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M. Wallace (1972)
Reduction in recombination due to a deletion in a colony of wild mice.The Journal of heredity, 63 5
(1972)
Autosomal linkage between MORTON
(1972)
Acid starch gel electrophoresis for detection of alpha - l - antitrypsin variants ( Pi - types ) : outline of techniques employed currently
C. Smith (1959)
Some comments on the statistical methods used in linkage investigations.American journal of human genetics, 11
N. Morton (1956)
The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type.American journal of human genetics, 8 2
Sharp Sharp (1971)
Alpha‐1‐antitrypsin deficiencyHospital Practice, 5
P. Cook (1975)
The genetics of α1‐antitrypsin: a family study in England and ScotlandAnnals of Human Genetics, 38
80-90. organisms -a theory
(1960)
Origin of genetic variation: regulation of genetic recombination in the higher SHARP
A. Chapelle, J. Schröder, K. Stenstrand, J. Fellman, R. Herva, M. Saarni, I. Anttolainen, I. Tallila, L. Tervilä, L. Husa, Gustav Tallqvist, E. Robson, P. Cook, R. Sanger (1974)
Pericentric inversions of human chromosomes 9 and 10.American journal of human genetics, 26 6
Gedde‐Dahl Gedde‐Dahl, Faoerhol Faoerhol, Cook Cook, Noades Noades (1972)
Autosomal linkage between the Gm and Pi loci in manAnn. Hum. Genet., Lond., 35
Pandy Pandy (1972)
Origin of genetic variation: regulation of genetic recombination in the higher organisms ‐ a theoryTheoret. Appl. Genetics, 42
BY T. GEDDE-DAHL J R , * P. J . L. COOK,t M. K. FAGERHOLS AND J. A. PIERCES * Genetics Laboratory, Norsk Hydroâs Institute for Cancer Research, Oslo t MRC Human Biochemical Genetics Unit, Galton Laboratory, University College London $ Blood Bank and Department of Immunohaematology , Ullevdl Hospital, Oslo 5 Pulmonary Disease Division, School of Medicine, Washington University, St Louis INTRODUCTION The original report of linkage between the Gm and Pi loci (immunoglobulinIgG heavy chains and a,-antitrypsin) was based on 68 doubly heterozygous parents with 247 informative children (Gedde-Dahlet al. 1972). The recombination fractions were 23 % for males and 27 yofor females with lod scores of 4.4 and 3.3 respectively. It was noticed that families segregating for Pi M Z had an apparently lower recombination fraction (male 11 yo, female 22 %) than those segregating for ânon-Zâ Pi alleles (27 % and 30%). This possible difference was of interest because it had been shown that a substance immunologically indistinguishable from a,-antitrypsin ie present within the liver cells of Pi Z individuals (Sharp, 1971) and within some liver cells of most Pi M Z and Pi SZ individuals. This suggested that there might be a separate
Annals of Human Genetics – Wiley
Published: Jul 1, 1975
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