Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Maternal Effect: An Additional Mechanism Maintaining Balanced Polymorphisms of Haemoglobinopathies?

Maternal Effect: An Additional Mechanism Maintaining Balanced Polymorphisms of Haemoglobinopathies? The malarial hypothesis presupposes that carriers of sickle cell trait and β‐thalassaemia are born in accordance with Mendelian inheritance and later favoured by an environmental factor. However, an eventual distortion favouring the transmission of the mutant allele is also a plausible hypothesis. The Mendelian proportion was tested in the progeny of 201 sickle cell trait (AS) and 138 β‐thalassaemia (AT) probands married to individuals with normal haemoglobin (AA). An excess of births of heterozygotes in the offspring of the 107 AS mothers (144 AS:89AA, χ2= 12.98; p < 0.001) and 95 AT mothers (117 AT:66 AA, χ2= 14.21; p < 0.001) married to homozygous normal fathers was observed, but not for births to the reverse parental combinations (103 AS: 101AA, χ2= 0.019; p = 0.89 and 57 AT:42 AA, χ2= 2.27; p = 0.13). Such data reveal a statistically significant maternal effect favouring the transmission of haemoglobin S and β‐thalassaemia alleles. Obviously, prezygotic and postzygotic mechanisms of distortion cannot be ignored and need further investigation. However, the selective embryonic survival of AS and AT conceptuses of heterozygotic mothers, with an excess of unrecognized very early embryonic deaths among the AA conceptuses is a very attractive hypothesis that should also be taken into consideration. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Maternal Effect: An Additional Mechanism Maintaining Balanced Polymorphisms of Haemoglobinopathies?

Download PDF
5 pages

Loading next page...
 
/lp/wiley/maternal-effect-an-additional-mechanism-maintaining-balanced-ckf3W2ZWh0

References (24)

Publisher
Wiley
Copyright
Copyright © 2003 Wiley Subscription Services
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1046/j.1529-8817.2003.00068.x
Publisher site
See Article on Publisher Site

Abstract

The malarial hypothesis presupposes that carriers of sickle cell trait and β‐thalassaemia are born in accordance with Mendelian inheritance and later favoured by an environmental factor. However, an eventual distortion favouring the transmission of the mutant allele is also a plausible hypothesis. The Mendelian proportion was tested in the progeny of 201 sickle cell trait (AS) and 138 β‐thalassaemia (AT) probands married to individuals with normal haemoglobin (AA). An excess of births of heterozygotes in the offspring of the 107 AS mothers (144 AS:89AA, χ2= 12.98; p < 0.001) and 95 AT mothers (117 AT:66 AA, χ2= 14.21; p < 0.001) married to homozygous normal fathers was observed, but not for births to the reverse parental combinations (103 AS: 101AA, χ2= 0.019; p = 0.89 and 57 AT:42 AA, χ2= 2.27; p = 0.13). Such data reveal a statistically significant maternal effect favouring the transmission of haemoglobin S and β‐thalassaemia alleles. Obviously, prezygotic and postzygotic mechanisms of distortion cannot be ignored and need further investigation. However, the selective embryonic survival of AS and AT conceptuses of heterozygotic mothers, with an excess of unrecognized very early embryonic deaths among the AA conceptuses is a very attractive hypothesis that should also be taken into consideration.

Journal

Annals of Human Genetics – Wiley

Published: Jan 1, 2003

There are no references for this article.