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Lay Abstract

Lay Abstract Serotonin Hypothesis of Autism: Implications for Selective Serotonin Reuptake Inhibitor Use during Pregnancy Rebecca A. Harrington, Li‐Ching Lee, Rosa M. Crum, Andrew W. Zimmerman, and Irva Hertz‐Picciotto LAY ABSTRACT Serotonin is a substance found throughout the brain and body of interest in autism. This is due to repeated findings of elevated serotonin levels in the blood of approximately one third of children with autism, leading some to believe that problems with the serotonin system may explain the development of autism in some cases. Because serotonin is critical in early brain development, concerns have arisen regarding prenatal exposure to factors that influence serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs). This review examines evidence regarding the serotonin system and autism spectrum disorders (ASD), as well as what the literature has reported on the developmental effects of prenatal SSRI exposure. Possible ways in which SSRIs could affect the fetus during pregnancy and clinical implications are also discussed. The majority of studies conducted in infants and children suggest prenatal exposure to SSRIs does not affect neurodevelopment, but limitations in these studies argue for further research. The only published study on prenatal SSRI exposure and ASD found an increased risk with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Autism Research Wiley

Lay Abstract

Autism Research , Volume 6 (3) – Jun 1, 2013
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Publisher
Wiley
Copyright
Copyright © 2013 Wiley Periodicals, Inc., A Wiley Company
ISSN
1939-3792
eISSN
1939-3806
DOI
10.1002/aur.1305
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Abstract

Serotonin Hypothesis of Autism: Implications for Selective Serotonin Reuptake Inhibitor Use during Pregnancy Rebecca A. Harrington, Li‐Ching Lee, Rosa M. Crum, Andrew W. Zimmerman, and Irva Hertz‐Picciotto LAY ABSTRACT Serotonin is a substance found throughout the brain and body of interest in autism. This is due to repeated findings of elevated serotonin levels in the blood of approximately one third of children with autism, leading some to believe that problems with the serotonin system may explain the development of autism in some cases. Because serotonin is critical in early brain development, concerns have arisen regarding prenatal exposure to factors that influence serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs). This review examines evidence regarding the serotonin system and autism spectrum disorders (ASD), as well as what the literature has reported on the developmental effects of prenatal SSRI exposure. Possible ways in which SSRIs could affect the fetus during pregnancy and clinical implications are also discussed. The majority of studies conducted in infants and children suggest prenatal exposure to SSRIs does not affect neurodevelopment, but limitations in these studies argue for further research. The only published study on prenatal SSRI exposure and ASD found an increased risk with

Journal

Autism Research – Wiley

Published: Jun 1, 2013

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