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Meta‐analysis of public perception toward xenotransplantation

Meta‐analysis of public perception toward xenotransplantation The shortage of donor organs for transplantation is an international problem. One promising option to meet the need is xenotransplantation (XTx; eg, pig‐to‐human). However, there are still questions surrounding XTx that must be answered before proceeding to clinical trials. The current work is a meta‐analysis of articles published between 1985 and 2019 to analyze the factors most strongly associated with agreement and opposition toward the procedure. Although 80% (41/51) of the published studies were related to the opinions of patients, only three provided sufficient data for analysis. Thus, the bulk of what we really know about attitudes toward XTx comes from students, stakeholders, and hospital staff. The findings suggest that, before proceeding from the laboratory to clinical trials, more directed research is necessary from individual programs to achieve sufficient understanding of the attitudes of patients and the broader public, and the level of risk that is acceptable to these groups. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Xenotransplantation Wiley

Meta‐analysis of public perception toward xenotransplantation

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References (49)

Publisher
Wiley
Copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
ISSN
0908-665X
eISSN
1399-3089
DOI
10.1111/xen.12583
Publisher site
See Article on Publisher Site

Abstract

The shortage of donor organs for transplantation is an international problem. One promising option to meet the need is xenotransplantation (XTx; eg, pig‐to‐human). However, there are still questions surrounding XTx that must be answered before proceeding to clinical trials. The current work is a meta‐analysis of articles published between 1985 and 2019 to analyze the factors most strongly associated with agreement and opposition toward the procedure. Although 80% (41/51) of the published studies were related to the opinions of patients, only three provided sufficient data for analysis. Thus, the bulk of what we really know about attitudes toward XTx comes from students, stakeholders, and hospital staff. The findings suggest that, before proceeding from the laboratory to clinical trials, more directed research is necessary from individual programs to achieve sufficient understanding of the attitudes of patients and the broader public, and the level of risk that is acceptable to these groups.

Journal

Xenotransplantation – Wiley

Published: Jul 1, 2020

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