Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Improved estimate of the Gm‐Pi linkage

Improved estimate of the Gm‐Pi linkage BY T. GEDDE-DAHL J R , * P. J . L. COOK,t M. K. FAGERHOLS AND J. A. PIERCES * Genetics Laboratory, Norsk Hydro’s Institute for Cancer Research, Oslo t MRC Human Biochemical Genetics Unit, Galton Laboratory, University College London $ Blood Bank and Department of Immunohaematology , Ullevdl Hospital, Oslo 5 Pulmonary Disease Division, School of Medicine, Washington University, St Louis INTRODUCTION The original report of linkage between the Gm and Pi loci (immunoglobulinIgG heavy chains and a,-antitrypsin) was based on 68 doubly heterozygous parents with 247 informative children (Gedde-Dahlet al. 1972). The recombination fractions were 23 % for males and 27 yofor females with lod scores of 4.4 and 3.3 respectively. It was noticed that families segregating for Pi M Z had an apparently lower recombination fraction (male 11 yo, female 22 %) than those segregating for ‘non-Z’ Pi alleles (27 % and 30%). This possible difference was of interest because it had been shown that a substance immunologically indistinguishable from a,-antitrypsin ie present within the liver cells of Pi Z individuals (Sharp, 1971) and within some liver cells of most Pi M Z and Pi SZ individuals. This suggested that there might be a separate http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Human Genetics Wiley

Loading next page...
 
/lp/wiley/improved-estimate-of-the-gm-pi-linkage-QcbjwURiGn

References (12)

Publisher
Wiley
Copyright
Copyright © 1975 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0003-4800
eISSN
1469-1809
DOI
10.1111/j.1469-1809.1975.tb00106.x
Publisher site
See Article on Publisher Site

Abstract

BY T. GEDDE-DAHL J R , * P. J . L. COOK,t M. K. FAGERHOLS AND J. A. PIERCES * Genetics Laboratory, Norsk Hydro’s Institute for Cancer Research, Oslo t MRC Human Biochemical Genetics Unit, Galton Laboratory, University College London $ Blood Bank and Department of Immunohaematology , Ullevdl Hospital, Oslo 5 Pulmonary Disease Division, School of Medicine, Washington University, St Louis INTRODUCTION The original report of linkage between the Gm and Pi loci (immunoglobulinIgG heavy chains and a,-antitrypsin) was based on 68 doubly heterozygous parents with 247 informative children (Gedde-Dahlet al. 1972). The recombination fractions were 23 % for males and 27 yofor females with lod scores of 4.4 and 3.3 respectively. It was noticed that families segregating for Pi M Z had an apparently lower recombination fraction (male 11 yo, female 22 %) than those segregating for ‘non-Z’ Pi alleles (27 % and 30%). This possible difference was of interest because it had been shown that a substance immunologically indistinguishable from a,-antitrypsin ie present within the liver cells of Pi Z individuals (Sharp, 1971) and within some liver cells of most Pi M Z and Pi SZ individuals. This suggested that there might be a separate

Journal

Annals of Human GeneticsWiley

Published: Jul 1, 1975

There are no references for this article.