Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Interfering factors to sensitivity and specificity of bronchial reactivity in children

Interfering factors to sensitivity and specificity of bronchial reactivity in children Bronchial reactivity to carbachol, estimated by the PD65, the provocation dose of inhaled carbachol inducing a 65% increase of baseline respiratory resistance, was measured in 355 asthmatic children (age 8.7 ± 2.6 years) and 149 healthy children (age 11.8 ± 2.3 years). The frequency distribution of PD65 snowed apart from 2 minima at 480 μg and 960 μg 2 significant peaks at 240 μg (p = 0.003) and 1200 μg (p = 0.01) to carbachol. reflecting a hyperreactive class (PD65 <480 μg), an intermediate class (481 ug < PD65 < 960 μg) and a normo‐reactive class (PD65 > 961 μg). The intermediate class is characterised by a considerable overlap between “health” and “disease”. However, taking into account the degree of air pollution in which healthy children are living (best related factor to specificity) and the type of initial lung function disorder in asthmatic children, (the MEF50 to be the best related factor for specificiy), weighed specificity and sensitivity improved from 64 to 88%. Evaluating bronchial responsiveness in children, such interfering factors should be strongly considered. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Interfering factors to sensitivity and specificity of bronchial reactivity in children

Loading next page...
 
/lp/wiley/interfering-factors-to-sensitivity-and-specificity-of-bronchial-g8dvI0G0M0

References (70)

Publisher
Wiley
Copyright
Copyright © 1993 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/j.1399-3038.1993.tb00090.x
Publisher site
See Article on Publisher Site

Abstract

Bronchial reactivity to carbachol, estimated by the PD65, the provocation dose of inhaled carbachol inducing a 65% increase of baseline respiratory resistance, was measured in 355 asthmatic children (age 8.7 ± 2.6 years) and 149 healthy children (age 11.8 ± 2.3 years). The frequency distribution of PD65 snowed apart from 2 minima at 480 μg and 960 μg 2 significant peaks at 240 μg (p = 0.003) and 1200 μg (p = 0.01) to carbachol. reflecting a hyperreactive class (PD65 <480 μg), an intermediate class (481 ug < PD65 < 960 μg) and a normo‐reactive class (PD65 > 961 μg). The intermediate class is characterised by a considerable overlap between “health” and “disease”. However, taking into account the degree of air pollution in which healthy children are living (best related factor to specificity) and the type of initial lung function disorder in asthmatic children, (the MEF50 to be the best related factor for specificiy), weighed specificity and sensitivity improved from 64 to 88%. Evaluating bronchial responsiveness in children, such interfering factors should be strongly considered.

Journal

Pediatric Allergy and ImmunologyWiley

Published: Nov 1, 1993

There are no references for this article.