Access the full text.
Sign up today, get DeepDyve free for 14 days.
M. Islam (2017)
Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disordersNeurological Research, 39
Yuanbo Wu, Meiqiao Chen, Jielong Jiang (2019)
Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling.Mitochondrion
A. Ivanov, V. Valuev-Elliston, O. Ivanova, S. Kochetkov, E. Starodubova, B. Bartosch, M. Isaguliants (2016)
Oxidative Stress during HIV Infection: Mechanisms and ConsequencesOxidative Medicine and Cellular Longevity, 2016
Jian-Min Chen, Liqiu Tan, Yuan-jun Liao, Jiang-yi Long, Yi-jun Zhou, Jinbin Wei, Yan Zhou (2020)
Chemokine CCL2 impairs spatial memory and cognition in rats via influencing inflammation, glutamate metabolism and apoptosis-associated genes expression- a potential mechanism for HIV-associated neurocognitive disorder.Life sciences
G. Hotamışlıgil, R. Davis (2016)
Cell Signaling and Stress Responses.Cold Spring Harbor perspectives in biology, 8 10
A. Peel (2004)
PKR Activation in Neurodegenerative DiseaseJNEN: Journal of Neuropathology & Experimental Neurology, 63
Y. Hirata, T. Iwasaki, Yukimi Makimura, Sayaka Okajima, K. Oh‐hashi, H. Takemori (2019)
Inhibition of double-stranded RNA-dependent protein kinase prevents oxytosis and ferroptosis in mouse hippocampal HT22 cells.Toxicology, 418
Ankit Shah, N. Vaidya, H. Bhat, Anil Kumar (2016)
HIV-1 gp120 induces type-1 programmed cell death through ER stress employing IRE1α, JNK and AP-1 pathwayScientific Reports, 6
J. Louboutin, D. Strayer (2014)
Role of Oxidative Stress in HIV-1-Associated Neurocognitive Disorder and Protection by Gene Delivery of Antioxidant EnzymesAntioxidants, 3
J. Hugon, F. Mouton-Liger, J. Dumurgier, C. Paquet (2017)
PKR involvement in Alzheimer’s diseaseAlzheimer's Research & Therapy, 9
Yuan-jun Liao, Jian-Min Chen, Jiang-yi Long, Yi-jun Zhou, Bing-yu Liang, Yan Zhou (2020)
Corrigendum to “Tanshinone IIA Alleviates CCL2-Induced Leaning memory and Cognition Impairment in Rats: A Potential Therapeutic Approach for HIV-Associated Neurocognitive Disorder”BioMed Research International, 2020
Nigrostriatal Degeneration (2021)
Mitochondrial DysfunctionEncyclopedia of Gerontology and Population Aging
D. Saylor, A. Dickens, N. Sacktor, N. Haughey, B. Slusher, M. Pletnikov, J. Mankowski, Amanda Brown, D. Volsky, J. McArthur (2016)
HIV-associated neurocognitive disorder — pathogenesis and prospects for treatmentNature Reviews Neurology, 12
Yu Cai, J. Arikkath, Lu Yang, M. Guo, P. Periyasamy, S. Buch (2016)
Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disordersAutophagy, 12
M. Shimazawa, Yasushi Ito, Yuta Inokuchi, H. Hara (2007)
Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage.Investigative ophthalmology & visual science, 48 8
Surojit Paul, J. Connor (2010)
NR2B‐NMDA receptor‐mediated increases in intracellular Ca2+ concentration regulate the tyrosine phosphatase, STEP, and ERK MAP kinase signalingJournal of Neurochemistry, 114
M. Kaneko, K. Imaizumi, A. Saito, S. Kanemoto, R. Asada, Koji Matsuhisa, Y. Ohtake (2017)
ER Stress and Disease: Toward Prevention and Treatment.Biological & pharmaceutical bulletin, 40 9
J. Cummings, G. Tong, C. Ballard (2019)
Treatment Combinations for Alzheimer’s Disease: Current and Future Pharmacotherapy OptionsJournal of Alzheimer's Disease, 67
Ankit Shah, Anil Kumar (2016)
HIV-1 gp120-Mediated Mitochondrial Dysfunction and HIV-Associated Neurological DisordersNeurotoxicity Research, 30
(2004)
Human immunodeficiency virus type 1 glycoprotein gp 120 reduces the levels of brain - derived neurotrophic factor in vivo : Potential implication for neuronal cell death
B. Li, Y. Shi, J. Shu, J. Gao, P. Wu, S. J. Tang (2013)
Wingless‐type mammary tumor virus integration site family, member 5A (Wnt5a) regulates human immunodeficiency virus type 1 (HIV‐1) envelope glycoprotein 120 (gp120)‐induced expression of pro‐inflammatory cytokines via the Ca2+/calmodulin‐dependent protein kinase II (CaMKII) and c‐Jun N‐terminal kinase (JNK) signaling pathways, 288
J. Anzinger, T. Butterfield, T. Angelovich, S. Crowe, Clovis Palmer (2014)
Monocytes as Regulators of Inflammation and HIV-Related Comorbidities during cARTJournal of Immunology Research, 2014
R. Ghemrawi, Mostafa Khair (2020)
Endoplasmic Reticulum Stress and Unfolded Protein Response in Neurodegenerative DiseasesInternational Journal of Molecular Sciences, 21
(2012)
HIV-1 gp120 and drugs of abuse: Interac
Tomohiro Nakamura, S. Lipton (2010)
Preventing Ca2+-mediated nitrosative stress in neurodegenerative diseases: possible pharmacological strategies.Cell calcium, 47 2
J. Robinson-Papp, G. Gensler, A. Navis, S. Sherman, R. Ellis, B. Gelman, D. Kolson, S. Letendre, E. Singer, Miguel Valdes-Sueiras, S. Morgello (2019)
Characteristics of motor dysfunction in longstanding HIV.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
(2019)
HIV gp120-induced
M. Shimazawa, H. Hara (2006)
Inhibitor of double stranded RNA-dependent protein kinase protects against cell damage induced by ER stressNeuroscience Letters, 409
C. Vorhees, M. Williams (2006)
Morris water maze: procedures for assessing spatial and related forms of learning and memoryNature Protocols, 1
Young‐Jung Lee, I. Yeo, D. Choi, J. Yun, D. Son, S. Han, J. Hong (2021)
Amyloidogenic, neuroinflammatory and memory dysfunction effects of HIV-1 gp120Archives of Pharmacal Research, 44
E. Landucci, R. Lattanzi, E. Gerace, T. Scartabelli, G. Balboni, L. Negri, D. Pellegrini-Giampietro (2016)
Prokineticins are neuroprotective in models of cerebral ischemia and ischemic tolerance in vitroNeuropharmacology, 108
S. Tsalamandris, G. Vogiatzi, A. Antonopoulos, D. Tousoulis (2018)
The Role of Oxidative Stress
S. Álvarez, F. Brañas, M. Sánchez-Conde, S. Moreno, J. Quirós, M. Muñoz-Fernández (2020)
Frailty, markers of immune activation and oxidative stress in HIV infected elderlyPLoS ONE, 15
(2012)
HIV - 1 gp 120 and drugs of abuse : Interactions in the central nervous system
M. Alirezaei, D. Watry, C. Flynn, W. Kiosses, E. Masliah, B. Williams, M. Kaul, S. Lipton, H. Fox (2007)
Human Immunodeficiency Virus-1/Surface Glycoprotein 120 Induces Apoptosis through RNA-Activated Protein Kinase Signaling in NeuronsThe Journal of Neuroscience, 27
Shelly Lu (2013)
Glutathione synthesis.Biochimica et biophysica acta, 1830 5
J. Robinson‐Papp, G. Gensler, A. Navis, S. Sherman, R. J. Ellis, B. B. Gelman, D. L. Kolson, S. L. Letendre, E. J. Singer, M. Valdes‐Sueiras, S. Morgello (2020)
Characteristics of motor dysfunction in longstanding human immunodeficiency virus, 71
Jiang-yi Long, Jian-Min Chen, Yuan-jun Liao, Yi-jun Zhou, Bing-yu Liang, Yan Zhou (2020)
Naringin provides neuroprotection in CCL2-induced cognition impairment by attenuating neuronal apoptosis in the hippocampusBehavioral and Brain Functions : BBF, 16
Seon-Yong Jeong, D. Seol (2008)
The role of mitochondria in apoptosis.BMB reports, 41 1
R. Chang, Ka‐Chun Suen, Chi Ma, W. Elyaman, H. Ng, J. Hugon (2002)
Involvement of double‐stranded RNA‐dependent protein kinase and phosphorylation of eukaryotic initiation factor‐2α in neuronal degenerationJournal of Neurochemistry, 83
Yi-jun Zhou, Jian-Min Chen, K. Sapkota, Jiang-yi Long, Yuan-jun Liao, Junjun Jiang, Bing-yu Liang, Jinbin Wei, Yan Zhou (2020)
Pananx notoginseng saponins attenuate CCL2-induced cognitive deficits in rats via anti-inflammation and anti-apoptosis effects that involve suppressing over-activation of NMDA receptors.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 127
T. Price, N. Ercal, R. Nakaoke, W. Banks (2005)
HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cellsBrain Research, 1045
Y. Kiraz, Aysun Adan, Melis Yandim, Y. Baran (2016)
Major apoptotic mechanisms and genes involved in apoptosisTumor Biology, 37
Patrik Poprac, K. Jomová, Miriama Šimunková, V. Kollár, C. Rhodes, M. Valko (2017)
Targeting Free Radicals in Oxidative Stress-Related Human Diseases.Trends in pharmacological sciences, 38 7
Pavel Balderas (2018)
Flux-Independent NMDAR Signaling: Molecular Mediators, Cellular Functions, and ComplexitiesInternational Journal of Molecular Sciences, 19
S. Burugu, A. Daher, E. Meurs, A. Gatignol (2014)
HIV-1 translation and its regulation by cellular factors PKR and PACT.Virus research, 193
M. Corasaniti, M. Strongoli, S. Piccirilli, Robert Nisticò, Alfredo Costa, A. Bilotta, P. Turano, Alessandro Finazzi-Agrò, Giacinto Bagetta, Giacinto Bagetta (2000)
Apoptosis induced by gp120 in the neocortex of rat involves enhanced expression of cyclooxygenase type 2 and is prevented by NMDA receptor antagonists and by the 21-aminosteroid U-74389G.Biochemical and biophysical research communications, 274 3
Aida Flores, Ernesto Quesada (2013)
Entry inhibitors directed towards glycoprotein gp120: an overview on a promising target for HIV-1 therapy.Current medicinal chemistry, 20 6
Luyan Guo, Yan-yan Xing, Rui Pan, Mingliang Jiang, Zheng Gong, Liqing Lin, Junbin Wang, Guoyin Xiong, Jun Dong (2013)
Curcumin Protects Microglia and Primary Rat Cortical Neurons against HIV-1 gp120-Mediated Inflammation and ApoptosisPLoS ONE, 8
Rui Wang, P. Reddy (2017)
Role of Glutamate and NMDA Receptors in Alzheimer's Disease.Journal of Alzheimer's disease : JAD, 57 4
Akhil Katuri, J. Bryant, A. Heredia, T. Makar (2019)
Role of the inflammasomes in HIV-associated neuroinflammation and neurocognitive disorders.Experimental and molecular pathology, 108
D. Douek, J. Brenchley, M. Betts, D. Ambrozak, Brenna Hill, Y. Okamoto, J. Casazza, J. Kuruppu, K. Kunstman, Steven Wolinsky, Z. Grossman, M. Dybul, A. Oxenius, D. Price, M. Connors, R. Koup (2002)
HIV preferentially infects HIV-specific CD4+ T cellsNature, 417
(2019)
HIV gp 120 - induced neuroinflammation potentiates NMDA receptors to overcome basal suppression of inhibitory synapses by p 38 MAPK
C. Watkins, G. Treisman (2015)
Cognitive impairment in patients with AIDS – prevalence and severityHIV/AIDS (Auckland, N.Z.), 7
Thevani Pillay, Parveen Sobia, A. Olivier, K. Narain, Lenine Liebenberg, S. Ngcapu, Mesuli Mhlongo, Jo-Ann Passmore, C. Baxter, D. Archary (2019)
Semen IgM, IgG1, and IgG3 Differentially Associate With Pro-Inflammatory Cytokines in HIV-Infected MenFrontiers in Immunology, 9
Yan Zhou, Jianuo Liu, H. Xiong (2016)
HIV-1 Glycoprotein 120 Enhancement of N-Methyl-D-Aspartate NMDA Receptor-Mediated Excitatory Postsynaptic Currents: Implications for HIV-1-Associated Neural InjuryJournal of Neuroimmune Pharmacology, 12
It is widely accepted that the surface glycoprotein (gp120) of human immunodeficiency virus‐1 (HIV‐1) plays an important role in HIV‐1‐induced nerve damage and pathogenesis of HIV‐associated neurocognitive disorders (HAND). Our previous work has demonstrated that gp120 enhanced excitatory postsynaptic currents (EPSCs) mediated by N‐methyl‐d‐aspartate receptors (NMDARs) and caused neural injury. However, the relationship between gp120, NMDARs and HAND is still unclear. Several lines of evidence indicate that double‐stranded RNA‐activated protein kinase (PKR) is involved in NMDA‐induced cerebral ischaemia and retinal damage, but because its role in neuropathology is still debated, we examined whether PKR links oxidative stress and endoplasmic reticulum (ER) stress to exert a deleterious role in the rat model with gp120‐induced dementia. In this study, we found that NMDAR antagonist memantine or PKR inhibitor C16 improved gp120‐induced learning and memory impairment and inhibited gp120‐induced PKR activity. Furthermore, memantine or C16 was found to attenuate gp120‐induced neuroinflammation, oxidative stress, ER stress and its downstream IRE1α/JNK pathway. Additionally, memantine or C16 evidently inhibited apoptotic pathways by reducing the Bax and caspase‐3, ‐8, ‐9 expressions and increasing Bcl‐2 expression. So the NMDA receptor antagonists could alleviate HIV/gp120‐induced dementia in the rat model by altering PKR level. In conclusion, this study demonstrates that NMDARs play a key role in HIV/gp120‐induced hippocampal damage and cognitive dysfunction through PKR‐mediated oxidative stress, ER stress, and IRE1α/JNK signalling pathway in rats, and implicating PKR inhibitors could provide a novel neuroprotective strategy for HAND via inhibiting ER stress and its downstream IRE1α signalling pathway.
European Journal of Neuroscience – Wiley
Published: Jul 1, 2022
Keywords: double‐stranded RNA‐dependent protein kinase; endoplasmic reticulum (ER) stress; HIV‐1 envelope glycoprotein 120; HIV‐associated neurocognitive disorder; N ‐methyl‐ d ‐aspartate receptor
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.