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N ‐(4‐(dicyanomethylazo)phenyl)‐2‐saccharin‐2‐ylacetamide in the synthesis of pyridazine and pyrimidine derivatives

N ‐(4‐(dicyanomethylazo)phenyl)‐2‐saccharin‐2‐ylacetamide in the synthesis of pyridazine and... N‐(4‐(Dicyanomethylazo)phenyl)‐2‐saccharin‐2‐ylacetamide (2) proved to be a convenient precursor for the synthesis of a variety of pyridazine and pyrimidine derivatives 4a,b,6, and 7. Also a series of substituted pyrimidines 10–16 were prepared from the reaction of N‐(4‐(2‐amino‐1‐cyano‐2‐substitutedvinylazo)phenyl)‐2‐(saccharin‐2‐yl)acetamide 9a,b with different reagents via initial addition to either the cyano or amino group, followed by cyclization. Some of the synthesized heterocycles were screened for their biological activity. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 15:2–8, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10194 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Heteroatom Chemistry Wiley

N ‐(4‐(dicyanomethylazo)phenyl)‐2‐saccharin‐2‐ylacetamide in the synthesis of pyridazine and pyrimidine derivatives

Heteroatom Chemistry , Volume 15 (1) – Jan 1, 2004

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References (13)

Publisher
Wiley
Copyright
Copyright © 2003 Wiley Periodicals, Inc.
ISSN
1042-7163
eISSN
1098-1071
DOI
10.1002/hc.10194
Publisher site
See Article on Publisher Site

Abstract

N‐(4‐(Dicyanomethylazo)phenyl)‐2‐saccharin‐2‐ylacetamide (2) proved to be a convenient precursor for the synthesis of a variety of pyridazine and pyrimidine derivatives 4a,b,6, and 7. Also a series of substituted pyrimidines 10–16 were prepared from the reaction of N‐(4‐(2‐amino‐1‐cyano‐2‐substitutedvinylazo)phenyl)‐2‐(saccharin‐2‐yl)acetamide 9a,b with different reagents via initial addition to either the cyano or amino group, followed by cyclization. Some of the synthesized heterocycles were screened for their biological activity. © 2003 Wiley Periodicals, Inc. Heteroatom Chem 15:2–8, 2004; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10194

Journal

Heteroatom ChemistryWiley

Published: Jan 1, 2004

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