Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Iron‐Catalyzed Aerobic Oxidative Cleavage and Construction of C−N Bonds: A Facile Method for Synthesis of 2,4,6‐Trisubstituted Pyridines

Iron‐Catalyzed Aerobic Oxidative Cleavage and Construction of C−N Bonds: A Facile Method for... Abundant and inexpensive iron, readily catalyzed the oxidative tandem reactions of arylalkylketones and benzylamines using molecular oxygen as the green oxidant in one‐pot solvent‐free conditions. 2,4,6‐Triaryl pyridines containing a wide variety of functional groups are synthesized from easily available starting materials. The synthetic importance of this reaction protocol has been demonstrated by preparing topoisomerase I and II inhibitors, and other valuable pyridine derivatives. Key intermediates are isolated and a plausible mechanism has been proposed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Asian Journal of Organic Chemistry Wiley

Iron‐Catalyzed Aerobic Oxidative Cleavage and Construction of C−N Bonds: A Facile Method for Synthesis of 2,4,6‐Trisubstituted Pyridines

Loading next page...
 
/lp/wiley/iron-catalyzed-aerobic-oxidative-cleavage-and-construction-of-c-n-a7OuNyRUVU

References (62)

Publisher
Wiley
Copyright
© 2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN
2193-5807
eISSN
2193-5815
DOI
10.1002/ajoc.201800312
Publisher site
See Article on Publisher Site

Abstract

Abundant and inexpensive iron, readily catalyzed the oxidative tandem reactions of arylalkylketones and benzylamines using molecular oxygen as the green oxidant in one‐pot solvent‐free conditions. 2,4,6‐Triaryl pyridines containing a wide variety of functional groups are synthesized from easily available starting materials. The synthetic importance of this reaction protocol has been demonstrated by preparing topoisomerase I and II inhibitors, and other valuable pyridine derivatives. Key intermediates are isolated and a plausible mechanism has been proposed.

Journal

Asian Journal of Organic ChemistryWiley

Published: Sep 1, 2018

Keywords: ; ; ; ;

There are no references for this article.