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Mitochondrial DNA polymorphisms in Italy; III. Population data from Sicily: a possible quantitation of maternal African ancestry

Mitochondrial DNA polymorphisms in Italy; III. Population data from Sicily: a possible... SUMMARY mtDNA polymorphisms were studied in a sample of 90 individuals of the Sicilian population using six restriction enzymes: HpaI, BamHI, HaeII, MspI, AvaII and HincII. (1) Three new patterns, for MspI, AvaII and HincII, have been detected. (2) At least two different mutations were found to account for both the AvaII morph 3 and the AvaII morph 9 as in many other Caucasian groups so far examined. (3) Seventeen types were found; of these six are new. The frequency (54.5%) of type 1–2 (2.1.1.1.1.2) is lower than in the rest of Italy whereas those of type 6‐2 (2.1.2.1.1.2) (10.0%) and type 18‐2 (2.3.1.4.9*.2) (12.2%) lie at the upper level of the Italian range. The 18‐derivative, type 57‐2 (2.3.1.4.13*.2), which is consistently found in all Italian samples, is present also among Sicilians with an incidence of 2.2%. (4) Of particular interest is that the HpaI‐3/AvaII‐3 complex, which is unique to groups of African ancestry, was found in Sicily at a frequency of 4.4%. For the first time an estimate of the amount of gene flow from Blacks to the Sicilian gene pool could be obtained. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Mitochondrial DNA polymorphisms in Italy; III. Population data from Sicily: a possible quantitation of maternal African ancestry

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References (30)

Publisher
Wiley
Copyright
Copyright © 1989 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1989.tb01784.x
Publisher site
See Article on Publisher Site

Abstract

SUMMARY mtDNA polymorphisms were studied in a sample of 90 individuals of the Sicilian population using six restriction enzymes: HpaI, BamHI, HaeII, MspI, AvaII and HincII. (1) Three new patterns, for MspI, AvaII and HincII, have been detected. (2) At least two different mutations were found to account for both the AvaII morph 3 and the AvaII morph 9 as in many other Caucasian groups so far examined. (3) Seventeen types were found; of these six are new. The frequency (54.5%) of type 1–2 (2.1.1.1.1.2) is lower than in the rest of Italy whereas those of type 6‐2 (2.1.2.1.1.2) (10.0%) and type 18‐2 (2.3.1.4.9*.2) (12.2%) lie at the upper level of the Italian range. The 18‐derivative, type 57‐2 (2.3.1.4.13*.2), which is consistently found in all Italian samples, is present also among Sicilians with an incidence of 2.2%. (4) Of particular interest is that the HpaI‐3/AvaII‐3 complex, which is unique to groups of African ancestry, was found in Sicily at a frequency of 4.4%. For the first time an estimate of the amount of gene flow from Blacks to the Sicilian gene pool could be obtained.

Journal

Annals of Human Genetics – Wiley

Published: May 1, 1989

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