Access the full text.
Sign up today, get DeepDyve free for 14 days.
V. Rienzo, M. Minelli, A. Musarra, R. Sambugaro, S. Pecora, W. Canonica, G. Passalacqua (2005)
Post‐marketing survey on the safety of sublingual immunotherapy in children below the age of 5 yearsClinical & Experimental Allergy, 35
T. Larsen, Lars Poulsen, M. Mélac, A. Combebias, C. André, H. Malling (2006)
Safety and tolerability of grass pollen tablets in sublingual immunotherapy – a phase‐1 studyAllergy, 61
J. Allam, B. Niederhagen, M. Bucheler, T. Appel, H. Betten, T. Bieber, S. Bergé, N. Novak (2006)
Comparative analysis of nasal and oral mucosa dendritic cellsAllergy, 61
L. Blazowski (2007)
ALLERGY Net: Anaphylactic shock because of sublingual immunotherapy overdose during third year of maintenance doseAllergy, 63
(2008)
New visions in specific immunotherapy in children : an iPAC summary and future trends
F. Ippoliti, W. Santis, A. Volterrani, L. Lenti, N. Canitano, S. Lucarelli, T. Frediani (2003)
Immunomodulation during sublingual therapy in allergic childrenPediatric Allergy and Immunology, 14
E. Álvarez-Cuesta, J. Bousquet, G. Canonica, S. Durham, H. Malling, E. Valovirta (2006)
Standards for practical allergen‐specific immunotherapyAllergy, 61
Rolinck-Werninghaus C, Wolf Liebke, J. Skripak, R. Wood, Gidaro Gb, M. F, Sensi L, I. C, Frati F, C. G. (2006)
The Upper Airway A Prospective , Randomized , Double-blind , Placebo-Controlled Multi-centre Study on the Efficacy and Safety of Sublingual Immunotherapy ( SLIT ) in Children With Seasonal Allergic Rhinoconjunctivitis to Grass Pollen
S. Radulovic, M. Calderón, Duncan Wilson, S. Durham (2010)
Sublingual immunotherapy for allergic rhinitisCochrane Database of Systematic Reviews
E. Röder, M. Berger, W. Hop, R. Bernsen, H. Groot, R. Wijk (2007)
Sublingual immunotherapy with grass pollen is not effective in symptomatic youngsters in primary care.The Journal of allergy and clinical immunology, 119 4
G. Canonica, C. Baena-Cagnani, J. Bousquet, P. Bousquet, R. Lockey, H. Malling, G. Passalacqua, P. Potter, E. Valovirta (2007)
Recommendations for standardization of clinical trials with Allergen Specific Immunotherapy for respiratory allergy. A statement of a World Allergy Organization (WAO) taskforceAllergy, 62
H. Mosbech, O. ØTerballe (1988)
Does the effect of immunotherapy last after termination of treatment?Allergy, 43
R. Grembiale, L. Camporota, S. Naty, C. Tranfa, R. Djukanović, S. Marsico (2000)
Effects of specific immunotherapy in allergic rhinitic individuals with bronchial hyperresponsiveness.American journal of respiratory and critical care medicine, 162 6
A. Roches, L. Paradis, J. Knani, A. Hejjaoui, H. Dhivert, P. Chanez, J. Bousquet (1996)
Immunotherapy with a standardized Dermatophagoides pteronyssinus extract. V. Duration of the efficacy of immunotherapy after its cessation.Allergy, 51 6
M. Marogna, Igino Spadolini, Alessandro Massolo, G. Canonica, G. Passalacqua (2004)
Randomized controlled open study of sublingual immunotherapy for respiratory allergy in real‐life: clinical efficacy and moreAllergy, 59
S. Walker, V. Varney, M. Gaga, M. Jacobson, S. Durham (1995)
Grass pollen immunotherapy: efficacy and safety during a 4‐year follow‐up studyAllergy, 50
G. Passalacqua, S. Durham (2007)
Allergic rhinitis and its impact on asthma update: allergen immunotherapy.The Journal of allergy and clinical immunology, 119 4
B. Niggemann, L. Jacobsen, S. Dreborg, H. Ferdousi, S. Halken, A. Høst, A. Koivikko, D. Koller, L. Norberg, R. Urbanek, E. Valovirta, U. Wahn, C. Möller (2006)
Five‐year follow‐up on the PAT study: specific immunotherapy and long‐term prevention of asthma in childrenAllergy, 61
L. Jacobsen, B. Niggemann, S. Dreborg, H. Ferdousi, S. Halken, A. Høst, A. Koivikko, L. Norberg, E. Valovirta, U. Wahn, C. Möller (2007)
Specific immunotherapy has long‐term preventive effect of seasonal and perennial asthma: 10‐year follow‐up on the PAT studyAllergy, 62
F. Purello-D’Ambrosio, S. Gangemi, R. Merendino, S. Isola, P. Puccinelli, S. Parmiani, L. Ricciardi (2001)
Prevention of new sensitizations in monosensitized subjects submitted to specific immunotherapy or not. A retrospective studyClinical & Experimental Allergy, 31
Gruber, Eber, Mileder, Modl, Weinhandl, Zach (1999)
Effect of specific immunotherapy with house dust mite extract on the bronchial responsiveness of paediatric asthma patientsClinical & Experimental Allergy, 29
G. Pajno, L. Morabito, G. Barberio, S. Parmiani (2000)
Clinical and immunologic effects of long‐term sublingual immunotherapy in asthmatic children sensitized to mites:a double‐blind, placebo‐controlled studyAllergy, 55
Z. Calamita, H. Saconato, Andrea Pelá, Á. Atallah (2006)
Efficacy of sublingual immunotherapy in asthma: systematic review of randomized‐clinical trials using the Cochrane Collaboration methodAllergy, 61
A. Fiocchi, G. Pajno, S. Grutta, F. Pezzuto, C. Incorvaia, L. Sensi, F. Marcucci, F. Frati (2005)
Safety of sublingual-swallow immunotherapy in children aged 3 to 7 years.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 95 3
Christophe Delacourt, M. Benoist, S. Waernessyckle, P. Rufin, J. Brouard, Jacques DE BLIC, Pierre Scheinmann (2001)
Relationship between bronchial responsiveness and clinical evolution in infants who wheeze: a four-year prospective study.American journal of respiratory and critical care medicine, 164 8 Pt 1
R. Ross, H. Nelson, I. Finegold (2000)
Effectiveness of specific immunotherapy in the treatment of hymenoptera venom hypersensitivity: a meta-analysis.Clinical therapeutics, 22 3
C. Möller, S. Dreborg, H. Ferdousi, S. Halken, A. Høst, L. Jacobsen, A. Koivikko, D. Koller, B. Niggemann, L. Norberg, R. Urbanek, E. Valovirta, U. Wahn (2002)
Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study).The Journal of allergy and clinical immunology, 109 2
M. Rottem (2010)
[Allergic rhinitis and its impact on asthma].Harefuah, 149 6
Michael Abramson, R. Puy, J. Weiner (1999)
Immunotherapy in asthma: an updated systematic reviewAllergy, 54
A. Bufe, E. Ziegler-Kirbach, E. Stoeckmann, P. Heidemann, K. Gehlhar, T. Holland-Letz, W. Braun (2004)
Efficacy of sublingual swallow immunotherapy in children with severe grass pollen allergic symptoms: a double‐blind placebo‐controlled studyAllergy, 59
M. Khinchi, L. Poulsen, F. Carat, C. André, A. Hansen, H. Malling (2004)
Clinical efficacy of sublingual and subcutaneous birch pollen allergen‐specific immunotherapy: a randomized, placebo‐controlled, double‐blind, double‐dummy studyAllergy, 59
F. Bonifazi, M. Jutel, Biló Bm, J. Birnbaum, U. Müller (2005)
Prevention and treatment of hymenoptera venom allergy: guidelines for clinical practiceAllergy, 60
C. Ebner, U. Siemann, Barbara Bohle, Martin Willheim, Ursula Wiedermann, S. Schenk, F. Klotz, H. Ebner, D. Kraft, Otto Scheiner (1997)
Immunological changes during specific immunotherapy of grass pollen allergy: reduced lymphoproliferative responses to allergen and shift from TH2 to TH1 in T‐cell clones specific for Phi p 1, a major grass pollen allergenClinical & Experimental Allergy, 27
H. Mosbech (2004)
Anaphylaxis to insect venom.Novartis Foundation symposium, 257
A. Frew, R. Powell, C. Corrigan, S. Durham (2006)
Efficacy and safety of specific immunotherapy with SQ allergen extract in treatment-resistant seasonal allergic rhinoconjunctivitis.The Journal of allergy and clinical immunology, 117 2
Sabina Rak, Olle Löwhagen, Per Venge (1988)
The effect of immunotherapy on bronchial hyperresponsiveness and eosinophil cationic protein in pollen-allergic patients.The Journal of allergy and clinical immunology, 82 3 Pt 1
C. Niu, Wu-Yuan Chen, Jingwen Huang, K. Lue, Jiu-Yao Wang (2006)
Efficacy of sublingual immunotherapy with high-dose mite extracts in asthma: a multi-center, double-blind, randomized, and placebo-controlled study in Taiwan.Respiratory medicine, 100 8
A. Antico, M. Pagani, A. Crema (2006)
Anaphylaxis by latex sublingual immunotherapyAllergy, 61
M. Calderón, B. Alves, M. Jacobson, B. Hurwitz, Aziz Sheikh, S. Durham (2007)
Allergen injection immunotherapy for seasonal allergic rhinitis.The Cochrane database of systematic reviews, 1
K. Nouri-Aria, P. Wachholz, J. Francis, M. Jacobson, S. Walker, L. Wilcock, Steven Staple, R. Aalberse, S. Till, S. Durham (2004)
Grass Pollen Immunotherapy Induces Mucosal and Peripheral IL-10 Responses and Blocking IgG Activity1The Journal of Immunology, 172
Wilson (2003)
Sublingual immunotherapy for allergic rhinitisCochrane Database Syst Rev, 2
S. Durham, William Yang, M. Pedersen, N. Johansen, S. Rak (2006)
Sublingual immunotherapy with once-daily grass allergen tablets: a randomized controlled trial in seasonal allergic rhinoconjunctivitis.The Journal of allergy and clinical immunology, 117 4
Y. Koh, Chang Kim (2003)
The development of asthma in patients with allergic rhinitisCurrent Opinion in Allergy and Clinical Immunology, 3
M. Abramson, R. Puy, J. Weiner (2003)
Allergen immunotherapy for asthma.The Cochrane database of systematic reviews, 4
A. Didier, H. Malling, M. Worm, F. Horak, S. Jäger, A. Montagut, C. André, O. Beaumont, M. Mélac (2007)
Optimal dose, efficacy, and safety of once-daily sublingual immunotherapy with a 5-grass pollen tablet for seasonal allergic rhinitis.The Journal of allergy and clinical immunology, 120 6
R. Dahl, A. Kapp, G. Colombo, J. Monchy, S. Rak, W. Emminger, M. Rivas, M. Ribel, S. Durham (2006)
Efficacy and safety of sublingual immunotherapy with grass allergen tablets for seasonal allergic rhinoconjunctivitis.The Journal of allergy and clinical immunology, 118 2
V. Rienzo, F. Marcucci, P. Puccinelli, S. Parmiani, F. Frati, L. Sensi, G. Canonica, G. Passalacqua (2003)
Long‐lasting effect of sublingual immunotherapy in children with asthma due to house dust mite: a 10‐year prospective studyClinical & Experimental Allergy, 33
U. Müller, D. Golden, P. Demarco, R. Lockey (2004)
Immunotherapy for hymenoptera venom and biting insect hypersensitivity.Clinical allergy and immunology, 18
A. Roches, L. Paradis, Menardo Jl, S. Bouges, J. Daurès, J. Bousquet (1997)
Immunotherapy with a standardized Dermatophagoides pteronyssinus extract. VI. Specific immunotherapy prevents the onset of new sensitizations in children.The Journal of allergy and clinical immunology, 99 4
P. Eng, M. Borer-Reinhold, I. Heijnen, H. Gnehm (2006)
Twelve‐year follow‐up after discontinuation of preseasonal grass pollen immunotherapy in childhoodAllergy, 61
G. Hedlin, H. Heilborn, G. Lilja, K. Norrlind, K. Pegelow, C. Schou, H. Løwenstein (1995)
Long-term follow-up of patients treated with a three-year course of cat or dog immunotherapy.The Journal of allergy and clinical immunology, 96 6 Pt 1
M. Rosa, Carmen Ranno, C. André, F. Carat, M. Tosca, G. Canonica (1999)
Double-blind placebo-controlled evaluation of sublingual-swallow immunotherapy with standardized Parietaria judaica extract in children with allergic rhinoconjunctivitis.The Journal of allergy and clinical immunology, 104 2 Pt 1
J. Bousquet, R. Lockey, H. Malling, E. Álvarez-Cuesta, G. Canonica, M. Chapman, P. Creticos, J. Dayer, S. Durham, P. Demoly, R. Goldstein, T. Ishikawa, K. Ito, D. Kraft, P. Lambert, H. Løwenstein, U. Müller, P. Norman, R. Reisman, R. Valenta, E. Valovirta, H. Yssel (1998)
Allergen immunotherapy: therapeutic vaccines for allergic diseasesAllergy, 53
S. Durham, S. Walker, E. Varga, M. Jacobson, F. O’Brien, W. Noble, S. Till, Q. Hamid, K. Nouri-Aria (1999)
Long-term clinical efficacy of grass-pollen immunotherapy.The New England journal of medicine, 341 7
Teri Jordan, Stacie Jones, Little Rock, Valovirta E, Jacobsen L, Ljørring C, Koivikko A, Savolainen J, Kirsi Jarvinen, S. Sicherer, N. York (2006)
Clinical efficacy and safety of sublingual immunotherapy with tree pollen extract in childrenAllergy, 61
K. Drachenberg, A. Wheeler, P. Stuebner, F. Horak (2001)
A well‐tolerated grass pollen‐specific allergy vaccine containing a novel adjuvant, monophosphoryl lipid A, reduces allergic symptoms after only four preseasonal injectionsAllergy, 56
Duncan Wilson, K. Nouri-Aria, S. Walker, G. Pajno, F. O’Brien, M. Jacobson, I. Mackay, S Durham (2001)
Grass pollen immunotherapy: symptomatic improvement correlates with reductions in eosinophils and IL-5 mRNA expression in the nasal mucosa during the pollen season.The Journal of allergy and clinical immunology, 107 6
H. Malling (1998)
Immunotherapy as an effective tool in allergy treatment.Allergy, 53 5
J. Olaguibel, M. Puebla (2005)
Efficacy of sublingual allergen vaccination for respiratory allergy in children. Conclusions from one meta-analysis.Journal of investigational allergology & clinical immunology, 15 1
(1987)
Immunotherapy with Hymenoptera venoms. Position paper of the Working Group on Immunotherapy of the European Academy of Allergy and Clinical Immunology
J. Kleine‐Tebbe, M. Ribel, D. Herold (2006)
Safety of a SQ‐standardised grass allergen tablet for sublingual immunotherapy: a randomized, placebo‐controlled trialAllergy, 61
L. Cox, D. Linnemann, H. Nolte, D. Weldon, I. Finegold, H. Nelson (2006)
Sublingual immunotherapy: a comprehensive review.The Journal of allergy and clinical immunology, 117 5
M. Penagos, G. Passalacqua, E. Compalati, C. Baena-Cagnani, S. Orozco, A. Pedroza, G. Canonica (2008)
Metaanalysis of the efficacy of sublingual immunotherapy in the treatment of allergic asthma in pediatric patients, 3 to 18 years of age.Chest, 133 3
C. André, R. Fadel (2007)
Anaphylaxis caused by allergen sublingual immunotherapy?Allergy, 62
G. Hedlin, S. Wille, L. Browaldh, H. Hildebrand, D. Holmgren, A. Lindfors, S. Nordvall, H. Lowenstein (1999)
Immunotherapy in children with allergic asthma: effect on bronchial hyperreactivity and pharmacotherapy.The Journal of allergy and clinical immunology, 103 4
R. Rossi, Giorgio Monasterolo, G. Coco, L. Silvestro, D. Operti (2007)
Evaluation of serum IgG4 antibodies specific to grass pollen allergen components in the follow up of allergic patients undergoing subcutaneous and sublingual immunotherapy.Vaccine, 25 5
L. Toorn, S. Overbeek, J. Prins, H. Hoogsteden, J. Jongste (2003)
Asthma remission: does it exist?Current opinion in pulmonary medicine, 9 1
E. Novembre, E. Galli, F. Landi, C. Caffarelli, M. Pifferi, E. Marco, S. Burastero, G. Calori, L. Benetti, P. Bonazza, P. Puccinelli, S. Parmiani, R. Bernardini, A. Vierucci (2004)
Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis.The Journal of allergy and clinical immunology, 114 4
M. Penagos, E. Compalati, F. Tarantini, R. Baena-Cagnani, J. Huerta, G. Passalacqua, G. Canonica (2006)
Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 97 2
Robert Ross, Harold Nelson, Ira Finegold (2000)
Effectiveness of specific immunotherapy in the treatment of allergic rhinitis: an analysis of randomized, prospective, single- or double-blind, placebo-controlled studies.Clinical therapeutics, 22 3
H. Malling (2002)
Is sublingual immunotherapy clinically effective?Current Opinion in Allergy and Clinical Immunology, 2
P. Eng, M. Reinhold, H. Gnehm (2002)
Long‐term efficacy of preseasonal grass pollen immunotherapy in childrenAllergy, 57
N. Pham‐Thi, J. Blic, P. Scheinmann (2006)
Sublingual immunotherapy in the treatment of childrenAllergy, 61
L. Jacobsen, B. Petersen, J. Wihl, H. Løwenstein, H. Ipsen (1997)
Immunotherapy with partially purified and standardized tree pollen extracts. IV. Results from long‐term (6‐year) follow‐upAllergy, 52
T. Casale, W. Busse, J. Kline, Z. Ballas, M. Moss, R. Townley, M. Mokhtarani, V. Seyfert-Margolis, A. Asare, K. Bateman, Y. Deniz (2006)
Omalizumab pretreatment decreases acute reactions after rush immunotherapy for ragweed-induced seasonal allergic rhinitis.The Journal of allergy and clinical immunology, 117 1
Robert Ross, Harold Nelson, Ira Finegold (2000)
Effectiveness of specific immunotherapy in the treatment of asthma: a meta-analysis of prospective, randomized, double-blind, placebo-controlled studies.Clinical therapeutics, 22 3
G. Pajno, G. Barberio, F. Luca, L. Morabito, S. Parmiani (2001)
Prevention of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy. A six‐year follow‐up study.Clinical & Experimental Allergy, 31
Abramson (1995)
Is allergen immunotherapy effective in asthma?Am J Respir Crit Med, 151
C. Rolinck‐Werninghaus, E. Hamelmann, T. Keil, M. Kulig, K. Koetz, B. Gerstner, J. Kuehr, S. Zielen, U. Schauer, W. Kamin, A. Berg, J. Hammermann, B. Weinkauf, G. Weidinger, S. Stenglein, U. Wahn (2004)
The co‐seasonal application of anti‐IgE after preseasonal specific immunotherapy decreases ocular and nasal symptom scores and rescue medication use in grass pollen allergic childrenAllergy, 59
J. Bousquet, R. Lockey, H. Malling, E. Álvarez-Cuesta, G. Canonica, M. Chapman, P. Creticos, J. Dayer, S. Durham, P. Demoly, R. Goldstein, T. Ishikawa, K. Ito, D. Kraft, P. Lambert, H. Løwenstein, U. Müller, P. Norman, R. Reisman, R. Valenta, E. Valovirta, H. Yssel (1998)
Allergen immunotherapy: therapeutic vaccines for allergic diseases. World Health Organization. American academy of Allergy, Asthma and Immunology.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 81 5
J. Savolainen, K. Nieminen, K. Laaksonen, T. Laiho, L. Jacobsen, R. Lahesmaa, Erkki Terho, E. Valovirta (2007)
Allergen‐induced in vitro expression of IL‐18, SLAM and GATA‐3 mRNA in PBMC during sublingual immunotherapyAllergy, 62
Christopher Corrigan, J. Kettner, C. Doemer, O. Cromwell, A. Narkus (2005)
Efficacy and safety of preseasonal‐specific immunotherapy with an aluminium‐adsorbed six‐grass pollen allergoidAllergy, 60
A. Eifan, S. Keleş, N. Bahceciler, I. Barlan (2007)
Anaphylaxis to multiple pollen allergen sublingual immunotherapyAllergy, 62
HJ Malling, L. Lund, H. Ipsen, L. Poulsen (2006)
Safety and immunological changes during sublingual immunotherapy with standardized quality grass allergen tablets.Journal of investigational allergology & clinical immunology, 16 3
G. Pajno, D. Vita, S. Parmiani, L. Caminiti, S. Grutta, G. Barberio (2003)
Impact of sublingual immunotherapy on seasonal asthma and skin reactivity in children allergic to Parietaria pollen treated with inhaled fluticasone propionateClinical & Experimental Allergy, 33
P. Wachholz, K. Nouri-Aria, Duncan Wilson, S. Walker, A. Verhoef, S. Till, S. Durham (2002)
Grass pollen immunotherapy for hayfever is associated with increases in local nasal but not peripheral Th1 : Th2 cytokine ratiosImmunology, 105
Q. Hamid, E. Schotman, M. Jacobson, S. Walker, S Durham (1997)
Increases in IL-12 messenger RNA+ cells accompany inhibition of allergen-induced late skin responses after successful grass pollen immunotherapy.The Journal of allergy and clinical immunology, 99 2
A welltolerated grass pollenspecific
Specific immunotherapy is indicated for confirmed immunoglobulin E‐mediated airway diseases using standardized allergen products with documented clinical efficacy and safety. For decades the subcutaneous route of administration (SCIT) has been the gold standard. Recently, the sublingual immunotherapy (SLIT) has also been investigated in children. SCIT, especially with grass and birch pollens but also house dust mites, is an effective treatment in children with allergic rhinitis and asthma when a significant part of their symptoms are caused by these allergens. A long‐term effect up to 12 yr after discontinuation of SCIT with timothy allergen has been shown. Efficacy and safety of SLIT in pollen allergic rhinoconjunctivitis have been demonstrated in adults. The evidence in children is a little less convincing, and more data is needed. The clinical relevance, long‐term results and the size of the effect, as well as the dose, the treatment regimen and duration has not been sufficiently elaborated. It is demonstrated that SCIT has the potential for preventing the development of asthma in children with allergic rhinoconjunctivitis. Also one randomized study indicates a preventive effect of SLIT in children on the development of asthma. At present, there are no studies who clearly demonstrates either a long‐term effect or a preventive effect on the development of asthma of SLIT in children. The areas with lack of evidence should be addressed in well performed prospective, randomized long‐term studies both with SCIT and SLIT. This review was initiated by iPAC (international Pediatric Allergy and Asthma Consortium) and aims to review current knowledge related to specific immunotherapy in childhood, and to identify needs for future research in this field.
Pediatric Allergy and Immunology – Wiley
Published: Aug 1, 2008
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.