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Numerical analysis of chromosome patterns

Numerical analysis of chromosome patterns Numerical analysis of chromosome patterns BY D. E. BARTON, FLORENCE N. DAVID AND MAXINE MERRINGTON Univerkty College London In three other papers (B&rton& David, 1961 a, b, 1963) criteria have been described in which the distances apart of homologous pairs of chromosomes observed in mitotic figures are standardized by a function of distances between all pairs. These criteria are suggested as appropriate for testing the hypothesis of the randomness of position of the two chromosomes of the homologous pair with respect to each other both in the normal and the abnormal cell. For present purposes, by the normal cell we shall mean a cell which contains 23 pairs of chromosomes. By the abnormal cell here we shall mean one which is aneuploid, i.e. a cell which may contain 46 chromosomes, or more or less than 46, but they will not be classifiable in pairs. Based on a suggestion of Penrose we proposed (Barton & David, 1961a) the L' criterion for the normal cell. For the abnormal cell (Barton & David, 1963) we put forward the T* criterion. T* is identical with L' for the normal cell. Phenotypes have been called normal when they have not been classified as http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Numerical analysis of chromosome patterns

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References (3)

Publisher
Wiley
Copyright
Copyright © 1963 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1963.tb01333.x
Publisher site
See Article on Publisher Site

Abstract

Numerical analysis of chromosome patterns BY D. E. BARTON, FLORENCE N. DAVID AND MAXINE MERRINGTON Univerkty College London In three other papers (B&rton& David, 1961 a, b, 1963) criteria have been described in which the distances apart of homologous pairs of chromosomes observed in mitotic figures are standardized by a function of distances between all pairs. These criteria are suggested as appropriate for testing the hypothesis of the randomness of position of the two chromosomes of the homologous pair with respect to each other both in the normal and the abnormal cell. For present purposes, by the normal cell we shall mean a cell which contains 23 pairs of chromosomes. By the abnormal cell here we shall mean one which is aneuploid, i.e. a cell which may contain 46 chromosomes, or more or less than 46, but they will not be classifiable in pairs. Based on a suggestion of Penrose we proposed (Barton & David, 1961a) the L' criterion for the normal cell. For the abnormal cell (Barton & David, 1963) we put forward the T* criterion. T* is identical with L' for the normal cell. Phenotypes have been called normal when they have not been classified as

Journal

Annals of Human GeneticsWiley

Published: May 1, 1963

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