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Ni‐Catalyzed Regioselective Cyclotrimerization of Internal Esteryl Alkynes towards Polysubstituted Benzene Rings

Ni‐Catalyzed Regioselective Cyclotrimerization of Internal Esteryl Alkynes towards... Transition‐metal‐catalyzed [2+2+2] cycloaddition of alkynes is a core synthetic approach to benzene rings. Herein we describe an efficient system based on inexpensive nickel catalyst and phosphine ligand that facilitate cyclotrimerization of various internal esteryl alkynes. The regioselectivity of the protocol was precisely controlled, and a series of polysubstituted benzene rings mainly composed of 1,2,4‐isomers were provided. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Helvetica Chimica Acta Wiley

Ni‐Catalyzed Regioselective Cyclotrimerization of Internal Esteryl Alkynes towards Polysubstituted Benzene Rings

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References (87)

Publisher
Wiley
Copyright
© 2022 Wiley‐VHCA AG, Zurich, Switzerland
ISSN
0018-019X
eISSN
1522-2675
DOI
10.1002/hlca.202200005
Publisher site
See Article on Publisher Site

Abstract

Transition‐metal‐catalyzed [2+2+2] cycloaddition of alkynes is a core synthetic approach to benzene rings. Herein we describe an efficient system based on inexpensive nickel catalyst and phosphine ligand that facilitate cyclotrimerization of various internal esteryl alkynes. The regioselectivity of the protocol was precisely controlled, and a series of polysubstituted benzene rings mainly composed of 1,2,4‐isomers were provided.

Journal

Helvetica Chimica ActaWiley

Published: May 1, 2022

Keywords: C−C bond formation; cycloaddition; internal esteryl alkynes; nickel; catalysis; regional selectivity

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