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GREENING AP . Proinflammatory cytokines in acute asthma
B. Bradley, M. Azzawi, M. Jacobson, B. Assoufi, J. Collins, A. Irani, L. Schwartz, S. Durham, P. Jeffery, A. Kay (1991)
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ROCHE WR . ROBERTS . IA . Hoi ciAiL ST . Cellular events in thc bronchi in mild asthma and after bronchial provocation
Christoph Walker, Erhard Bode, Liesbeth Boer, T. Hansel, K. Blaser, J. Virchow (1992)
Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage.The American review of respiratory disease, 146 1
D. Broide, G. Gleich, Anthony Cuomo, David Coburn, Edward Federman, Lawrence Schwarte, S. Wasserman (1991)
Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway.The Journal of allergy and clinical immunology, 88 4
(1991)
Dynamic T-ccll changes in peripheral blood and bronchoalveolar lavage after antigenic bronchoprovocalion in asthmatics
A. Kay (1991)
Asthma and inflammation.The Journal of allergy and clinical immunology, 87 5
R. Gundel, C. Wegner, C. Torcellini, Cosmos Clarke, N. Haynes, R. Rothlein, C. Smith, L. Letts (1991)
Endothelial leukocyte adhesion molecule-1 mediates antigen-induced acute airway inflammation and late-phase airway obstruction in monkeys.The Journal of clinical investigation, 88 4
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CARROLL . M . WAL . L . S A . HOWAKTH PH , HOI . - GATE ST . Early ehanges in T - lymphocytes recovered by bronehoalveolar lavage after local allergen challenge of asthmatic airways
In order to study cell activation in peripheral blood on bronchial allergen provocation up to 24 h, we investigated 32 asthmatic children, sensitive to house‐dust mites. Six healthy young adult volunteers served as controls. Lymphocyte subsets (CD3, CD19, CD4, CDS) and activation markers (CD25‐T, HLADR‐T, CD23) in peripheral blood as well as soluble IL2‐R and soluble ICAM‐1 in scrum were evaluated. In terms of clinical reaction, 23 children exhibited a DAR, 6 an EAR, 6 a LAR and 3 children did not show a bronchoconstrictor response to allergen challenge with house‐dust mite extract (NAR). In comparison to controls, asthmatic children showed a significantly higher expression of CD23 on B‐lymphocytcs (p < 0.05). Other subsets were in the same range in both groups. After provocation there was a significant increase of CD4/CD8‐ratio only in asthmatic children. Serum levels of sIL2‐R were significantly higher in asthmatic children compared to controls at baseline as well as at 12 and 24 h after provocation, without variation during observation period, No differences were noted for SICAM‐1. Our results confirm the hypothesis that lymphocytes, as important cells in regulation of allergic immune response, are recruited into peripheral blood under allergen challenge conditions in sensitized asthmatic children.
Pediatric Allergy and Immunology – Wiley
Published: Nov 1, 1993
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