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Department of Dermatology, Medical School Hannover, Germany. Christine Neumann, M.D., Department of Dermatology, Medical School Hannover, Ricklinger Strasse 5, 3000 Hannover 91, Germany. Key words: inhalant allergens - pathogenesis Received 10 June 1991 Accepted 10 June 1991 IgE in the pathogenesis of atopic dermatitis The term âatopyâ - which had been created by Coca in 1923 for allergic manifestations to environmental and food proteins (1) - was soon extended to the associated dermatitis ( 2 ) . The atopic condition is characterized by hyperproduction of IgE, including allergen-specific IgE. In humans, twin studies have shown that the capacity for excessive IgE production is genetically determined (3) and animal studies have clearly shown that the overall genetic regulation of the IgE responder phenotype involves the T-cell system and its lymphokines ( ) As will be discussed later, the magni4. tude of IgE responses in vivo may be determined to a large degree by the interaction and balance of IL-4-producing and IFN-y-producing T-cell subsets. Marsh and colleges have uncovered some of the mechanisms contributing to the genetic regulation of IgE synthesis. They studied the association between IgE production to individual allergens and various HLA haplotypes and have documented a highly
Pediatric Allergy and Immunology – Wiley
Published: May 1, 1991
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