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- Publisher
- Wiley
- Copyright
- Copyright © 1994 Wiley Subscription Services
- ISSN
- 1050-9631
- eISSN
- 1098-1063
- DOI
- 10.1002/hipo.450040503
- pmid
- 7889124
- Publisher site
- See Article on Publisher Site
Abstract
The mRNAs for two forms of glutamic acid decarboxylase (GAD65 and GAD67) were localized in the rat hippocampal formation by nonradioactive in situ hybridization methods with digoxigeninlabeled cRNA probes. Some neurons in all layers of the hippocampus and dentate gyrus were readily labeled for each GAD mRNA, and the patterns of labeling for GAD65 and GAD67 mRNAs were very similar. All major groups of previously described GAD‐and GABA‐containing neurons appeared to be labeled for each GAD mRNA. Such findings suggest that most GABA neurons in the hippocampal formation contain both GAD mRNAs. When the labeling of neurons in the hippocampal formation and cerebral cortex was compared in the same sections, the intensity of neuronal labeling for GAD67 mRNA was generally similar in the two regions. However, the intensity of labeling for GAD65 mRNA was generally stronger for many neurons in the hippocampal formation than for most neurons in the cerebral cortex. Neurons in the hilus of the dentate gyrus were particularly well labeled for GAD65.
Journal
Hippocampus – Wiley
Published: Jan 1, 1994
Keywords: ; ; ; ;