Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Interleukin‐33 in the developing lung—Roles in asthma and infection

Interleukin‐33 in the developing lung—Roles in asthma and infection It has become increasingly clear that interleukin‐33 (IL‐33) plays a crucial role in initiation of type 2 immunity. The last decade of intense research has uncovered multiple mechanisms through which IL‐33 targets key effector cells of the allergic immune response. Recently, IL‐33 has been implicated in shaping the immune system of the lungs early in life, at a time which is crucial in the subsequent development of allergic asthma. In this review, we will address the current literature describing the role of IL‐33 in the healthy and diseased lung. In particular, we will focus on the evidence for IL‐33 in the development of immune responses in the lung, including the role of IL‐33–responsive immune cells that may explain susceptibility to allergic sensitization at a young age and the association between genetic variants of IL‐33 and asthma in humans. Finally, we will indicate areas for potential therapeutic modulation of the IL‐33 pathway. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Interleukin‐33 in the developing lung—Roles in asthma and infection

Download PDF
8 pages

Loading next page...
 
/lp/wiley/interleukin-33-in-the-developing-lung-roles-in-asthma-and-infection-pyfQ9j5Fhv

References (77)

Publisher
Wiley
Copyright
Copyright © 2019 John Wiley & Sons A/S
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/pai.13040
Publisher site
See Article on Publisher Site

Abstract

It has become increasingly clear that interleukin‐33 (IL‐33) plays a crucial role in initiation of type 2 immunity. The last decade of intense research has uncovered multiple mechanisms through which IL‐33 targets key effector cells of the allergic immune response. Recently, IL‐33 has been implicated in shaping the immune system of the lungs early in life, at a time which is crucial in the subsequent development of allergic asthma. In this review, we will address the current literature describing the role of IL‐33 in the healthy and diseased lung. In particular, we will focus on the evidence for IL‐33 in the development of immune responses in the lung, including the role of IL‐33–responsive immune cells that may explain susceptibility to allergic sensitization at a young age and the association between genetic variants of IL‐33 and asthma in humans. Finally, we will indicate areas for potential therapeutic modulation of the IL‐33 pathway.

Journal

Pediatric Allergy and Immunology – Wiley

Published: Aug 1, 2019

Keywords: ; ; ; ;

There are no references for this article.