models are formulated in terms of intra-uterine mortality; the possibility of prezygotic selection is neglected. Reference will be made mainly to situations in which dominance is present. (1) Notation The probability of a zygote being of a given genotype depends of course on the genotypes of the parents. We shall assume however that only the phenotypes of the parents are known a priori. The probability of a zygote being of a certain phenotype u, given that the phenotype of the mother is v and that of the father w , will be denoted byp,,, (u,v , w are generic notations for the phenotypes). Suitable modifications

Journal

Annals of Human Genetics – Wiley

Published: Nov 1, 1966

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