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Immunologic disturbances in cow's milk allergy, 1: delayed maturation of suppressor activity

Immunologic disturbances in cow's milk allergy, 1: delayed maturation of suppressor activity To assist in identifying pathogenetic mechanisms in different subtypes of cow's milk allergy (CMA), the function of immunoregulatory T‐lymphocytes was studied. The study population consisted of 23 patients, mean (95% confidence interval) age of 25. 6 (19. 5, 33. 6) months, who had challenge‐proven cow's milk allergy manifested with either skin (n=9) or gastrointestinal (n=14) symptoms; in addition, 13 age‐matched disease controls were studied. Patients with challenge‐proven CMA were rechallenged to establish whether they had acquired clinical tolerance to cow's milk. The suppressor activity of isolated lymphocytes was measured in vitro by a cell coculture at rechallenge and in 10/23 patients at diagnosis. At diagnosis, patients with CMA (n=10) showed a decreased mean (95% CI) suppressor activity, induced by either Concanavalin A, 7(‐2, 15)%, or cow's milk, 3(‐8, 14)% as compared with disease controls (n = 13), 19(15, 24)% and 24(17, 31)%; F = 7. 1, p = 0.004 and F = 6. 7, p = 0.005, respectively. At rechallenge the suppressor activity, induced both by Concanavalin A and cow's milk, reached the level of disease controls only in patients who had acquired clinical tolerance to cow's milk (n = 13/23), but not in those retaining CMA (n = 10/23). Our results indicate that the maturation of suppressor function is delayed in CMA, which might be of primary importance in the etiopathogenesis of CMA. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pediatric Allergy and Immunology Wiley

Immunologic disturbances in cow's milk allergy, 1: delayed maturation of suppressor activity

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References (41)

Publisher
Wiley
Copyright
Copyright © 1993 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0905-6157
eISSN
1399-3038
DOI
10.1111/j.1399-3038.1993.tb00091.x
Publisher site
See Article on Publisher Site

Abstract

To assist in identifying pathogenetic mechanisms in different subtypes of cow's milk allergy (CMA), the function of immunoregulatory T‐lymphocytes was studied. The study population consisted of 23 patients, mean (95% confidence interval) age of 25. 6 (19. 5, 33. 6) months, who had challenge‐proven cow's milk allergy manifested with either skin (n=9) or gastrointestinal (n=14) symptoms; in addition, 13 age‐matched disease controls were studied. Patients with challenge‐proven CMA were rechallenged to establish whether they had acquired clinical tolerance to cow's milk. The suppressor activity of isolated lymphocytes was measured in vitro by a cell coculture at rechallenge and in 10/23 patients at diagnosis. At diagnosis, patients with CMA (n=10) showed a decreased mean (95% CI) suppressor activity, induced by either Concanavalin A, 7(‐2, 15)%, or cow's milk, 3(‐8, 14)% as compared with disease controls (n = 13), 19(15, 24)% and 24(17, 31)%; F = 7. 1, p = 0.004 and F = 6. 7, p = 0.005, respectively. At rechallenge the suppressor activity, induced both by Concanavalin A and cow's milk, reached the level of disease controls only in patients who had acquired clinical tolerance to cow's milk (n = 13/23), but not in those retaining CMA (n = 10/23). Our results indicate that the maturation of suppressor function is delayed in CMA, which might be of primary importance in the etiopathogenesis of CMA.

Journal

Pediatric Allergy and Immunology – Wiley

Published: Nov 1, 1993

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