Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Neonatal hyperbilirubinemia and childhood allergic diseases: a systematic review

Neonatal hyperbilirubinemia and childhood allergic diseases: a systematic review Studies have found a link between neonatal hyperbilirubinemia (NNH) and/or neonatal phototherapy (NPT) and childhood allergic diseases. The present systematic review was conducted to provide updated evidence and to provide direction regarding future research. A systematic search of the published literature was carried out. Observational studies including children up to 12 yr of age were included. Data extraction was carried out using a standardized data extraction form that was designed and pilot tested a priori. The analysis was carried out with the statistical software RevMan (version 5.2) (Protocol is registered at PROSPERO: CRD42014009943). Of 79 citations retrieved, a total of 7 good quality studies (n = 101,499) were included in the final analysis. There was a significant increase in the odds of asthma and allergic rhinitis (AR) after NNH (asthma, OR 4.26 (95% CI 4.04–4.5); AR, OR 5.37 (95% CI 4.16–6.92)) and after NPT (asthma, OR 3.81 (95% CI 3.53–4.11); AR, OR 3.04(95% CI 2.13–4.32)). A similar increase in the trend was noted for late onset of asthma after NNH (OR 4.1 (95% CI 2.82–5.94)), and hospitalization due to asthma after NPT (OR 3.56 (95% CI 2.93–4.33)). The GRADE evidence generated was of ‘low quality’. The current evidence finds a significant increase in the odds of childhood allergic diseases after NNH and/or NPT. As observational studies were included, the evidence generated was of ‘low quality’. Future studies should try to elucidate the pathophysiologic link between NNH and/or NPT and childhood allergic diseases. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Neonatal hyperbilirubinemia and childhood allergic diseases: a systematic review

Download PDF
10 pages

Loading next page...
 
/lp/wiley/neonatal-hyperbilirubinemia-and-childhood-allergic-diseases-a-dG9SoXkCtO

References (29)

Publisher
Wiley
Copyright
Copyright © 2015 John Wiley & Sons A/S.
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/pai.12281
pmid
25229699
Publisher site
See Article on Publisher Site

Abstract

Studies have found a link between neonatal hyperbilirubinemia (NNH) and/or neonatal phototherapy (NPT) and childhood allergic diseases. The present systematic review was conducted to provide updated evidence and to provide direction regarding future research. A systematic search of the published literature was carried out. Observational studies including children up to 12 yr of age were included. Data extraction was carried out using a standardized data extraction form that was designed and pilot tested a priori. The analysis was carried out with the statistical software RevMan (version 5.2) (Protocol is registered at PROSPERO: CRD42014009943). Of 79 citations retrieved, a total of 7 good quality studies (n = 101,499) were included in the final analysis. There was a significant increase in the odds of asthma and allergic rhinitis (AR) after NNH (asthma, OR 4.26 (95% CI 4.04–4.5); AR, OR 5.37 (95% CI 4.16–6.92)) and after NPT (asthma, OR 3.81 (95% CI 3.53–4.11); AR, OR 3.04(95% CI 2.13–4.32)). A similar increase in the trend was noted for late onset of asthma after NNH (OR 4.1 (95% CI 2.82–5.94)), and hospitalization due to asthma after NPT (OR 3.56 (95% CI 2.93–4.33)). The GRADE evidence generated was of ‘low quality’. The current evidence finds a significant increase in the odds of childhood allergic diseases after NNH and/or NPT. As observational studies were included, the evidence generated was of ‘low quality’. Future studies should try to elucidate the pathophysiologic link between NNH and/or NPT and childhood allergic diseases.

Journal

Pediatric Allergy and Immunology – Wiley

Published: Feb 1, 2015

There are no references for this article.