Access the full text.
Sign up today, get DeepDyve free for 14 days.
V. Os, A. Konings, J. Down (1992)
Radiation dose as a factor in host preparation for bone marrow transplantation across different genetic barriers.International journal of radiation biology, 61 4
W. Huppes, B. Geus, C. Zurcher, D. Bekkum (1992)
Acute human vs. mouse graft vs. host disease in normal and immunodeficient miceEuropean Journal of Immunology, 22
C. Sentman, Vinay Kumar, M. Bennett (1991)
Rejection of bone marrow cell allografts by natural killer cell subsets: 5E6+ cell specificity for Hh‐1 determinant 2 shared by H‐2d and H‐2fEuropean Journal of Immunology, 21
S. Nonoyama, Franklin Smith, Hans Ochs (1993)
Specific antibody production to a recall or a neoantigen by SCID mice reconstituted with human peripheral blood lymphocytes.Journal of immunology, 151 7
B. Blazar, R. Hirsch, R. Gress, S. Carroll, D. Vallera (1991)
In vivo administration of anti-CD3 monoclonal antibodies or immunotoxins in murine recipients of allogeneic T cell-depleted marrow for the promotion of engraftment.Journal of immunology, 147 5
Y. Reisner, L. Itzicovitch, A. Meshorer, N. Sharon (1978)
Hemopoietic stem cell transplantation using mouse bone marrow and spleen cells fractionated by lectins.Proceedings of the National Academy of Sciences of the United States of America, 75 6
D. Mosier (1991)
Adoptive transfer of human lymphoid cells to severely immunodeficient mice: models for normal human immune function, autoimmunity, lymphomagenesis, and AIDS.Advances in immunology, 50
D. Mosier, R. Gulizia, P. MacIsaac, L. Corey, P. Greenberg (1993)
Resistance to human immunodeficiency virus 1 infection of SCID mice reconstituted with peripheral blood leukocytes from donors vaccinated with vaccinia gp160 and recombinant gp160.Proceedings of the National Academy of Sciences of the United States of America, 90
T. Lapidot, F. Pflumio, M. Doedens, B. Murdoch, Douglas Williams, J. Dick (1992)
Cytokine stimulation of multilineage hematopoiesis from immature human cells engrafted in SCID mice.Science, 255 5048
M. Ghetie, J. Richardson, T. Tucker, Diane Jones, J. Uhr, E. Vitetta (1990)
Disseminated or localized growth of a human B‐cell tumor (Daudi) in scid miceInternational Journal of Cancer, 45
D. Mosier, R. Gulizia, P. MacIsaac, B. Torbett, J. Levy (1993)
Rapid loss of CD4+ T cells in human-PBL-SCID mice by noncytopathic HIV isolates.Science, 260 5108
J. Platt, G. Vercellotti, A. Dalmasso, A. Dalmasso, A. Matas, R. Bolman, J. Najarian, F. Bach, F. Bach (1990)
Transplantation of discordant xenografts: a review of progress.Immunology today, 11 12
L. Lee, D. Sachs, M. Sykes (1993)
Effect of natural killer cell depletion on long-term multilineage allogeneic bone marrow engraftment.Transplantation proceedings, 25 1 Pt 2
A. Saxon, E. Macy, K. Denis, M. Tary‐Lehmann, O. Witte, J. Braun (1991)
Limited B cell repertoire in severe combined immunodeficient mice engrafted with peripheral blood mononuclear cells derived from immunodeficient or normal humans.The Journal of clinical investigation, 87 2
S. Williams, T. Umemoto, H. Kida, E. Repasky, R. Bankert (1992)
Engraftment of human peripheral blood leukocytes into severe combined immunodeficient mice results in the long term and dynamic production of human xenoreactive antibodies.Journal of immunology, 149 8
S. Kamel‐Reid, M. Letarte, C. Sirard, M. Doedens, T. Grunberger, G. Fulop, M. Freedman, R. Phillips, J. Dick (1989)
A model of human acute lymphoblastic leukemia in immune-deficient SCID mice.Science, 246 4937
G. Bosma, R. Custer, M. Bosma (1983)
A severe combined immunodeficiency mutation in the mouseNature, 301
M. Duchosal, S. Eming, P. McConahey, F. Dixon (1992)
Characterization of hu-PBL-SCID mice with high human immunoglobulin serum levels and graft-versus-host disease.The American journal of pathology, 141 5
P. Fressy (1992)
[Role of the ABO system in transplants and grafts].Revue francaise de transfusion et d'hemobiologie : bulletin de la Societe nationale de transfusion sanguine, 35 5
I. Aksentijevich, D. Sachs, M. Sykes (1992)
HUMORAL TOLERANCE IN XENOGENEIC BMT RECIPIENTS CONDITIONED BY A NONMYELOABLATIVE REGIMENTransplantation, 53
M. Duchosal, S. Eming, P. Fischer, D. Leturcq, C. Barbas, P. McConahey, R. Caothien, F. Dixon, D. Burton (1992)
Immunization of hu-PBL–SCID mice and the rescue of human monoclonal Fab fragments through combinatorial librariesNature, 355
J. Cabaniols, I. Bolonakis-Tsilivakos, R. Cibotti, E. Churaqui, H. Duc, O. Halle‐Pannenko, K. Kosmatopoulos (1991)
Mechanism of hybrid resistance. The role of a natural antibody in parental bone marrow cell rejection.Journal of immunology, 146 3
M. Charley, M. Tharp, J. Locker, J. Deng, J. Goslen, T. Mauro, P. McCoy, E. Abell, B. Jegasothy (1990)
Establishment of a human cutaneous T-cell lymphoma in C.B-17 SCID mice.The Journal of investigative dermatology, 94 3
W. Huppes, John Paulonis, H. Dijk, N. Rooijen, D. Bekkum (1993)
The role of natural antibodies and ABO (H) blood groups in transplantation of human lymphoid cells into miceEuropean Journal of Immunology, 23
S. Kamel-Reid, John Dick (1988)
Engraftment of immune-deficient mice with human hematopoietic stem cells.Science, 242 4886
Y. Yu, V. Kumar, M. Bennett (1992)
Murine natural killer cells and marrow graft rejection.Annual review of immunology, 10
W. Murphy, M. Bennett, M. Anver, M. Baseler, D. Longo (1992)
Human‐mouse lymphoid chimeras: host‐vs.‐graft and graft‐vs.‐host reactionsEuropean Journal of Immunology, 22
I. Lubin, H. Segall, H. Marcus, M. David, L. Kulova, M. Steinitz, Porat Eriich, J. Gan, Y. Reisner (1994)
Engraftment of human peripheral blood lymphocytes in normal strains of mice.Blood, 83 8
D. Mosier, R. Gulizia, S. Baird, D. Wilson, D. Spector, S. Spector (1991)
Human immunodeficiency virus infection of human-PBL-SCID mice.Science, 251 4995
G. Cudkowicz, M. Bennett (1971)
PECULIAR IMMUNOBIOLOGY OF BONE MARROW ALLOGRAFTSThe Journal of Experimental Medicine, 134
D. Mosier, R. Gulizia, P. MacIsaac, B. Mathieson, G. Smith, S. Hu, L. Corey, P. Greenberg (1992)
Evaluation of gp160 vaccinees in the hu-PBL-SCID mouse model.AIDS research and human retroviruses, 8 8
D. Sachs (1989)
Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimenThe Journal of Experimental Medicine, 169
S. Ildstad, S. Wren, S. Boggs, M. Hronakes, F. Vecchini, M. Brink (1991)
Cross-species bone marrow transplantation: evidence for tolerance induction, stem cell engraftment, and maturation of T lymphocytes in a xenogeneic stromal environment (rat----mouse)The Journal of Experimental Medicine, 174
A. El-Ezz, S. Wren, C. Kaufman, C. Ricordi, C. Haluszczak, S. Ildstad (1992)
Sublethal irradiation: a nonlethal method to achieve cross-species chimerism (rat-->mouse).Transplantation proceedings, 24 6
D. Ashany, J. Hines, A. Gharavi, J. Mouradian, K. Elkon (1992)
Analysis of autoantibody production in SCID‐systemic lupus erythematosus (SLE) chimerasClinical & Experimental Immunology, 88
Greenman Greenman, Hogg Hogg, Nikoletti Nikoletti, Slade Slade, Stevenson Stevenson, Glennie Glennie (1992)
Comparative efficiencies of bispecific F(ab′ gamma)2 and chimeric mouse/human IgG antibodies in recruiting cellular effectors for cytotoxicity via Fc gamma receptorsCancer Immunol Immunother, 34
Roland Carlsson, C. Mårtensson, S. Kalliomäki, Mats Ohlin, Carl Borrebaeck (1992)
Human peripheral blood lymphocytes transplanted into SCID mice constitute an in vivo culture system exhibiting several parameters found in a normal humoral immune response and are a source of immunocytes for the production of human monoclonal antibodies.Journal of immunology, 148 4
Richard Markham, A. Donnenberg (1992)
Effect of donor and recipient immunization protocols on primary and secondary human antibody responses in SCID mice reconstituted with human peripheral blood mononuclear cellsInfection and Immunity, 60
M. Bosma, A. Carroll (1991)
The SCID mouse mutant: definition, characterization, and potential uses.Annual review of immunology, 9
S. Schönbeck, F. Padberg, R. Hohlfeld, H. Wekerle (1992)
Transplantation of thymic autoimmune microenvironment to severe combined immunodeficiency mice. A new model of myasthenia gravis.The Journal of clinical investigation, 90 1
M. Sykes, D. Sachs, I. Aksentijevich (1992)
Effect of natural antibody on xenogeneic bone marrow engraftment.Transplantation proceedings, 24 2
M. Abedi, B. Christensson, K. Islam, L. Hammarström, C. Smith (1992)
Immunoglobulin production in severe combined immunodeficient (SCID) mice reconstituted with human peripheral blood mononuclear cellsEuropean Journal of Immunology, 22
D. Mosier, R. Gulizia, S. Baird, Darcy Wilson (1988)
Transfer of a functional human immune system to mice with severe combined immunodeficiencyNature, 335
I. Aksentijevich, D. Sachs, M. Sykes (1991)
Natural antibodies can inhibit bone marrow engraftment in the rat----mouse species combination.Journal of immunology, 147 12
Cudkowicz Cudkowicz, Bennett Bennett (1971)
Peculiar immunobiology of bone marrow allografts: I. Graft rejection by irradiated re‐sponder miceJ Exp Med, 134
Curnow Curnow, Glennie Glennie, Stevenson Stevenson (1993)
The role of apoptosis in antibody‐dependent cellular cytotoxicityCancer Immunol Immunother, 36
R. Geller, F. Bach, M. Turman, P. Casali, J. Platt (1993)
EVIDENCE THAT POLYREACTIVE ANTIBODIES ARE DEPOSITED IN REJECTED DISCORDANT XENOGRAFTSTransplantation, 55
Abstract: Attempts to transfer human peripheral blood lymphocytes (hu‐PBL) into lethally irradiated mice resulted in limited engraftment in recipients lacking natural antibodies (nAb) and could not be achieved in immunologically normal mice. It has been proposed that nAb with antihuman specificity play a major role in the rejection of the hu‐PBL graft. In the present study we demonstrate that, following intensification of the conditioning protocol (thymectomy, supralethal dose of TBI, and radioprotection with bone marrow for donors with severe combined immune deficiency (SCID), transplants of 50 to 70 × 106 hu‐PBL were successfully engrafted in BALB/c, CBA/J and C3H/HeJ mice—regardless of the initial high levels of nAb. The percentage of human CD45+ cells in peritoneal lavage was not statistically different from that obtained in congenitally immune‐deficient corresponding strains (SCID and CBA/N) lacking natural antibodies. Significant differences in engraftment of hu‐PBL, between different human donors, were related neither to the nAb content (r = 0.29) nor to the ABO(H) blood group. The transfer of serum with high level of nAb into SCID and CBA/N mice or incubation of hu‐PBL in such a serum prior to implantation, did not impede the engraftment and did not decrease the production of human immunoglobulins. These data demonstrate that the presence of nAb in supralethally irradiated normal mice does not inhibit the engraftment of hu‐PBL, emphasizing the role of cellular mediated mechanisms in xenograft rejection.
Xenotransplantation – Wiley
Published: Feb 1, 1995
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.