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J. Nicholson, J. Lindon, E. Holmes (1999)
'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data.Xenobiotica; the fate of foreign compounds in biological systems, 29 11
Sheila CohenS, Robert Rognstadg, Robert Shulmanl, Joseph Kat (1981)
A comparison of 13C nuclear magnetic resonance and 14C tracer studies of hepatic metabolism.The Journal of biological chemistry, 256 7
S. Cohen, R. Shulman (1980)
13C n.m.r. studies of gluconeogenesis in rat liver suspensions and perfused mouse livers.Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 289 1037
Caroline Cartlidge, M. U, Alzhraa Alkhatib, S. Taylor-Robinson (2017)
The utility of biomarkers in hepatocellular carcinoma: review of urine-based 1H-NMR studies – what the clinician needs to knowInternational Journal of General Medicine, 10
R. Moon, J. Richards (1973)
Determination of intracellular pH by 31P magnetic resonance.The Journal of biological chemistry, 248 20
Sadhana Kumari, S. Kumaran, V. Goyal, Raj Sharma, N. Sinha, S. Dwivedi, Achal Srivastava, N. Jagannathan (2020)
Identification of potential urine biomarkers in Idiopathic Parkinson's disease using NMR.Clinica chimica acta; international journal of clinical chemistry
T. Brown, D. Gadian, P. Garlick, G. Radda, P. Seeley, P. Styles (1978)
CREATINE KINASE ACTIVITIES IN SKELETAL AND CARDIAC MUSCLE MEASURED BY SATURATION TRANSFER NMR
E. Andrew, A. Bradbury, R. Eades (1958)
Nuclear Magnetic Resonance Spectra from a Crystal rotated at High SpeedNature, 182
(2023)
How to cite this article: Griffiths JR. Magnetic resonance spectroscopy ex vivo: A short historical review
S. Cohen, P. Glynn, R. Shulman (1981)
13C NMR study of gluconeogenesis from labeled alanine in hepatocytes from euthyroid and hyperthyroid rats.Proceedings of the National Academy of Sciences of the United States of America, 78 1
F. Brown, I. Campbell, P. Kuchel (1977)
Human erythrocyte metabolism studies by 1H spin echo NMRFEBS Letters, 82
M Milkevich, EA Browning, E James (2016)
Handbook of Magnetic Spectroscopy in Vivo: MRS Theory, Practice and Applications
J. Nicholson, J. Connelly, J. Lindon, E. Holmes (2002)
Metabonomics: a platform for studying drug toxicity and gene functionNature Reviews Drug Discovery, 1
S. Howells, R. Maxwell, A. Peet, J. Griffiths (1992)
An Investigation of Tumor 1H Nuclear Magnetic Resonance Spectra by the Application of Chemometric TechniquesMagnetic Resonance in Medicine, 28
TR Brown, DG Gadian, PB Garlick, GK Radda, PJ Seeley, P Styles (1978)
Frontiers of Biological Energetics: Electrons to Tissues
M. Dawson, M. Dawson, D. Gadian, D. Wilkie (1978)
Muscular fatigue investigated by phosphorus nuclear magnetic resonanceNature, 274
U. Séquin, A. Scott (1974)
Carbon-13 as a label in biosynthetic studies.Science, 186 4159
R. Iles (2008)
Nuclear magnetic resonance spectroscopy and genetic disorders.Current medicinal chemistry, 15 1
T. Henderson, A. Costello, A. Omachi (1974)
Phosphate metabolism in intact human erythrocytes: determination by phosphorus-31 nuclear magnetic resonance spectroscopy.Proceedings of the National Academy of Sciences of the United States of America, 71 6
P. Sehr, G. Radda (1977)
A model kidney transplant studied by phosphorus nuclear magnetic resonance.Biochemical and biophysical research communications, 77 1
R. Eakin, L. Morgan, C. Gregg, N. Matwiyoff (1972)
Carbon‐13 nuclear magnetic resonance spectroscopy of living cells and their metabolism of a specifically labeled 13C substrateFEBS Letters, 28
D. Gadian, M. Dawson, D. Wilkie (1977)
Contraction and recovery of living muscles studied by 31p nuclear magnetic resonanceThe Journal of Physiology, 267
P. Garlick, G. Radda, P. Seeley, B. Chance (1977)
Phosphorus NMR studies on perfused heart.Biochemical and biophysical research communications, 74 3
J. Katz, R. Rognstad (1967)
The labeling of pentose phosphate from glucose-14C and estimation of the rates of transaldolase, transketolase, the contribution of the pentose cycle, and ribose phosphate synthesis.Biochemistry, 6 7
A. Cho, J. Lau, Benjamin Geraghty, C. Cunningham, K. Keshari (2017)
Noninvasive Interrogation of Cancer Metabolism with Hyperpolarized 13C MRIThe Journal of Nuclear Medicine, 58
R lles, A. Hind, R. Chalmers (1985)
Use of proton nuclear magnetic resonance spectroscopy in detection and study of organic acidurias.Clinical chemistry, 31 11
Mengqian Yu, Ying Zhu, Qingwei Cong, Chunyan Wu (2017)
Metabonomics Research Progress on Liver DiseasesCanadian Journal of Gastroenterology & Hepatology, 2017
L. Raamsdonk, B. Teusink, D. Broadhurst, Nianshu Zhang, A. Hayes, Michael Walsh, J. Berden, Kevin Brindle, Douglas Kell, J. Rowland, Hans Westerhoff, K. Dam, Stephen Oliver (2001)
A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutationsNature Biotechnology, 19
T. Conlon, R. Outhred (1972)
Water diffusion permeability of erythrocytes using an NMR technique.Biochimica et biophysica acta, 288 2
I. Jalloh, K. Carpenter, A. Helmy, T. Carpenter, D. Menon, P. Hutchinson (2014)
Glucose metabolism following human traumatic brain injury: methods of assessment and pathophysiological findingsMetabolic Brain Disease, 30
K. Behar, J. Hollander, M. Stromski, T. Ogino, R. Shulman, O. Petroff, J. Prichard (1983)
High-resolution 1H nuclear magnetic resonance study of cerebral hypoxia in vivo.Proceedings of the National Academy of Sciences of the United States of America, 80 16
O. Petroff, D. Spencer, J. Alger, J. Prichard (1989)
High‐field proton magnetic resonance spectroscopy of human cerebrum obtained during surgery for epilepsyNeurology, 39
I. Laíns, Daniela Duarte, António Barros, A. Martins, Tatiana Carneiro, J. Gil, John Miller, M. Marques, Tânia Mesquita, Patrícia Barreto, Ivana Kim, M. Cachulo, D. Vavvas, I. Carreira, J. Murta, Rufino Silva, Joan Miller, D. Husain, Ana Gil (2019)
Urine Nuclear Magnetic Resonance (NMR) Metabolomics in Age-Related Macular Degeneration.Journal of proteome research, 18 3
K. Brindle, F. Brown, I. Campbell, C. Grathwohl, P. Kuchel (1979)
Application of spin-echo nuclear magnetic resonance to whole-cell systems. Membrane transport.The Biochemical journal, 180 1
(2016)
MRS of perfused cells, tissues and organs
Elita Defeo, Leo Cheng (2010)
Characterizing Human Cancer Metabolomics with ex vivo 1H HRMAS MRSTechnology in Cancer Research & Treatment, 9
T. Brown, K. Uğurbil, R. Shulman (1977)
31P nuclear magnetic resonance measurements of ATPase kinetics in aerobic Escherichia coli cells.Proceedings of the National Academy of Sciences of the United States of America, 74 12
D. Hoult, Stephen Busby, D. Gadian, G. Radda, R. Richards, P. Seeley (1974)
Observation of tissue metabolites using 31P nuclear magnetic resonanceNature, 252
(1996)
A multicentre trial on MR spectroscopy of human tissue biopsies
J. Nicholson, E. Holmes, J. Kinross, R. Burcelin, G. Gibson, W. Jia, S. Pettersson (2012)
Host-Gut Microbiota Metabolic InteractionsScience, 336
O. Beckonert, H. Keun, T. Ebbels, J. Bundy, E. Holmes, J. Lindon, J. Nicholson (2007)
Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extractsNature Protocols, 2
M. Julià-Sapé, J. Griffiths, Rosemary Tate, F. Howe, D. Acosta, G. Postma, J. Underwood, C. Majós, C. Arús (2015)
Classification of brain tumours from MR spectra: the INTERPRET collaboration and its outcomesNMR in Biomedicine, 28
S. Cohen, R. Shulman, A. McLaughlin (1979)
Effects of ethanol on alanine metabolism in perfused mouse liver studied by 13C NMR.Proceedings of the National Academy of Sciences of the United States of America, 76 10
Burt Ct, T. Glonek, M. Bárány (1976)
Analysis of phosphate metabolites, the intracellular pH, and the state of adenosine triphosphate in intact muscle by phosphorus nuclear magnetic resonance.The Journal of biological chemistry, 251 9
(1920)
Effects of fructose on the energy metabolism and acid-base status of the perfused starved rat liver. A 31P NMR study
Over the last half century, there have been several periods during which magnetic resonance spectroscopy (MRS) has been used ex vivo, for a variety of reasons, on samples such as microorganisms, cells, animal or human tissue, tissue extracts or biological fluids. These studies began in the days before the acronym MRS had been invented, when all such methods were still called nuclear magnetic resonance (NMR), and have extended to the present day. I will describe the historical development of NMR methods used ex vivo, their influences on the development of MRS in vivo, and their longer‐term uses. All the interpretations will be personal, based on what I saw, or discussed with colleagues at the time.
NMR in Biomedicine – Wiley
Published: Apr 1, 2023
Keywords: chemometrics; metabolomics; metabonomics; MRS ex vivo
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