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Longitudinal development of thalamic and internal capsule microstructure in autism spectrum disorder

Longitudinal development of thalamic and internal capsule microstructure in autism spectrum disorder IntroductionThe thalamus is commonly referred to as the relay center of the brain because of its abundant connections with the cortex and involvement in multimodal sensory processing. Lesions of the thalamic nuclei have been associated with complex‐movement deficits [Lee & Marsden, ], somatosensory challenges [Graff‐Radford, Damasio, Yamada, Eslinger, & Damasio, ], and visuomotor impairments [Fabre & Buser, ]. Yet, we know very little about how the thalamus develops in autism spectrum disorder (ASD), a disorder in which sensorimotor symptoms are commonly reported [Baranek, Little, Diane Parham, Ausderau, & Sabatos‐DeVito, ; Fournier, Hass, Naik, Lodha, & Cauraugh, ; Ming, Brimacombe, & Wagner, ].A growing body of evidence has begun to implicate the thalamus in ASD neuropathology. While there is still uncertainty about whether there are volumetric abnormalities of the thalamus [see Herbert et al., ; Lin, Ni, Lai, Tseng, & Gau, ; Tamura, Kitamura, Endo, Hasegawa, & Someya, ; Tsatsanis et al., ; Waiter et al., ; or in contrast, Bigler et al., ; Hardan et al., ; Haznedar et al., ; Lange et al., ; Schuetze et al., ], functional magnetic resonance imaging studies have been more consistent in demonstrating patterns of atypical activation of sensorimotor thalamic networks in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Autism Research Wiley

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References (72)

Publisher
Wiley
Copyright
© 2018 International Society for Autism Research, Wiley Periodicals, Inc.
ISSN
1939-3792
eISSN
1939-3806
DOI
10.1002/aur.1909
Publisher site
See Article on Publisher Site

Abstract

IntroductionThe thalamus is commonly referred to as the relay center of the brain because of its abundant connections with the cortex and involvement in multimodal sensory processing. Lesions of the thalamic nuclei have been associated with complex‐movement deficits [Lee & Marsden, ], somatosensory challenges [Graff‐Radford, Damasio, Yamada, Eslinger, & Damasio, ], and visuomotor impairments [Fabre & Buser, ]. Yet, we know very little about how the thalamus develops in autism spectrum disorder (ASD), a disorder in which sensorimotor symptoms are commonly reported [Baranek, Little, Diane Parham, Ausderau, & Sabatos‐DeVito, ; Fournier, Hass, Naik, Lodha, & Cauraugh, ; Ming, Brimacombe, & Wagner, ].A growing body of evidence has begun to implicate the thalamus in ASD neuropathology. While there is still uncertainty about whether there are volumetric abnormalities of the thalamus [see Herbert et al., ; Lin, Ni, Lai, Tseng, & Gau, ; Tamura, Kitamura, Endo, Hasegawa, & Someya, ; Tsatsanis et al., ; Waiter et al., ; or in contrast, Bigler et al., ; Hardan et al., ; Haznedar et al., ; Lange et al., ; Schuetze et al., ], functional magnetic resonance imaging studies have been more consistent in demonstrating patterns of atypical activation of sensorimotor thalamic networks in

Journal

Autism ResearchWiley

Published: Jan 1, 2018

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