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NMDA receptor‐independent LTP in basal versus apical dendrites of CA1 pyramidal cells in rat hippocampal slice

NMDA receptor‐independent LTP in basal versus apical dendrites of CA1 pyramidal cells in rat... The ability of hippocampal CA1 basal synapses to express N‐methyl‐D‐aspartate (NMDA) receptor‐independent long‐term potentiation (non‐NMDA LTP) was studied and compared to the simultaneously induced apical dendritic non‐NMDA LTP. Non‐NMDA LTP in basal and apical dendrites was induced using stimulation pattern similar to the sharp wave‐associated CA3 bursts. Basal dendritic non‐NMDA LTP was input‐specific and displayed similar development and magnitude to the apical dendritic non‐NMDA LTP. Both apical and basal dendritic non‐NMDA potentiations were inhibited by the voltage‐dependent calcium channel (VDCC) inhibitor verapamil and the tyrosine kinase inhibitors genistein and levandustin A. However, the difference in the degree and time course of these inhibitions suggests involvement of distinct mechanisms in the two dendritic subfields. Hippocampus 1998;8:373–379. © 1998 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hippocampus Wiley

NMDA receptor‐independent LTP in basal versus apical dendrites of CA1 pyramidal cells in rat hippocampal slice

Hippocampus , Volume 8 (4) – Jan 1, 1998

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References (51)

Publisher
Wiley
Copyright
Copyright © 1998 Wiley Subscription Services
ISSN
1050-9631
eISSN
1098-1063
DOI
10.1002/(SICI)1098-1063(1998)8:4<373::AID-HIPO5>3.0.CO;2-I
Publisher site
See Article on Publisher Site

Abstract

The ability of hippocampal CA1 basal synapses to express N‐methyl‐D‐aspartate (NMDA) receptor‐independent long‐term potentiation (non‐NMDA LTP) was studied and compared to the simultaneously induced apical dendritic non‐NMDA LTP. Non‐NMDA LTP in basal and apical dendrites was induced using stimulation pattern similar to the sharp wave‐associated CA3 bursts. Basal dendritic non‐NMDA LTP was input‐specific and displayed similar development and magnitude to the apical dendritic non‐NMDA LTP. Both apical and basal dendritic non‐NMDA potentiations were inhibited by the voltage‐dependent calcium channel (VDCC) inhibitor verapamil and the tyrosine kinase inhibitors genistein and levandustin A. However, the difference in the degree and time course of these inhibitions suggests involvement of distinct mechanisms in the two dendritic subfields. Hippocampus 1998;8:373–379. © 1998 Wiley‐Liss, Inc.

Journal

HippocampusWiley

Published: Jan 1, 1998

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