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Lay Abstract

Lay Abstract White Matter and Visuospatial Processing in Autism: A Constrained Spherical Deconvolution Tractography Study Jane McGrath, Katherine Johnson, Erik O'Hanlon, Hugh Garavan, Louise Gallagher, and Alexander Leemans LAY ABSTRACT Numerous studies have reported that synchronization of brain activity (functional connectivity) is abnormal in individuals with autism spectrum disorders (ASDs). This abnormal functional connectivity may arise from the disrupted organization of brain white matter—the conduit for neural communication. The aim of this study was to examine the structural organization of major white matter pathways that are important in the processing of visual and spatial information. To do this, an advanced method of analyzing magnetic resonance imaging (MRI) data (constrained spherical deconvolution (CSD) based tractography) was used. This method has never previously been used in autism research and is important as it has a number of advantages over alternative methods of investigating brain white matter structure. Individuals with ASD and control participants completed a high‐quality diffusion‐weighted MRI scan. Two major white matter tracts were isolated using CSD‐based tractography in all participants. The structural organization of these tracts and the relationship between white matter structure and visuospatial information processing was examined. Relative to controls, individuals with ASD showed significant alteration of white http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Autism Research Wiley

Lay Abstract

Autism Research , Volume 6 (5) – Oct 1, 2013
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Publisher
Wiley
Copyright
Copyright © 2013 Wiley Periodicals, Inc., A Wiley Company
ISSN
1939-3792
eISSN
1939-3806
DOI
10.1002/aur.1346
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Abstract

White Matter and Visuospatial Processing in Autism: A Constrained Spherical Deconvolution Tractography Study Jane McGrath, Katherine Johnson, Erik O'Hanlon, Hugh Garavan, Louise Gallagher, and Alexander Leemans LAY ABSTRACT Numerous studies have reported that synchronization of brain activity (functional connectivity) is abnormal in individuals with autism spectrum disorders (ASDs). This abnormal functional connectivity may arise from the disrupted organization of brain white matter—the conduit for neural communication. The aim of this study was to examine the structural organization of major white matter pathways that are important in the processing of visual and spatial information. To do this, an advanced method of analyzing magnetic resonance imaging (MRI) data (constrained spherical deconvolution (CSD) based tractography) was used. This method has never previously been used in autism research and is important as it has a number of advantages over alternative methods of investigating brain white matter structure. Individuals with ASD and control participants completed a high‐quality diffusion‐weighted MRI scan. Two major white matter tracts were isolated using CSD‐based tractography in all participants. The structural organization of these tracts and the relationship between white matter structure and visuospatial information processing was examined. Relative to controls, individuals with ASD showed significant alteration of white

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Autism Research – Wiley

Published: Oct 1, 2013

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