Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

MicroRNAs as biomarkers for psychiatric disorders with a focus on autism spectrum disorder: Current progress in genetic association studies, expression profiling, and translational research

MicroRNAs as biomarkers for psychiatric disorders with a focus on autism spectrum disorder:... MicroRNAs (miRNAs) are a group of small noncoding RNA molecules, 18–25 nucleotides in length, which can negatively regulate gene expression at the post‐transcriptional level by binding to messenger RNAs. About half of all identified miRNAs in humans are expressed in the brain and display regulatory functions important for many biological processes related to the development of the central nervous system (CNS). Disruptions in miRNA biogenesis and miRNA‐target interaction have been related to CNS diseases, including psychiatric disorders. In this review, we focus on the role of miRNAs in autism spectrum disorder (ASD) and summarize recent findings about ASD‐associated genetic variants in miRNA genes, in miRNA biogenesis genes, and miRNA targets. We discuss deregulation of miRNA expression in ASD and functional validation of ASD‐related miRNAs in animal models. Including miRNAs in studies of ASD will contribute to our understanding of its etiology and pathogenesis and facilitate the discrimination between different disease subgroups. Autism Res 2017. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Autism Res 2017, 10: 1184–1203. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Autism Research Wiley

MicroRNAs as biomarkers for psychiatric disorders with a focus on autism spectrum disorder: Current progress in genetic association studies, expression profiling, and translational research

Hu, Yubin; Ehli, Erik A.; Boomsma, Dorret I.
Autism Research , Volume 10 (7) – Jul 1, 2017
Download PDF
20 pages

Loading next page...
 
/lp/wiley/micrornas-as-biomarkers-for-psychiatric-disorders-with-a-focus-on-PSLKULr92C

References (116)

Publisher
Wiley
Copyright
© 2017 International Society for Autism Research, Wiley Periodicals, Inc.
ISSN
1939-3792
eISSN
1939-3806
DOI
10.1002/aur.1789
pmid
28419777
Publisher site
See Article on Publisher Site

Abstract

MicroRNAs (miRNAs) are a group of small noncoding RNA molecules, 18–25 nucleotides in length, which can negatively regulate gene expression at the post‐transcriptional level by binding to messenger RNAs. About half of all identified miRNAs in humans are expressed in the brain and display regulatory functions important for many biological processes related to the development of the central nervous system (CNS). Disruptions in miRNA biogenesis and miRNA‐target interaction have been related to CNS diseases, including psychiatric disorders. In this review, we focus on the role of miRNAs in autism spectrum disorder (ASD) and summarize recent findings about ASD‐associated genetic variants in miRNA genes, in miRNA biogenesis genes, and miRNA targets. We discuss deregulation of miRNA expression in ASD and functional validation of ASD‐related miRNAs in animal models. Including miRNAs in studies of ASD will contribute to our understanding of its etiology and pathogenesis and facilitate the discrimination between different disease subgroups. Autism Res 2017. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Autism Res 2017, 10: 1184–1203. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.

Journal

Autism Research – Wiley

Published: Jul 1, 2017

Keywords: ; ; ; ; ; ; ;

There are no references for this article.