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In Vivo Processing of Ceria Nanoparticles inside Liver: Impact on Free‐Radical Scavenging Activity and Oxidative Stress

In Vivo Processing of Ceria Nanoparticles inside Liver: Impact on Free‐Radical Scavenging... The cytotoxicity of ceria ultimately lies in its electronic structure, which is defined by the crystal structure, composition, and size. Despite previous studies focused on ceria uptake, distribution, biopersistance, and cellular effects, little is known about its chemical and structural stability and solubility once sequestered inside the liver. Mechanisms will be presented that elucidate the in vivo transformation in the liver. In vivo processed ceria reveals a particle‐size effect towards the formation of ultrafines, which represent a second generation of ceria. A measurable change in the valence reduction of the second‐generation ceria can be linked to an increased free‐radical scavenging potential. The in vivo processing of the ceria nanoparticles in the liver occurs in temporal relation to the brain cellular and protein clearance responses that stem from the ceria uptake. This information is critical to establish a possible link between cellular processes and the observed in vivo transformation of ceria. The temporal linkage between the reversal of the pro‐oxidant effect (brain) and ceria transformation (liver) suggests a cause–effect relationship. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png ChemPlusChem Wiley

In Vivo Processing of Ceria Nanoparticles inside Liver: Impact on Free‐Radical Scavenging Activity and Oxidative Stress

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References (67)

Publisher
Wiley
Copyright
"Copyright © 2014 Wiley Subscription Services, Inc., A Wiley Company"
eISSN
2192-6506
DOI
10.1002/cplu.201402080
Publisher site
See Article on Publisher Site

Abstract

The cytotoxicity of ceria ultimately lies in its electronic structure, which is defined by the crystal structure, composition, and size. Despite previous studies focused on ceria uptake, distribution, biopersistance, and cellular effects, little is known about its chemical and structural stability and solubility once sequestered inside the liver. Mechanisms will be presented that elucidate the in vivo transformation in the liver. In vivo processed ceria reveals a particle‐size effect towards the formation of ultrafines, which represent a second generation of ceria. A measurable change in the valence reduction of the second‐generation ceria can be linked to an increased free‐radical scavenging potential. The in vivo processing of the ceria nanoparticles in the liver occurs in temporal relation to the brain cellular and protein clearance responses that stem from the ceria uptake. This information is critical to establish a possible link between cellular processes and the observed in vivo transformation of ceria. The temporal linkage between the reversal of the pro‐oxidant effect (brain) and ceria transformation (liver) suggests a cause–effect relationship.

Journal

ChemPlusChemWiley

Published: Aug 1, 2014

Keywords: ; ; ; ;

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