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Inflammation markers and symptom activity in children with bronchial asthma. Influence of atopy and eczema

Inflammation markers and symptom activity in children with bronchial asthma. Influence of atopy... Background. Eosinophil cationic protein (ECP) has been reported to reflect the eosinophil inflammatory activity in asthma. However, the relative impact of asthma symptoms and atopic eczema upon serum (s)‐ECP in asthmatic children has not been established. Objectives. To examine s‐ECP levels and s‐myeloperoxidase (MPO) in relation to asthma symptoms and atopic eczema in asthmatic children. Methods. S‐ECP and s‐MPO were assessed in relation to symptom activity, lung function, exercise induced bronchoconstriction and bronchial responsiveness in 101 children; median age 9 years, range 1‐16 years; with moderate to severe asthma, admitted to Voksentoppen Center. Result. S‐ECP was significantly higher in children with persistent compared to episodic or no asthma symptoms in the past four weeks, S‐ECP was also higher in children with atopic compared to non‐atopic asthma, as well as in those with active compared to past history of no history of atopic eczema. SMPO was higher in children with persistent asthma symptoms, but did not differ in relation to atopy of eczema state. Persistent asthma symptoms had the greatest impact upon s‐ECP levels, followed by atopy and active eczema. Conclusion. S‐ECP may be used in assessing symptom activity in asthmatic children, but with the realisation that active eczema and the presence of atopy may also influence levels. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Inflammation markers and symptom activity in children with bronchial asthma. Influence of atopy and eczema

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References (54)

Publisher
Wiley
Copyright
Copyright © 1997 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/j.1399-3038.1997.tb00163.x
Publisher site
See Article on Publisher Site

Abstract

Background. Eosinophil cationic protein (ECP) has been reported to reflect the eosinophil inflammatory activity in asthma. However, the relative impact of asthma symptoms and atopic eczema upon serum (s)‐ECP in asthmatic children has not been established. Objectives. To examine s‐ECP levels and s‐myeloperoxidase (MPO) in relation to asthma symptoms and atopic eczema in asthmatic children. Methods. S‐ECP and s‐MPO were assessed in relation to symptom activity, lung function, exercise induced bronchoconstriction and bronchial responsiveness in 101 children; median age 9 years, range 1‐16 years; with moderate to severe asthma, admitted to Voksentoppen Center. Result. S‐ECP was significantly higher in children with persistent compared to episodic or no asthma symptoms in the past four weeks, S‐ECP was also higher in children with atopic compared to non‐atopic asthma, as well as in those with active compared to past history of no history of atopic eczema. SMPO was higher in children with persistent asthma symptoms, but did not differ in relation to atopy of eczema state. Persistent asthma symptoms had the greatest impact upon s‐ECP levels, followed by atopy and active eczema. Conclusion. S‐ECP may be used in assessing symptom activity in asthmatic children, but with the realisation that active eczema and the presence of atopy may also influence levels.

Journal

Pediatric Allergy and ImmunologyWiley

Published: Aug 1, 1997

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