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Is there a march from early food sensitization to later childhood allergic airway disease? Results from two prospective birth cohort studies

Is there a march from early food sensitization to later childhood allergic airway disease?... allergic rhinitis; asthma; atopy; food Background: The march from early aeroallergen sensitization to subsequent respiratory sensitization allergy is well established, but it is unclear whether early life food sensitization precedes and further increases risk of allergic airway disease. Correspondence Objective: To assess the association between food sensitization in the first 2 years of Shyamali C Dharmage, Allergy and Lung life and subsequent asthma and allergic rhinitis by age 10–12 years. Health Unit, Centre for Epidemiology and Methods: We used data from two independent cohorts: the high-risk Melbourne Biostatistics, Melbourne School of Atopic Cohort Study (MACS) (n = 620) and the population-based LISAplus Population and Global Health, The University (n = 3094). Food sensitization was assessed at 6, 12, and 24 months in MACS and of Melbourne, 207 Bouverie Street, Carlton, Vic. 3010, Australia. 24 months in LISAplus. Multiple logistic regressions were used to estimate associa- E-mail: s.dharmage@unimelb.edu.au tions between sensitization to food only, aeroallergen only, or both and allergic airway disease. *Equal senior authors. Results: When compared to non-sensitized children, sensitization to food only at 12 months in MACS and 24 months in LISAplus was associated with increased risk of Accepted for publication 1 September 2016 current asthma (aOR http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Is there a march from early food sensitization to later childhood allergic airway disease? Results from two prospective birth cohort studies

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References (49)

Publisher
Wiley
Copyright
Copyright © 2017 John Wiley & Sons A/S
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/pai.12651
pmid
27590890
Publisher site
See Article on Publisher Site

Abstract

allergic rhinitis; asthma; atopy; food Background: The march from early aeroallergen sensitization to subsequent respiratory sensitization allergy is well established, but it is unclear whether early life food sensitization precedes and further increases risk of allergic airway disease. Correspondence Objective: To assess the association between food sensitization in the first 2 years of Shyamali C Dharmage, Allergy and Lung life and subsequent asthma and allergic rhinitis by age 10–12 years. Health Unit, Centre for Epidemiology and Methods: We used data from two independent cohorts: the high-risk Melbourne Biostatistics, Melbourne School of Atopic Cohort Study (MACS) (n = 620) and the population-based LISAplus Population and Global Health, The University (n = 3094). Food sensitization was assessed at 6, 12, and 24 months in MACS and of Melbourne, 207 Bouverie Street, Carlton, Vic. 3010, Australia. 24 months in LISAplus. Multiple logistic regressions were used to estimate associa- E-mail: s.dharmage@unimelb.edu.au tions between sensitization to food only, aeroallergen only, or both and allergic airway disease. *Equal senior authors. Results: When compared to non-sensitized children, sensitization to food only at 12 months in MACS and 24 months in LISAplus was associated with increased risk of Accepted for publication 1 September 2016 current asthma (aOR

Journal

Pediatric Allergy and Immunology – Wiley

Published: Feb 1, 2017

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