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Interaction between smoking and the stromelysin‐1 (MMP3) gene 5A/6A promoter polymorphism and risk of coronary heart disease in healthy men

Interaction between smoking and the stromelysin‐1 (MMP3) gene 5A/6A promoter polymorphism and... Smoking is a major risk factor for coronary heart disease (CHD), but this risk may be modified by an individual's genotype. A common functional 5A/6A polymorphism in the promoter of the stromelysin‐1 (matrix metalloproteinase 3, MMP3) gene has been identified. The 6A allele has been consistently associated with faster progression of angiographically determined CHD, while the 5A allele has recently been associated with risk of acute myocardial infarction (MI) in patients with unstable angina. To date there has been no prospective study of the relationship of this genotype to CHD risk in smokers and non‐smokers. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Interaction between smoking and the stromelysin‐1 (MMP3) gene 5A/6A promoter polymorphism and risk of coronary heart disease in healthy men

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References (49)

Publisher
Wiley
Copyright
Copyright © 2002 Wiley Subscription Services
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1046/j.1469-1809.2002.00126.x
Publisher site
See Article on Publisher Site

Abstract

Smoking is a major risk factor for coronary heart disease (CHD), but this risk may be modified by an individual's genotype. A common functional 5A/6A polymorphism in the promoter of the stromelysin‐1 (matrix metalloproteinase 3, MMP3) gene has been identified. The 6A allele has been consistently associated with faster progression of angiographically determined CHD, while the 5A allele has recently been associated with risk of acute myocardial infarction (MI) in patients with unstable angina. To date there has been no prospective study of the relationship of this genotype to CHD risk in smokers and non‐smokers.

Journal

Annals of Human GeneticsWiley

Published: Jan 1, 2002

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