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On estimating the actual rate of foetal loss in families with an autosomal recessive disorder and Woolf's data on PKU

On estimating the actual rate of foetal loss in families with an autosomal recessive disorder and... On estimating the actual rate of foetal loss in families with an autosomal recessive disorder and Woolf’s data on PKU BY LEO P. TEN KATE Department of Human Genetics, University of Groningen, The Netherlands In my paper ‘A method for analysing fertility of heterozygotes for autosomal recessive disorders, with special reference to cystic fibrosis, Tay-Sachs disease and phenylketonuria ’ (Ten Kate, 1977) I argued that the estimation of foetal loss in families ascertained through children with an autosomal recessive disease is seriously biased unless the data are corrected by appropriate methods. In this context I quoted as an example the results of Woolf et al. (1975), who found a total of 20 (10.8%) spontaneous abortions or stillbirths among 186 pregnancies of 57 mothers with PKU children, compared to 232 (19.2 %) spontaneous abortions or stillbirths among 1213 pregnancies of 412 women delivered at the same time in the same hospitals as the PKU mothers. Dr Woolf, however, pointed out to me in a personal communication that these figures were not the raw data, but corrected results. I n fact, Woolf et al. found a total of 20 (8.0%) spontaneous abortions and stillbirths among 251 pregnancies of 65 mothers http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

On estimating the actual rate of foetal loss in families with an autosomal recessive disorder and Woolf's data on PKU

KATE, LEO P. ten
Annals of Human Genetics , Volume 41 (4) – May 1, 1978
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References (3)

Publisher
Wiley
Copyright
Copyright © 1978 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1978.tb00916.x
Publisher site
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Abstract

On estimating the actual rate of foetal loss in families with an autosomal recessive disorder and Woolf’s data on PKU BY LEO P. TEN KATE Department of Human Genetics, University of Groningen, The Netherlands In my paper ‘A method for analysing fertility of heterozygotes for autosomal recessive disorders, with special reference to cystic fibrosis, Tay-Sachs disease and phenylketonuria ’ (Ten Kate, 1977) I argued that the estimation of foetal loss in families ascertained through children with an autosomal recessive disease is seriously biased unless the data are corrected by appropriate methods. In this context I quoted as an example the results of Woolf et al. (1975), who found a total of 20 (10.8%) spontaneous abortions or stillbirths among 186 pregnancies of 57 mothers with PKU children, compared to 232 (19.2 %) spontaneous abortions or stillbirths among 1213 pregnancies of 412 women delivered at the same time in the same hospitals as the PKU mothers. Dr Woolf, however, pointed out to me in a personal communication that these figures were not the raw data, but corrected results. I n fact, Woolf et al. found a total of 20 (8.0%) spontaneous abortions and stillbirths among 251 pregnancies of 65 mothers

Journal

Annals of Human Genetics – Wiley

Published: May 1, 1978

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