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Lamellar corneal pig‐to‐rabbit xenotransplantation

Lamellar corneal pig‐to‐rabbit xenotransplantation To the Editor: In a recently published study carried out by Pan et al. [ 1 ], it was found that rejection of pig‐rhesus xenografts did not occur in lamellar corneal transplantation, even in the absence of immunosuppressant therapy. Thus, the investigators speculated that without corneal endothelium, the lamellar corneal xenografts would remain transparent. However, we have performed 10 porcine lamellar corneal grafts in rabbits by the methods described [ 1 ] and found that the grafts were invariably rejected within 4 weeks (19 to 28 days after transplantation) ( Fig. 1 ). Moreover, our grafts showed severe inflammatory infiltration (258 ± 10.2 cells/400× HPF) ( Fig. 1 ), whereas Pan et al. observed few inflammatory cells in the grafts (0.2 ± 0.4 cells/×100 HPF). 1 Clinical and histological appearances of pig‐to‐rabbit lamellar corneal xenografts. (A) post‐operative day 3, (B) day 7, (C) day 14, (D) day 21, (E) day 28; (F) hematoxylin‐eosin staining of cornea at post‐operative day 28. Magnification ×50. We address these discrepancies in two ways. We first wondered what caused the lamellar grafts of the porcine cornea to be rejected by the rabbits within 1 month while they were accepted by the rhesus monkeys http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Xenotransplantation Wiley

Lamellar corneal pig‐to‐rabbit xenotransplantation

Xenotransplantation , Volume 15 (3) – May 1, 2008

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References (6)

Publisher
Wiley
Copyright
Copyright © 2008 Blackwell Munksgaard
ISSN
0908-665X
eISSN
1399-3089
DOI
10.1111/j.1399-3089.2008.00469.x
pmid
18611228
Publisher site
See Article on Publisher Site

Abstract

To the Editor: In a recently published study carried out by Pan et al. [ 1 ], it was found that rejection of pig‐rhesus xenografts did not occur in lamellar corneal transplantation, even in the absence of immunosuppressant therapy. Thus, the investigators speculated that without corneal endothelium, the lamellar corneal xenografts would remain transparent. However, we have performed 10 porcine lamellar corneal grafts in rabbits by the methods described [ 1 ] and found that the grafts were invariably rejected within 4 weeks (19 to 28 days after transplantation) ( Fig. 1 ). Moreover, our grafts showed severe inflammatory infiltration (258 ± 10.2 cells/400× HPF) ( Fig. 1 ), whereas Pan et al. observed few inflammatory cells in the grafts (0.2 ± 0.4 cells/×100 HPF). 1 Clinical and histological appearances of pig‐to‐rabbit lamellar corneal xenografts. (A) post‐operative day 3, (B) day 7, (C) day 14, (D) day 21, (E) day 28; (F) hematoxylin‐eosin staining of cornea at post‐operative day 28. Magnification ×50. We address these discrepancies in two ways. We first wondered what caused the lamellar grafts of the porcine cornea to be rejected by the rabbits within 1 month while they were accepted by the rhesus monkeys

Journal

XenotransplantationWiley

Published: May 1, 2008

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