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Long‐term safety and efficacy of perinatal probiotic intervention: Evidence from a follow‐up study of four randomized, double‐blind, placebo‐controlled trials

Long‐term safety and efficacy of perinatal probiotic intervention: Evidence from a follow‐up... allergy; asthma; Bifidobacterium lactis Bb-12; Background: Societies worldwide are faced with a progressive increase in immune- ST11; Bifidobacterium longum BL999; child; mediated health problems such as allergic, autoimmune, and inflammatory diseases, as infant; Lactobacillus paracasei; Lactobacillus well as obesity. Perinatal administration of specific probiotic bacteria is an attractive rhamnosus GG; probiotics/administration and approach in reducing the risk of these conditions, but long-term efficacy and safety dosage; probiotics/therapeutic use data are lacking. The aim here was to evaluate the clinical benefit and long-term safety of specific probiotics administered during the perinatal period. Correspondence Methods: The probiotic strains used were Lactobacillus rhamnosus GG, Bifidobac- Krista Lundelin, Department of Paediatrics, Turku University Hospital, FI-20520 Turku, terium lactis Bb-12, Lactobacillus paracasei ST11, and Bifidobacterium longum BL999. Finland The children involved have subsequently undergone prospective long-term follow-up. Tel.: +358 2 313 0000 In addition to physical examination, data were collected by structured questionnaires Fax: +358 2 313 1460 on non-communicable diseases and continued probiotic use, and growth data from E-mail: krista.lundelin@tyks.fi welfare clinics and school nurses. Results: Altogether 303 mother–infant pairs were included in the analysis. Seventy-six Accepted for publication 22 October 2016 of 163 (47%) children receiving perinatal probiotics had developed allergic disease http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Long‐term safety and efficacy of perinatal probiotic intervention: Evidence from a follow‐up study of four randomized, double‐blind, placebo‐controlled trials

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References (30)

Publisher
Wiley
Copyright
Copyright © 2017 John Wiley & Sons A/S
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/pai.12675
pmid
27779809
Publisher site
See Article on Publisher Site

Abstract

allergy; asthma; Bifidobacterium lactis Bb-12; Background: Societies worldwide are faced with a progressive increase in immune- ST11; Bifidobacterium longum BL999; child; mediated health problems such as allergic, autoimmune, and inflammatory diseases, as infant; Lactobacillus paracasei; Lactobacillus well as obesity. Perinatal administration of specific probiotic bacteria is an attractive rhamnosus GG; probiotics/administration and approach in reducing the risk of these conditions, but long-term efficacy and safety dosage; probiotics/therapeutic use data are lacking. The aim here was to evaluate the clinical benefit and long-term safety of specific probiotics administered during the perinatal period. Correspondence Methods: The probiotic strains used were Lactobacillus rhamnosus GG, Bifidobac- Krista Lundelin, Department of Paediatrics, Turku University Hospital, FI-20520 Turku, terium lactis Bb-12, Lactobacillus paracasei ST11, and Bifidobacterium longum BL999. Finland The children involved have subsequently undergone prospective long-term follow-up. Tel.: +358 2 313 0000 In addition to physical examination, data were collected by structured questionnaires Fax: +358 2 313 1460 on non-communicable diseases and continued probiotic use, and growth data from E-mail: krista.lundelin@tyks.fi welfare clinics and school nurses. Results: Altogether 303 mother–infant pairs were included in the analysis. Seventy-six Accepted for publication 22 October 2016 of 163 (47%) children receiving perinatal probiotics had developed allergic disease

Journal

Pediatric Allergy and Immunology – Wiley

Published: Mar 1, 2017

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