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MOLECULAR PROFILING TO PREDICT SURVIVAL FOR COLON CANCER DEVELOPED IN THE NETHERLANDS Researchers in Leiden University Medical Centre, department of endocrine, gastrointestinal and oncologic surgery, and the Netherlands Cancer Institute have been working collaboratively to develop a method of accurately predicting which patients with colon cancer are more likely to have their disease recur following surgery and who would, therefore, be more likely to benefit from adjuvant chemotherapy. The two centres concentrated their efforts in analysing different expressions of genes in the entire genome of tumour tissues from 121 patients with stage II colon cancer. These patients had not received chemotherapy following surgery to remove the tumour. This exercise managed to identify two distinct groups of patients, both groups having distinct clinical outcomes. European patients with stage II colon cancer are statistically predicted to have an overall 5‐year survival of about 80%. This study confirmed this with the patients in the so‐called ‘good outcome’ group being 90% and of the patients expected to have a ‘poor outcome’ only 40% survived for 5 years post diagnosis. At the present time, no randomized controlled clinical trials had managed to prove the advantage of giving adjuvant chemotherapy to stage II colon
European Journal of Cancer Care – Wiley
Published: May 1, 2008
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