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Inactivation of the dorsal hippocampus does not affect learning during exploration of a novel environment

Inactivation of the dorsal hippocampus does not affect learning during exploration of a novel... The conditioned cue preference (CCP) task was used to study the ability of rats to discriminate between spatial locations. Food‐deprived rats explored an eight‐arm radial maze with no food present (pre‐exposure). On subsequent days, they were alternately confined in one arm of the maze with food and in another arm with no food (training), followed by a preference test with no food present, to determine if they had learned to discriminate between the two arm locations. No injections were given during the two latter phases. With adjacent radial maze arms, rats given three 10‐min pre‐exposure sessions and four food‐pairing trials exhibited a preference for their food‐paired arms; rats not pre‐exposed did not exhibit this preference. Rats pre‐exposed 30 min after dorsal hippocampus injections of muscimol exhibited the preference. With widely separated maze arms, rats given two training trials with no pre‐exposure exhibited a preference for the food‐paired arm; rats that were given one pre‐exposure session did not. Rats pre‐exposed 30 min after dorsal hippocampus injections of muscimol did not exhibit the preference. The same intrahippocampal muscimol injections that failed to affect the influence of pre‐exposure on CCP learning with both arm configurations impaired win‐shift performance, a standard test of spatial learning. These findings suggest that a functional dorsal hippocampus is not required for the (incidental or latent) learning that occurs during unreinforced exploration of a novel environment. The information acquired during this activity subsequently produces a latent learning effect if it is used to discriminate between two ambiguous locations (adjacent arms) or a latent inhibition––like effect if it is used to discriminate between two unambiguous locations (separated maze arms). © 2005 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hippocampus Wiley

Inactivation of the dorsal hippocampus does not affect learning during exploration of a novel environment

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References (82)

Publisher
Wiley
Copyright
Copyright © 2005 Wiley Subscription Services
ISSN
1050-9631
eISSN
1098-1063
DOI
10.1002/hipo.20127
pmid
16187330
Publisher site
See Article on Publisher Site

Abstract

The conditioned cue preference (CCP) task was used to study the ability of rats to discriminate between spatial locations. Food‐deprived rats explored an eight‐arm radial maze with no food present (pre‐exposure). On subsequent days, they were alternately confined in one arm of the maze with food and in another arm with no food (training), followed by a preference test with no food present, to determine if they had learned to discriminate between the two arm locations. No injections were given during the two latter phases. With adjacent radial maze arms, rats given three 10‐min pre‐exposure sessions and four food‐pairing trials exhibited a preference for their food‐paired arms; rats not pre‐exposed did not exhibit this preference. Rats pre‐exposed 30 min after dorsal hippocampus injections of muscimol exhibited the preference. With widely separated maze arms, rats given two training trials with no pre‐exposure exhibited a preference for the food‐paired arm; rats that were given one pre‐exposure session did not. Rats pre‐exposed 30 min after dorsal hippocampus injections of muscimol did not exhibit the preference. The same intrahippocampal muscimol injections that failed to affect the influence of pre‐exposure on CCP learning with both arm configurations impaired win‐shift performance, a standard test of spatial learning. These findings suggest that a functional dorsal hippocampus is not required for the (incidental or latent) learning that occurs during unreinforced exploration of a novel environment. The information acquired during this activity subsequently produces a latent learning effect if it is used to discriminate between two ambiguous locations (adjacent arms) or a latent inhibition––like effect if it is used to discriminate between two unambiguous locations (separated maze arms). © 2005 Wiley‐Liss, Inc.

Journal

HippocampusWiley

Published: Jan 1, 2005

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