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Methacholine and adenosine 5′‐monophosphate (AMP) responsiveness, and the presence and degree of atopy in children with asthma

Methacholine and adenosine 5′‐monophosphate (AMP) responsiveness, and the presence and degree of... To cite this article: Suh DI, Lee JK, Kim CK, Koh YY. Methacholine and adenosine 5′‐monophosphate (AMP) responsiveness, and the presence and degree of atopy in children with asthma. Pediatr Allergy Immunol 2011; 22: e101–e106. The relationship between atopy and bronchial hyperresponsiveness (BHR), both key features of asthma, remains to be clarified. BHR is commonly evaluated by bronchial challenges using direct and indirect stimuli. The aim of this study was to investigate the degree of BHR to methacholine (direct stimulus) and adenosine 5′‐monophosphate (AMP) (indirect stimulus) according to the presence and degree of atopy in children with asthma. We performed a retrospective analysis of data from 120 children presenting with a diagnosis of asthma. These children were characterized by skin‐prick tests (SPTs), spirometry and bronchial challenges with methacholine and AMP. Atopy was defined by at least one positive reaction to SPTs, and its degree was measured using serum total IgE levels, number of positive SPTs and atopic scores (sum of graded wheal size). A provocative concentration causing a 20% decline in FEV1 (PC20) was determined for each challenge. Patients with atopy(n = 94) had a significantly lower AMP PC20 than non‐atopic patients (n = 26), whereas methacholine PC20 was not different between the two groups. Among the patients with atopy, there was no association between methacholine PC20 and any atopy parameter. In contrast, a significant association was found between AMP PC20 and the degree of atopy reflected in serum total IgE, number of positive SPTs and atopic scores (anova trend test, p = 0.002, 0.001, 0.003, respectively). AMP responsiveness was associated with the presence and degree of atopy, whereas such a relationship was not observed for methacholine responsiveness. These findings suggest that atopic status may be better reflected by bronchial responsiveness assessed by AMP than by methacholine. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Methacholine and adenosine 5′‐monophosphate (AMP) responsiveness, and the presence and degree of atopy in children with asthma

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References (34)

Publisher
Wiley
Copyright
Copyright © 2011 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/j.1399-3038.2010.01110.x
pmid
21342276
Publisher site
See Article on Publisher Site

Abstract

To cite this article: Suh DI, Lee JK, Kim CK, Koh YY. Methacholine and adenosine 5′‐monophosphate (AMP) responsiveness, and the presence and degree of atopy in children with asthma. Pediatr Allergy Immunol 2011; 22: e101–e106. The relationship between atopy and bronchial hyperresponsiveness (BHR), both key features of asthma, remains to be clarified. BHR is commonly evaluated by bronchial challenges using direct and indirect stimuli. The aim of this study was to investigate the degree of BHR to methacholine (direct stimulus) and adenosine 5′‐monophosphate (AMP) (indirect stimulus) according to the presence and degree of atopy in children with asthma. We performed a retrospective analysis of data from 120 children presenting with a diagnosis of asthma. These children were characterized by skin‐prick tests (SPTs), spirometry and bronchial challenges with methacholine and AMP. Atopy was defined by at least one positive reaction to SPTs, and its degree was measured using serum total IgE levels, number of positive SPTs and atopic scores (sum of graded wheal size). A provocative concentration causing a 20% decline in FEV1 (PC20) was determined for each challenge. Patients with atopy(n = 94) had a significantly lower AMP PC20 than non‐atopic patients (n = 26), whereas methacholine PC20 was not different between the two groups. Among the patients with atopy, there was no association between methacholine PC20 and any atopy parameter. In contrast, a significant association was found between AMP PC20 and the degree of atopy reflected in serum total IgE, number of positive SPTs and atopic scores (anova trend test, p = 0.002, 0.001, 0.003, respectively). AMP responsiveness was associated with the presence and degree of atopy, whereas such a relationship was not observed for methacholine responsiveness. These findings suggest that atopic status may be better reflected by bronchial responsiveness assessed by AMP than by methacholine.

Journal

Pediatric Allergy and Immunology – Wiley

Published: Feb 1, 2011

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