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R. V. Lenth, P. Buerkner, M. Herve, J. Love, H. Riebl, H. Singmann (2021)
emmeans: Estimated marginal means, aka least‐ squares means
A. Tempone, Daniel Pimenta, I. Lebrun, P. Sartorelli, N. Taniwaki, H. Andrade, M. Antoniazzi, C. Jared (2008)
Antileishmanial and antitrypanosomal activity of bufadienolides isolated from the toad Rhinella jimi parotoid macrogland secretion.Toxicon : official journal of the International Society on Toxinology, 52 1
E. Cabrera-Guzmán, M. Crossland, Gregory Brown, R. Shine (2013)
Larger Body Size at Metamorphosis Enhances Survival, Growth and Performance of Young Cane Toads (Rhinella marina)PLoS ONE, 8
J. Longcore, A. Pessier, D. Nichols (1999)
BATRACHOCHYTRIUM DENDROBATIDIS GEN. ET SP. NOV., A CHYTRID PATHOGENIC TO AMPHIBIANSMycologia, 91
V. Bókony, B. Üveges, Viktória Verebélyi, Nikolett Ujhegyi, Á. Móricz (2019)
Toads phenotypically adjust their chemical defences to anthropogenic habitat changeScientific Reports, 9
Zsanett Mikó, J. Ujszegi, Zoltán Gál, Z. Imrei, A. Hettyey (2015)
Choice of experimental venue matters in ecotoxicology studies: Comparison of a laboratory-based and an outdoor mesocosm experiment.Aquatic toxicology, 167
Jacinta Thornton, Dawn Tin, Brian Tin, Richard Powelll
Diseases of Aquatic Organisms Dis Aquat Org
J. Ujszegi, K. Ludányi, Á. M. Móricz, D. Krüzselyi, L. Drahos, T. Drexler, M. Z. Németh, J. Vörös, T. W. J. Garner, A. Hettyey (2021)
Exposure to Batrachochytrium dendrobatidis affects chemical defences in two anuran amphibians, Rana dalmatina and Bufo bufo, 21
Altwegg R. (2003)
872Evolution (N. Y), 57
Michel Ohmer, R. Cramp, Catherine Russo, C. White, C. Franklin (2017)
Skin sloughing in susceptible and resistant amphibians regulates infection with a fungal pathogenScientific Reports, 7
P. Daszak, A. Strieby, A. Cunningham, J. Longcore, Corrie Brown, D. Porter (2004)
Experimental evidence that the bullfrog (Rana catesbeiana) is a potential carrier of chytridiomycosis, an emerging fungal disease of amphibiansHerpetological Journal, 14
M. Chatfield, L. Brannelly, Matthew Robak, Layla Freeborn, S. Lailvaux, C. Richards‐Zawacki (2013)
Fitness Consequences of Infection by Batrachochytrium dendrobatidis in Northern Leopard Frogs (Lithobates pipiens)EcoHealth, 10
F. Brem, J. R. Mendelson, K. R. Lips (2007)
Field‐sampling protocol for Batrachochytrium dendrobatidis from living amphibians, using alcohol preserved swabs. Version 1.0 (18 July 2007). Electron. Doc. Access
Matthew Becker, Jenifer Walke, Shawna Cikanek, A. Savage, Nichole Mattheus, Celina Santiago, K. Minbiole, R. Harris, L. Belden, B. Gratwicke (2015)
Composition of symbiotic bacteria predicts survival in Panamanian golden frogs infected with a lethal fungusProceedings of the Royal Society B: Biological Sciences, 282
V. Bókony, Á. Móricz, Z. Tóth, Zoltán Gál, Anikó Kurali, Zsanett Mikó, Katalin Pásztor, Márk Szederkényi, Z. Tóth, J. Ujszegi, B. Üveges, D. Krüzselyi, R. Capon, H. Hoi, A. Hettyey (2016)
Variation in Chemical Defense Among Natural Populations of Common Toad, Bufo bufo, Tadpoles: the Role of Environmental FactorsJournal of Chemical Ecology, 42
Candelario Rodriguez, R. Ibáñez, L. Mojica, Michelle Ng, Carmenza Spadafora, Armando Durant-Archibold, Marcelino Gutiérrez (2021)
Bufadienolides from the Skin Secretions of the Neotropical Toad Rhinella alata (Anura: Bufonidae): Antiprotozoal Activity against Trypanosoma cruziMolecules, 26
L. Berger, A. Hyatt, R. Speare, J. Longcore (2005)
Life cycle stages of the amphibian chytrid Batrachochytrium dendrobatidis.Diseases of aquatic organisms, 68 1
F. Ezzet, J. C. Pinheiro (2007)
Pharmacometrics
R. Shine, J. Amiel, A. J. Munn, M. Stewart, A. L. Vyssotski, J. A. Lesku (2015)
Is “cooling then freezing” a humane way to kill amphibians and reptiles?, 4
R. C. Toledo, C. Jared (1995)
Cutaneous granular glands and amphibian venoms, 111
M. F. Benard, J. A. Fordyce (2003)
Are induced defenses costly? Consequences of predator‐induced defenses in western toads, Bufo boreas, 84
A. Schrauder, B. Schweiger, U. Buchholz, W. Haas, D. Sagebiel, A. Guignard, W. Hellenbrand (2006)
Laboratory Exposure to Influenza A H2N2, Germany, 2004–2005Emerging Infectious Diseases, 12
R. Altwegg, H. Reyer (2003)
PATTERNS OF NATURAL SELECTION ON SIZE AT METAMORPHOSIS IN WATER FROGS, 57
J. Varga, Maxwell Bui-Marinos, B. Katzenback (2019)
Frog Skin Innate Immune Defences: Sensing and Surviving PathogensFrontiers in Immunology, 9
Jordan Kueneman, D. Woodhams, William Treuren, Holly Archer, R. Knight, V. McKenzie (2015)
Inhibitory bacteria reduce fungi on early life stages of endangered Colorado boreal toads (Anaxyrus boreas)The ISME Journal, 10
J. Daly (1995)
The chemistry of poisons in amphibian skin.Proceedings of the National Academy of Sciences of the United States of America, 92 1
B. Scheele, F. Pasmans, L. Skerratt, L. Berger, A. Martel, W. Beukema, Aldemar Acevedo, P. Burrowes, Tamilie Carvalho, A. Catenazzi, I. Riva, M. Fisher, Sandra Flechas, C. Foster, Patricia Frías-Álvarez, T. Garner, B. Gratwicke, Juan Guayasamin, Mareike Hirschfeld, J. Kolby, T. Kosch, E. Marca, D. Lindenmayer, K. Lips, A. Longo, Raúl Maneyro, C. McDonald, J. Mendelson, Pablo Palacios-Rodríguez, G. Parra-Olea, C. Richards‐Zawacki, Mark‐Oliver Rödel, Sean Rovito, C. Soto-Azat, L. Toledo, J. Voyles, C. Weldon, S. Whitfield, M. Wilkinson, K. Zamudio, S. Canessa (2019)
Amphibian fungal panzootic causes catastrophic and ongoing loss of biodiversityScience, 363
C. Carey, J. Bruzgul, Lauren Livo, Margie Walling, K. Kuehl, Brenner Dixon, A. Pessier, R. Alford, K. Rogers (2006)
Experimental Exposures of Boreal Toads (Bufo boreas) to a Pathogenic Chytrid Fungus (Batrachochytrium dendrobatidis)EcoHealth, 3
K. Lips (2016)
Overview of chytrid emergence and impacts on amphibiansPhilosophical Transactions of the Royal Society B: Biological Sciences, 371
J. Ujszegi, Á. Móricz, D. Krüzselyi, A. Hettyey (2017)
Skin toxin production of toads changes during early ontogeny but is not adjusted to the microbiota of the aquatic environmentEvolutionary Ecology, 31
D. Woodhams, J. Bosch, C. Briggs, S. Cashins, Leyla Davis, A. Lauer, E. Muths, R. Puschendorf, B. Schmidt, B. Sheafor, J. Voyles (2011)
Mitigating amphibian disease: strategies to maintain wild populations and control chytridiomycosisFrontiers in Zoology, 8
P. Daszak, A. Cunningham, A. Hyatt (2000)
Emerging infectious diseases of wildlife--threats to biodiversity and human health.Science, 287 5452
S. O'Hanlon, A. Rieux, Rhys Farrer, G. Rosa, Bruce Waldman, A. Bataille, T. Kosch, K. Murray, B. Brankovics, Matteo Fumagalli, Michael Martin, N. Wales, M. Alvarado-Rybak, K. Bates, L. Berger, S. Böll, Lola Brookes, Frances Clare, Elodie Courtois, A. Cunningham, T. Doherty-Bone, Pria Ghosh, D. Gower, W. Hintz, J. Höglund, T. Jenkinson, Chun-Fu Lin, A. Laurila, A. Loyau, A. Martel, Sara Meurling, C. Miaud, P. Minting, F. Pasmans, D. Schmeller, B. Schmidt, Jennifer Shelton, L. Skerratt, Freya Smith, C. Soto-Azat, Matteo Spagnoletti, G. Tessa, L. Toledo, A. Valenzuela‐Sánchez, Ruhan Verster, J. Vörös, R. Webb, C. Wierzbicki, E. Wombwell, K. Zamudio, D. Aanensen, T. James, M. Gilbert, C. Weldon, J. Bosch, F. Balloux, T. Garner, M. Fisher (2018)
Recent Asian origin of chytrid fungi causing global amphibian declinesScience, 360
(2020)
R A Lang. Environ. Stat. Comput. R Found. Stat. Comput. Vienna, Australia
R. Bovo, D. Andrade, L. Toledo, A. Longo, D. Rodriguez, C. Haddad, K. Zamudio, C. Becker (2016)
Physiological responses of Brazilian amphibians to an enzootic infection of the chytrid fungus Batrachochytrium dendrobatidis.Diseases of aquatic organisms, 117 3
BB Rothermel, SC Walls, JC Mitchell, CK Dodd, LK Irwin, D. Green, VM Vazquez, JW Petranka, DJ Stevenson (2008)
Widespread occurrence of the amphibian chytrid fungus Batrachochytrium dendrobatidis in the southeastern USA.Diseases of aquatic organisms, 82 1
R. Hayes, M. Crossland, M. Hagman, R. Capon, R. Shine (2009)
Ontogenetic Variation in the Chemical Defenses of Cane Toads (Bufo marinus): Toxin Profiles and Effects on PredatorsJournal of Chemical Ecology, 35
Valarie Thomas, Yu Wang, P. Rooij, E. Verbrugghe, V. Baláž, J. Bosch, A. Cunningham, M. Fisher, T. Garner, M. Gilbert, E. Grasselli, Thierry Kinet, Arnaud Laudelout, S. Lötters, A. Loyau, C. Miaud, S. Salvidio, D. Schmeller, B. Schmidt, A. Sluijs, S. Steinfartz, M. Veith, M. Vences, Norman Wagner, S. Canessa, A. Martel, F. Pasmans (2019)
Mitigating Batrachochytrium salamandrivorans in EuropeAmphibia-Reptilia
Candelario Rodriguez, R. Ibáñez, L. Rollins‐Smith, Marcelino Gutiérrez, Armando Durant-Archibold (2020)
Antimicrobial Secretions of Toads (Anura, Bufonidae): Bioactive Extracts and Isolated Compounds against Human PathogensAntibiotics, 9
D. Woodhams, Hannelore Brandt, Simone Baumgartner, J. Kielgast, E. Küpfer, Ursina Tobler, Leyla Davis, B. Schmidt, C. Bel, Sandro Hodel, R. Knight, V. McKenzie (2014)
Interacting Symbionts and Immunity in the Amphibian Skin Mucosome Predict Disease Risk and Probiotic EffectivenessPLoS ONE, 9
L. Skerratt, L. Berger, R. Speare, S. Cashins, K. Mcdonald, A. Phillott, H. Hines, Nicole Kenyon (2007)
Spread of Chytridiomycosis Has Caused the Rapid Global Decline and Extinction of FrogsEcoHealth, 4
N. Pike (2011)
Using false discovery rates for multiple comparisons in ecology and evolution, 2
A. Martel, A. Sluijs, M. Blooi, W. Bert, R. Ducatelle, M. Fisher, A. Woeltjes, W. Bosman, K. Chiers, Franky Bossuyt, F. Pasmans (2013)
Batrachochytrium salamandrivorans sp. nov. causes lethal chytridiomycosis in amphibiansProceedings of the National Academy of Sciences, 110
Antony Gomes, B. Giri, A. Saha, Roshnara Mishra, Dasgupta Sc, A. Debnath, A. Gomes (2007)
Bioactive molecules from amphibian skin: their biological activities with reference to therapeutic potentials for possible drug development.Indian journal of experimental biology, 45 7
Geraldino Filho, C. Schwartz, I. Resck, M. Murta, S. Lemos, M. Castro, C. Kyaw, O. Pires, J. Leite, C. Bloch, E. Schwartz (2005)
Antimicrobial activity of the bufadienolides marinobufagin and telocinobufagin isolated as major components from skin secretion of the toad Bufo rubescens.Toxicon : official journal of the International Society on Toxinology, 45 6
A. Sluijs, A. Martel, Johan Asselberghs, Emma Bales, W. Beukema, M. Bletz, Lutz Dalbeck, E. Goverse, A. Kerres, Thierry Kinet, Kai Kirst, Arnaud Laudelout, Luis Fonte, A. Nöllert, Dagmar Ohlhoff, Joana Sabino-Pinto, B. Schmidt, J. Speybroeck, F. Spikmans, S. Steinfartz, M. Veith, M. Vences, Norman Wagner, F. Pasmans, S. Lötters (2016)
Expanding Distribution of Lethal Amphibian Fungus Batrachochytrium salamandrivorans in EuropeEmerging Infectious Diseases, 22
Whitney Holden, Shane Hanlon, D. Woodhams, Timothy Chappell, H. Wells, Samantha Glisson, V. McKenzie, R. Knight, M. Parris, L. Rollins‐Smith (2015)
Skin bacteria provide early protection for newly metamorphosed southern leopard frogs (Rana sphenocephala) against the frog-killing fungus, Batrachochytrium dendrobatidisBiological Conservation, 187
J. Van Buskirk (2012)
A protocol for mesocosm experiments [WWW Document]
A. Hettyey, B. Üveges, Á. Móricz, L. Drahos, R. Capon, J. Buskirk, Z. Tóth, V. Bókony (2019)
Predator-induced changes in the chemical defence of a vertebrate.The Journal of animal ecology
H. Cheatsazan, Ana Almedia, A. Russell, C. Bonneaud (2013)
Experimental evidence for a cost of resistance to the fungal pathogen, Batrachochytrium dendrobatidis, for the palmate newt, Lissotriton helveticusBMC Ecology, 13
Laura Grogan, L. Skerratt, L. Berger, S. Cashins, R. Trengove, J. Gummer (2018)
Chytridiomycosis causes catastrophic organism-wide metabolic dysregulation including profound failure of cellular energy pathwaysScientific Reports, 8
T. Garner, S. Walker, J. Bosch, S. Leech, J. Rowcliffe, A. Cunningham, M. Fisher (2009)
Life history tradeoffs influence mortality associated with the amphibian pathogen Batrachochytrium dendrobatidisOikos, 118
M. Hagman, R. Hayes, R. Capon, R. Shine (2009)
Alarm cues experienced by cane toad tadpoles affect post‐metamorphic morphology and chemical defencesFunctional Ecology, 23
G. Marantelli, L. Berger, R. Speare, L. Keegan (2004)
Distribution of the amphibian chytrid Batrachochytrium dendrobatidis and keratin during tadpole development, 10
V. Bókony, B. Üveges, Á. Móricz, A. Hettyey (2018)
Competition induces increased toxin production in toad larvae without allelopathic effects on heterospecific tadpolesFunctional Ecology, 32
V. Bókony, Zsanett Mikó, Á. Móricz, D. Krüzselyi, A. Hettyey (2017)
Chronic exposure to a glyphosate-based herbicide makes toad larvae more toxicProceedings of the Royal Society B: Biological Sciences, 284
J. Bielby, M. Fisher, Frances Clare, G. Rosa, T. Garner (2015)
Host species vary in infection probability, sub-lethal effects, and costs of immune response when exposed to an amphibian parasiteScientific Reports, 5
Laura Grogan, J. Robert, L. Berger, L. Berger, L. Skerratt, L. Skerratt, B. Scheele, J. Castley, David Newell, H. McCallum (2018)
Review of the Amphibian Immune Response to Chytridiomycosis, and Future DirectionsFrontiers in Immunology, 9
R. Shine, J. Amiel, A. Munn, M. Stewart, A. Vyssotski, John Lesku (2015)
BIO012179 1..4
L. Berger, R. Speare, P. Daszak, D. Green, A. Cunningham, C. Goggin, R. Slocombe, M. Ragan, A. Hyatt, K. Mcdonald, H. Hines, K. Lips, G. Marantelli, H. Parkes (1998)
Chytridiomycosis causes amphibian mortality associated with population declines in the rain forests of Australia and Central America.Proceedings of the National Academy of Sciences of the United States of America, 95 15
(1992)
Standard Methods for the Examination of Water and Wastewater
Laura Grogan, Josephine Humphries, J. Robert, C. Lanctôt, C. Nock, David Newell, H. McCallum (2020)
Immunological Aspects of ChytridiomycosisJournal of Fungi, 6
J. Ujszegi, B. Vajna, Á. Móricz, D. Krüzselyi, Kristóf Korponai, G. Krett, A. Hettyey (2020)
Relationships Between Chemical Defenses of Common Toad (Bufo bufo) Tadpoles and Bacterial Community Structure of their Natural Aquatic HabitatJournal of Chemical Ecology, 46
C. Briggs, R. Knapp, V. Vredenburg (2010)
Enzootic and epizootic dynamics of the chytrid fungal pathogen of amphibiansProceedings of the National Academy of Sciences, 107
B. Üveges, G. Fera, Á. Móricz, D. Krüzselyi, V. Bókony, A. Hettyey (2017)
Age- and environment-dependent changes in chemical defences of larval and post-metamorphic toadsBMC Evolutionary Biology, 17
K. Gosner (1960)
A simplified table for staging anuran embryos and larvae with notes on identificationHerpetologica, 16
E. König, O. Bininda‐Emonds, C. Shaw (2015)
The diversity and evolution of anuran skin peptidesPeptides, 63
Robert Brucker, R. Harris, Christian Schwantes, T. Gallaher, Devon Flaherty, Brianna Lam, K. Minbiole (2008)
Amphibian Chemical Defense: Antifungal Metabolites of the Microsymbiont Janthinobacterium lividum on the Salamander Plethodon cinereusJournal of Chemical Ecology, 34
R. Harris, Robert Brucker, Jenifer Walke, Matthew Becker, Christian Schwantes, Devon Flaherty, Brianna Lam, D. Woodhams, C. Briggs, V. Vredenburg, K. Minbiole (2009)
Skin microbes on frogs prevent morbidity and mortality caused by a lethal skin fungusThe ISME Journal, 3
A. D. Hyatt, D. G. Boyle, V. Olsen, D. B. Boyle, L. Berger, D. Obendorf, A. Dalton, K. Kriger, M. Hero, H. Hines, R. Phillott, R. Campbell, G. Marantelli, F. Gleason, A. Colling (2007)
Diagnostic assays and sampling protocols for the detection of Batrachochytrium dendrobatidis, 73
B. Üveges, Anna Basson, Á. Móricz, V. Bókony, A. Hettyey (2021)
Chemical defence effective against multiple enemies: Does the response to conspecifics alleviate the response to predators?Functional Ecology
L. Berger, R. Speare, L. Skerratt (2005)
Distribution of Batrachochytrium dendrobatidis and pathology in the skin of green tree frogs Litoria caerulea with severe chytridiomycosis.Diseases of aquatic organisms, 68 1
A. Martel, M. Blooi, C. Adriaensen, P. Rooij, W. Beukema, M. Fisher, Rhys Farrer, B. Schmidt, Ursina Tobler, K. Goka, K. Lips, Carly Muletz, K. Zamudio, J. Bosch, S. Lötters, E. Wombwell, E. Wombwell, T. Garner, A. Cunningham, A. Sluijs, S. Salvidio, R. Ducatelle, Kouki Nishikawa, T. Nguyen, J. Kolby, I. Bocxlaer, Franky Bossuyt, F. Pasmans (2014)
Recent introduction of a chytrid fungus endangers Western Palearctic salamandersScience, 346
V. Vredenburg, R. Knapp, Tate Tunstall, C. Briggs (2010)
Dynamics of an emerging disease drive large-scale amphibian population extinctionsProceedings of the National Academy of Sciences, 107
J. Voyles, Sam Young, L. Berger, C. Campbell, W. Voyles, A. Dinudom, D. Cook, R. Webb, R. Alford, L. Skerratt, R. Speare (2009)
Pathogenesis of Chytridiomycosis, a Cause of Catastrophic Amphibian DeclinesScience, 326
A. Tempone, Marcia Melhem, Frederico Prado, G. Motoie, R. Hiramoto, M. Antoniazzi, Célio Haddad, C. Jared (2007)
Amphibian secretions for drug discovery studies: A search for new antiparasitic and antifungal compoundsLetters in Drug Design & Discovery, 4
C. Macfoy, Douglas Danosus, Raj Sandit, T. Jones, H. Garraffo, T. Spande, J. Daly (2005)
Alkaloids of Anuran Skin: Antimicrobial Function?Zeitschrift für Naturforschung C, 60
Kelly Barnhart, Megan Forman, T. Umile, Jordan Kueneman, V. McKenzie, I. Salinas, K. Minbiole, D. Woodhams (2017)
Identification of Bufadienolides from the Boreal Toad, Anaxyrus boreas, Active Against a Fungal PathogenMicrobial Ecology, 74
R. Solís, G. Lobos, S. Walker, M. Fisher, J. Bosch (2010)
Presence of Batrachochytrium dendrobatidis in feral populations of Xenopus laevis in ChileBiological Invasions, 12
D. Boyle, Db Boyle, V. Olsen, J. Morgan, A. Hyatt (2004)
Rapid quantitative detection of chytridiomycosis (Batrachochytrium dendrobatidis) in amphibian samples using real-time Taqman PCR assay.Diseases of aquatic organisms, 60 2
T. Garner, J. Rowcliffe, M. Fisher (2011)
Climate change, chytridiomycosis or condition: an experimental test of amphibian survivalGlobal Change Biology, 17
B. T. Clarke (1997)
The natural history of Amphibian skin secretions, their normal functioning and potential medical applications, 72
Batrachochytrium dendrobatidis (Bd) causes chytridiomycosis, an infectious disease of amphibians, which has contributed to population declines in hundreds of species worldwide. Common toads (Bufo bufo) exhibit low resistance and relatively high tolerance to Bd infection, which may partly be attributable to bufadienolide toxins secreted in their granular skin glands. Bufadienolides are known to provide an effective defense against several pathogens, parasites, and predators. The toxin production of bufonids is a plastic trait, inducible by several environmental factors. Here, we experimentally infected juvenile common toads with Bd and investigated if the toadlets could clear the infection over time, whether the infection induced bufadienolide production, and whether the infection caused decreased body mass. We found that prevalence remained 100% throughout the entire experimental period, but infection intensity did not increase and it was significantly lower on day 30 than on day 20. At the same time, compared to controls, infected toadlets produced lesser amounts of bufadienolides and their body mass was also lower. These results suggest that although young toadlets may not be able to clear Bd infection on their own, they may be able to keep infection intensities under control. Nonetheless, even if toadlets do not succumb to the disease, the costs of chronic infection may still compromise their fitness.
Journal of Zoology – Wiley
Published: Jul 1, 2022
Keywords: Batrachochytrium dendrobatidis; bufadienolides; Bufo bufo; costs of infection; fungal pathogen; indirect effect
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