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Modern management of primary T‐cell immunodeficiencies

Modern management of primary T‐cell immunodeficiencies The study of human T‐cell PIDs with Mendelian inheritance has enabled the molecular characterization of important key functions and pathways in T‐cell biology. In most cases, T‐cell PIDs become apparent as combined T‐ and B‐cell deficiencies. Severe combined immunodeficiencies (SCIDs) are characterized by a complete lack of T‐cell development and, in some cases, a developmental block in other lymphoid lineages and manifest within the first year of life. Combined immunodeficiency syndromes (CIDs) result from hypomorphic mutations in typical SCID associated genes or from partial defects of T‐cell development and manifest later in childhood by increased susceptibility to infection often combined with disturbances in immune homeostasis, e.g., autoimmunity and increased incidence in lymphoproliferation. The discovery of mutations and characterization of the cellular changes that underlie lymphocyte defects and immune dysregulation have led to novel, specific, successful therapies for severe diseases which are often fatal if left untreated. Over the last few years, impressive progress has been made in understanding the disease mechanisms of T‐cell immunodeficiencies and in improving the long‐term outcomes of potentially curative treatments, including gene therapy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Modern management of primary T‐cell immunodeficiencies

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References (84)

Publisher
Wiley
Copyright
"Copyright © 2014 John Wiley & Sons A/S"
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/pai.12179
pmid
24383740
Publisher site
See Article on Publisher Site

Abstract

The study of human T‐cell PIDs with Mendelian inheritance has enabled the molecular characterization of important key functions and pathways in T‐cell biology. In most cases, T‐cell PIDs become apparent as combined T‐ and B‐cell deficiencies. Severe combined immunodeficiencies (SCIDs) are characterized by a complete lack of T‐cell development and, in some cases, a developmental block in other lymphoid lineages and manifest within the first year of life. Combined immunodeficiency syndromes (CIDs) result from hypomorphic mutations in typical SCID associated genes or from partial defects of T‐cell development and manifest later in childhood by increased susceptibility to infection often combined with disturbances in immune homeostasis, e.g., autoimmunity and increased incidence in lymphoproliferation. The discovery of mutations and characterization of the cellular changes that underlie lymphocyte defects and immune dysregulation have led to novel, specific, successful therapies for severe diseases which are often fatal if left untreated. Over the last few years, impressive progress has been made in understanding the disease mechanisms of T‐cell immunodeficiencies and in improving the long‐term outcomes of potentially curative treatments, including gene therapy.

Journal

Pediatric Allergy and Immunology – Wiley

Published: Jun 1, 2014

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