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Magnetic resonance spectroscopy ex vivo: A short historical review

Magnetic resonance spectroscopy ex vivo: A short historical review Over the last half century, there have been several periods during which magnetic resonance spectroscopy (MRS) has been used ex vivo, for a variety of reasons, on samples such as microorganisms, cells, animal or human tissue, tissue extracts or biological fluids. These studies began in the days before the acronym MRS had been invented, when all such methods were still called nuclear magnetic resonance (NMR), and have extended to the present day. I will describe the historical development of NMR methods used ex vivo, their influences on the development of MRS in vivo, and their longer‐term uses. All the interpretations will be personal, based on what I saw, or discussed with colleagues at the time. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png NMR in Biomedicine Wiley

Magnetic resonance spectroscopy ex vivo: A short historical review

NMR in Biomedicine , Volume 36 (4) – Apr 1, 2023

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References (45)

Publisher
Wiley
Copyright
© 2023 John Wiley & Sons, Ltd.
ISSN
0952-3480
eISSN
1099-1492
DOI
10.1002/nbm.4740
Publisher site
See Article on Publisher Site

Abstract

Over the last half century, there have been several periods during which magnetic resonance spectroscopy (MRS) has been used ex vivo, for a variety of reasons, on samples such as microorganisms, cells, animal or human tissue, tissue extracts or biological fluids. These studies began in the days before the acronym MRS had been invented, when all such methods were still called nuclear magnetic resonance (NMR), and have extended to the present day. I will describe the historical development of NMR methods used ex vivo, their influences on the development of MRS in vivo, and their longer‐term uses. All the interpretations will be personal, based on what I saw, or discussed with colleagues at the time.

Journal

NMR in BiomedicineWiley

Published: Apr 1, 2023

Keywords: chemometrics; metabolomics; metabonomics; MRS ex vivo

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