Access the full text.
Sign up today, get DeepDyve free for 14 days.
Marc Howard, H. Eichenbaum (2015)
Time and space in the hippocampusBrain Research, 1621
D. Olton, G. Wenk, R. Church, W. Meck (1988)
Attention and the frontal cortex as examined by simultaneous temporal processingNeuropsychologia, 26
Mostafa Safaie, M. Jurado-Parras, Stefania Sarno, Jordane Louis, Corane Karoutchi, L. Petit, Matthieu Pasquet, C. Eloy, David Robbe (2020)
Turning the body into a clock: Accurate timing is facilitated by simple stereotyped interactions with the environmentProceedings of the National Academy of Sciences, 117
J. Hales, Sarah Israel, Nicole Swann, J. Brewer (2009)
Dissociation of Frontal and Medial Temporal Lobe Activity in Maintenance and Binding of Sequentially Presented Paired AssociatesJournal of Cognitive Neuroscience, 21
R. Church, Marvin Deluty (1977)
Bisection of temporal intervals.Journal of experimental psychology. Animal behavior processes, 3 3
Benjamin Kraus, Robert Robinson, J. White, H. Eichenbaum, M. Hasselmo (2013)
Hippocampal “Time Cells”: Time versus Path IntegrationNeuron, 78
J. Raber, Antiño Allen, Sydney Weber, Ayanabha Chakraborti, J. Fike (2016)
Effect of behavioral testing on spine density of basal dendrites in the CA1 region of the hippocampus modulated by 56Fe irradiationBehavioural Brain Research, 302
H. Spencer (2016)
The Principles of Psychology - Vol. I
J. Hales, M. Schlesiger, J. Leutgeb, L. Squire, S. Leutgeb, R. Clark (2014)
Medial entorhinal cortex lesions only partially disrupt hippocampal place cells and hippocampus-dependent place memory.Cell reports, 9 3
(2021)
In the temporal organization of episodic memory, the hippocampus supports the experience of elapsed time
Arne Dietrich, J. Allen (1998)
Functional dissociation of the prefrontal cortex and the hippocampus in timing behavior.Behavioral neuroscience, 112 5
James Heys, D. Dombeck (2018)
Evidence for a sub-circuit in medial entorhinal cortex representing elapsed time during immobilityNature neuroscience, 21
R. Ivry (1996)
The representation of temporal information in perception and motor controlCurrent Opinion in Neurobiology, 6
Z. Tiganj, M. Jung, Jieun Kim, Marc Howard (2017)
Sequential Firing Codes for Time in Rodent Medial Prefrontal CortexCerebral Cortex, 27
C. Fortin, Nathalie Massé (1999)
Order information in short-term memory and time estimationMemory & Cognition, 27
Arne Dietrich, Joseph Allen, B. Bunnell (1997)
Is the hippocampus involved in temporal discrimination and the memory of short intervals?The International journal of neuroscience, 90 3-4
Russell Church, Warren Meck, John Gibbon (1994)
Application of scalar timing theory to individual trials.Journal of experimental psychology. Animal behavior processes, 20 2
A. Dede, J. Wixted, R. Hopkins, L. Squire (2016)
Autobiographical memory, future imagining, and the medial temporal lobeProceedings of the National Academy of Sciences, 113
J. Cassel, S. Cassel, R. Galani, C. Kelche, B. Will, L. Jarrard (1998)
Fimbria–Fornix vs Selective Hippocampal Lesions in Rats: Effects on Locomotor Activity and Spatial Learning and MemoryNeurobiology of Learning and Memory, 69
J. Sinden, J. Rawlins, J. Gray, L. Jarrard (1986)
Selective cytotoxic lesions of the hippocampal formation and DRL performance in rats.Behavioral neuroscience, 100 3
M. Matell, W. Meck (2004)
Cortico-striatal circuits and interval timing: coincidence detection of oscillatory processes.Brain research. Cognitive brain research, 21 2
K. Onoda, Erika Takahashi, S. Sakata (2003)
Event-related potentials in the frontal cortex, hippocampus, and cerebellum during a temporal discrimination task in rats.Brain research. Cognitive brain research, 17 2
Benjamin Kraus, Mark Brandon, Robert Robinson, Michael Connerney, M. Hasselmo, H. Eichenbaum (2015)
During Running in Place, Grid Cells Integrate Elapsed Time and Distance RunNeuron, 88
R. Clark, Nicola Broadbent, L. Squire (2005)
Impaired remote spatial memory after hippocampal lesions despite extensive training beginning early in lifeHippocampus, 15
J. Manns, Marc Howard, H. Eichenbaum (2007)
Gradual Changes in Hippocampal Activity Support Remembering the Order of EventsNeuron, 56
R. Hicks, G. Miller, M. Kinsbourne (1976)
Prospective and retrospective judgments of time as a function of amount of information processed.The American journal of psychology, 89 4
P. Gill, S. Mizumori, David Smith (2011)
Hippocampal episode fields develop with learningHippocampus, 21
C. MacDonald, K. Lepage, U. Eden, H. Eichenbaum (2011)
Hippocampal “Time Cells” Bridge the Gap in Memory for Discontiguous EventsNeuron, 71
E. Tulving (2002)
Episodic memory: from mind to brain.Annual review of psychology, 53
E. Pastalkova, V. Itskov, Asohan Amarasingham, György Buzsáki (2008)
Internally Generated Cell Assembly Sequences in the Rat HippocampusScience, 321
B. Young, N. McNaughton (2000)
Common Firing Patterns of Hippocampal Cells in a Differential Reinforcement of Low Rates of Response ScheduleThe Journal of Neuroscience, 20
V. Itskov, Asohan Amarasingham (2011)
Hippocampus Internally Generated Cell Assembly Sequences in the Rat
R. Ivry, S. Keele (1989)
Timing Functions of The CerebellumJournal of Cognitive Neuroscience, 1
Merle Paule, Warren Meck, Donald McMillan, G. McClure, Melissa Bateson, E. Popke, J. Chelonis, Sean Hinton (1999)
The use of timing behaviors in animals and humans to detect drug and/or toxicant effects.Neurotoxicology and teratology, 21 5
E. Tulving (1972)
Episodic and semantic memory
Warren Meck (1988)
Hippocampal function is required for feedback control of an internal clock's criterion.Behavioral neuroscience, 102 1
W. Meck, R. Church, M. Matell (2013)
Hippocampus, time, and memory--a retrospective analysis.Behavioral neuroscience, 127 5
C. MacDonald, Stephen Carrow, Ryan Place, H. Eichenbaum (2013)
Distinct Hippocampal Time Cell Sequences Represent Odor Memories in Immobilized RatsThe Journal of Neuroscience, 33
D. Kumaran, E. Maguire (2006)
An Unexpected Sequence of Events: Mismatch Detection in the Human HippocampusPLoS Biology, 4
C. MacDonald (2014)
Prospective and retrospective duration memory in the hippocampus: is time in the foreground or background?Philosophical Transactions of the Royal Society B: Biological Sciences, 369
Yi Shen, S. Redmond, B. Teh, Sheng-Jie Yan, Yan Wang, Lin Zhou, C. Budgeon, R. Eikelboom, M. Atlas, R. Dilley, M. Zheng, R. Marano (2013)
Scaffolds for tympanic membrane regeneration in rats.Tissue engineering. Part A, 19 5-6
J. Hales, James Brewer (2010)
Activity in the hippocampus and neocortical working memory regions predicts successful associative memory for temporally discontiguous eventsNeuropsychologia, 48
J. Gibbon, R. Church, W. Meck (1984)
Scalar Timing in MemoryAnnals of the New York Academy of Sciences, 423
W. Meck, R. Church, D. Olton (1984)
Hippocampus, time, and memory.Behavioral neuroscience, 98 1
W. James (1890)
The principles of psychology, 2
M. Jueptner, M. Rijntjes, Cornelius Weiller, J. Faiss, Dagmar Timmann, Stefan Mueller, Hans-Christoph Diener (1995)
Localization of a cerebellar timing process using PETNeurology, 45
R. Kesner (2005)
Temporal processing of information: the role of the medial prefrontal cortex and hippocampus: theoretical comment on Gilmartin and McEchron (2005).Behavioral neuroscience, 119 6
Nicola Broadbent, L. Squire, R. Clark (2006)
Reversible hippocampal lesions disrupt water maze performance during both recent and remote memory tests.Learning & memory, 13 2
N. Jacobs, T. Allen, Natalie Nguyen, N. Fortin (2013)
Critical Role of the Hippocampus in Memory for Elapsed TimeThe Journal of Neuroscience, 33
J. Ainge, Matthijs Meer, R. Langston, E. Wood (2007)
Exploring the role of context‐dependent hippocampal activity in spatial alternation behaviorHippocampus, 17
Soyun Kim, Maya Sapiurka, R. Clark, L. Squire (2013)
Contrasting effects on path integration after hippocampal damage in humans and ratsProceedings of the National Academy of Sciences, 110
M. Matell, W. Meck, C. Lustig (2005)
Not “just” a coincidence: Frontal‐striatal interactions in working memory and interval timingMemory, 13
W. Meck (1996)
Neuropharmacology of timing and time perception.Brain research. Cognitive brain research, 3 3-4
N. Fortin, Kara Agster, H. Eichenbaum (2002)
Critical role of the hippocampus in memory for sequences of eventsNature Neuroscience, 5
M. Sabariego, A. Schönwald, Brittney Boublil, D. Zimmerman, S. Ahmadi, Nailea Gonzalez, C. Leibold, R. Clark, J. Leutgeb, S. Leutgeb (2019)
Time Cells in the Hippocampus Are Neither Dependent on Medial Entorhinal Cortex Inputs nor Necessary for Spatial Working MemoryNeuron, 102
H. Lejeune, P. Maquet, M. Bonnet, L. Casini, A. Ferrara, F. Macar, V. Pouthas, M. Timsit-Berthier, F. Vidal (1997)
The basic pattern of activation in motor and sensory temporal tasks: positron emission tomography dataNeuroscience Letters, 235
Emily Mankin, Geoffrey Diehl, Fraser Sparks, S. Leutgeb, J. Leutgeb (2015)
Hippocampal CA2 Activity Patterns Change over Time to a Larger Extent than between Spatial ContextsNeuron, 85
W. Meck, Aimée Benson (2002)
Dissecting the Brain's Internal Clock: How Frontal–Striatal Circuitry Keeps Time and Shifts AttentionBrain and Cognition, 48
Space and time are both essential features of episodic memory, for which the hippocampus is critical (Howard & Eichenbaum, 2015). Spatial tasks have been used effectively to study the behavioral relevance of place cells. However, the behavioral paradigms utilized for the study of time cells have not used time duration as a variable that animals need to be aware of to solve the task. Therefore, the behavioral relevance of this cell firing is unclear. In order to directly study the role of the hippocampus in processing elapsed time, we created a novel time duration discrimination task. Rats learned to make a decision to turn left or right depending on the preceding tone duration (10 s, left turn; 20 s, right turn). Once the rats reached criterion performance of 90% correct on two out of three consecutive days, they received either an excitotoxic hippocampal lesion or a sham‐lesion surgery. After recovery, rats were tested to determine hippocampal involvement in discriminating time duration. Rats with hippocampal lesions performed at chance level on their first testing day postlesion, and they were impaired relative to the sham‐lesioned rats. Although the hippocampal‐lesioned rats began discriminating at above chance level, their performance never returned to criterion even with 50 days of postoperative testing. Furthermore, while sham rats showed no difference in the number of errors they made on 10‐ versus 20‐s delay trials, hippocampal lesion rats similarly improved their performance under the 10‐s delay condition, but not under the 20‐s delay condition. Results indicate that hippocampal lesions resulted in a selective impairment in discriminating elapsed time only during the longer delay trials. The implications of these results are discussed in relation to the limits of working‐memory capacity and to the role of sustained hippocampal time cell activity in memory performance depending on the perceived relevance of the delay period.
Hippocampus – Wiley
Published: Jan 1, 2021
Keywords: ; ; ; ; ;
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.