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Abundant and inexpensive iron, readily catalyzed the oxidative tandem reactions of arylalkylketones and benzylamines using molecular oxygen as the green oxidant in one‐pot solvent‐free conditions. 2,4,6‐Triaryl pyridines containing a wide variety of functional groups are synthesized from easily available starting materials. The synthetic importance of this reaction protocol has been demonstrated by preparing topoisomerase I and II inhibitors, and other valuable pyridine derivatives. Key intermediates are isolated and a plausible mechanism has been proposed.
Asian Journal of Organic Chemistry – Wiley
Published: Sep 1, 2018
Keywords: ; ; ; ;
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