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Letter to the Editor

Letter to the Editor Are the intracellular cytokine profiles of cord blood T lymphocytes useful for detecting a high risk of asthma in the newborn? Despite the increasing prevalence of allergic diseases in children and young adults in western countries during recent years, all genetic and epidemiological studies, while suggesting an important role of inheritance from the mother, have failed to identify children's risk factors for the future development of respiratory allergy ( 1 ). Hagendorens and co‐workers conducted a prospective study on immunological markers in cord blood for the prediction of allergic diseases in children in a group of 33 healthy, full‐term newborn infants, 23 of whom were considered at risk for atopy ( 2 ). In the newborns from atopic (n = 23) and non‐atopic (n = 10) parents, they were unable to demonstrate differences in T‐lymphocyte sub‐populations and/or in the numbers of interleukin (IL)‐2, IL‐4, and interferon‐γ (IFN‐γ)‐producing T cells. The authors conclude that at present, no parameter other than atopic status of the child itself can be used to evaluate the predictive power of the potentially new markers for atopy. Unfortunately, they limited their evaluation of cytokine‐producing T lymphocytes to IL‐2, IL‐4, and IFN‐γ, and could not provide http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Letter to the Editor

Pediatric Allergy and Immunology , Volume 12 (4) – Aug 1, 2001
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References (9)

Publisher
Wiley
Copyright
Copyright © 2001 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1034/j.1399-3038.2001.0l094.x
Publisher site
See Article on Publisher Site

Abstract

Are the intracellular cytokine profiles of cord blood T lymphocytes useful for detecting a high risk of asthma in the newborn? Despite the increasing prevalence of allergic diseases in children and young adults in western countries during recent years, all genetic and epidemiological studies, while suggesting an important role of inheritance from the mother, have failed to identify children's risk factors for the future development of respiratory allergy ( 1 ). Hagendorens and co‐workers conducted a prospective study on immunological markers in cord blood for the prediction of allergic diseases in children in a group of 33 healthy, full‐term newborn infants, 23 of whom were considered at risk for atopy ( 2 ). In the newborns from atopic (n = 23) and non‐atopic (n = 10) parents, they were unable to demonstrate differences in T‐lymphocyte sub‐populations and/or in the numbers of interleukin (IL)‐2, IL‐4, and interferon‐γ (IFN‐γ)‐producing T cells. The authors conclude that at present, no parameter other than atopic status of the child itself can be used to evaluate the predictive power of the potentially new markers for atopy. Unfortunately, they limited their evaluation of cytokine‐producing T lymphocytes to IL‐2, IL‐4, and IFN‐γ, and could not provide

Journal

Pediatric Allergy and Immunology – Wiley

Published: Aug 1, 2001

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