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Inhibition of mRNA synthesis in the hippocampus impairs consolidation and reconsolidation of spatial memory

Inhibition of mRNA synthesis in the hippocampus impairs consolidation and reconsolidation of... Using two different mRNA synthesis inhibitors, we show that blockade of hippocampal gene expression during restricted posttraining or postretrieval time windows hinders retention of long‐term spatial memory for the Morris water maze task, without affecting short‐term memory, nonspatial learning, or the functionality of the hippocampus. Our results indicate that spatial memory consolidation induces the activation of the hippocampal transcriptional machinery and suggest the existence of a gene expression‐dependent reconsolidation process that operates in the dorsal hippocampus at the moment of retrieval to stabilize the reactivated mnemonic trace. © 2007 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hippocampus Wiley

Inhibition of mRNA synthesis in the hippocampus impairs consolidation and reconsolidation of spatial memory

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References (119)

Publisher
Wiley
Copyright
Copyright © 2007 Wiley‐Liss, Inc.
ISSN
1050-9631
eISSN
1098-1063
DOI
10.1002/hipo.20362
pmid
17853412
Publisher site
See Article on Publisher Site

Abstract

Using two different mRNA synthesis inhibitors, we show that blockade of hippocampal gene expression during restricted posttraining or postretrieval time windows hinders retention of long‐term spatial memory for the Morris water maze task, without affecting short‐term memory, nonspatial learning, or the functionality of the hippocampus. Our results indicate that spatial memory consolidation induces the activation of the hippocampal transcriptional machinery and suggest the existence of a gene expression‐dependent reconsolidation process that operates in the dorsal hippocampus at the moment of retrieval to stabilize the reactivated mnemonic trace. © 2007 Wiley‐Liss, Inc.

Journal

HippocampusWiley

Published: Jan 1, 2008

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