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Lack of correlation between soluble CD 14 and IL-6 in meningococcal septic shock Arranz E. Blanco-Quiros A. Soli's P. Garrote JA. Lack of correlation between soluble CDI4 and IL-6 in meningococcal septic shock Pediatr Allergy Immunol 1997: 8: 194^199. © Munksgaard 1997. Meningococcal sepsis is a good model to study the dynamic response of cytokines and other soluble factors in vivo in the early stages of the disease. Levels ot soluble CD 14, interleukin-6 (IL-6), IL-6 receptor (1L-6R). and C-reactive protein (CRP) have been measured in plasma from 26 children with septic .shock (nine of whom had disseminated intravascular coagulation) and from ten control children. All samples were collected at the onset, before treatment, and, when possible. 24 and 48 hours later. At admission, patients had significantly higher levels of lL-6(p<0.00l) and CRP (p<O.(X)l). and lower levels of IL-6R (p<().005) than normal controls. After 24 hours, there was a significant increase of sCD24 (p<0,05) and CRP (p<O,(X)l). Although IL-6 showed a progressive decline since the onset, its levels were always higher than controls. There was an inverse correlation between IL-6 and both IL-6R (p<O,(X) I) and CRP (p<0.0() I), probabiy due to the later increase of CRP Nevertheless,
Pediatric Allergy and Immunology – Wiley
Published: Nov 1, 1997
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