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Issue Information Extracellular amyloid plaques are characteristic of Alzheimer’s disease, with the plaques mainly consisting of amyloid-β (abeta) fragments. Extracellular enzymes are known to induce abeta aggregation (and subsequent plaque formation) by catalyzing the crosslinking of abeta proteins. Kanapathipillai and co- workers describe the effects of osmolyte molecules on extracellular enzyme-mediated abeta (1-42) peptide aggregation and oxidative stress. L-proline and betaine are shown to inhibit the abeta peptide aggregation/ fibril formation, toxicity and oxidative stress in brain endothelial cells promoted by transglutaminase and lysyl oxidase in vitro. (doi: 10.1002/pep2.24093) EDITOR-IN-CHIEF P. Balaram Gregg B. Fields Yong-beom Lim Fred Naider Indian Institute of Florida Atlantic Yonsei University College of Staten Island Hilary J. Crichton Science University Seoul, South Korea Staten Island, NY, U.S.A. Bangalore, India Boca Raton, FL, U.S.A. ASSOCIATE EDITOR Robin Offord George Barany Shiroh Futaki William D. Lubell Conor H. Doss The Mintaka University of Minnesota Kyoto University Université de Montréal Foundation for Medical Minneapolis, MN, U.S.A. Kyoto, Japan Montréal, Canada Research EXECUTIVE EDITORS Plan-les-Ouates, Annette G. Samuel H. Gellman Joel P. Schneider Switzerland Beck-Sickinger Radhakrishnan University of Wisconsin- Frederick, MD, U.S.A. University of Leipzig Mahalakshmi Madison Leipzig, Germany Indian Institute of Sheena Radford Madison, WI, U.S.A. Nuno Correia Santos http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Peptide Science Wiley

Issue Information

Peptide Science , Volume 110 (6) – Nov 1, 2018

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Publisher
Wiley
Copyright
© 2018 Wiley Periodicals, Inc.
eISSN
2475-8817
DOI
10.1002/pep2.24108
Publisher site
See Article on Publisher Site

Abstract

Extracellular amyloid plaques are characteristic of Alzheimer’s disease, with the plaques mainly consisting of amyloid-β (abeta) fragments. Extracellular enzymes are known to induce abeta aggregation (and subsequent plaque formation) by catalyzing the crosslinking of abeta proteins. Kanapathipillai and co- workers describe the effects of osmolyte molecules on extracellular enzyme-mediated abeta (1-42) peptide aggregation and oxidative stress. L-proline and betaine are shown to inhibit the abeta peptide aggregation/ fibril formation, toxicity and oxidative stress in brain endothelial cells promoted by transglutaminase and lysyl oxidase in vitro. (doi: 10.1002/pep2.24093) EDITOR-IN-CHIEF P. Balaram Gregg B. Fields Yong-beom Lim Fred Naider Indian Institute of Florida Atlantic Yonsei University College of Staten Island Hilary J. Crichton Science University Seoul, South Korea Staten Island, NY, U.S.A. Bangalore, India Boca Raton, FL, U.S.A. ASSOCIATE EDITOR Robin Offord George Barany Shiroh Futaki William D. Lubell Conor H. Doss The Mintaka University of Minnesota Kyoto University Université de Montréal Foundation for Medical Minneapolis, MN, U.S.A. Kyoto, Japan Montréal, Canada Research EXECUTIVE EDITORS Plan-les-Ouates, Annette G. Samuel H. Gellman Joel P. Schneider Switzerland Beck-Sickinger Radhakrishnan University of Wisconsin- Frederick, MD, U.S.A. University of Leipzig Mahalakshmi Madison Leipzig, Germany Indian Institute of Sheena Radford Madison, WI, U.S.A. Nuno Correia Santos

Journal

Peptide ScienceWiley

Published: Nov 1, 2018

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