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childhood; hay fever; IL-33; polymorphisms; Background: IL-33 polymorphisms influence the susceptibility to asthma. IL-33 Tregs indirectly induces Th2-immune responses via dendritic cell activation, being important for development of atopic diseases. Furthermore, IL-33 upregulates regulatory T cells Correspondence (Tregs), which are critical for healthy immune homeostasis. This study investigates Bianca Schaub, LMU Munich, University associations between IL-33 polymorphisms during the development of childhood Children’s Hospital, Lindwurmstrasse 4, atopic diseases and underlying mechanisms including immune regulation of Tregs. D 80337, Munich, Germany Methods: Genotyping of IL-33-polymorphisms (rs928413, rs1342326) was performed Tel.: 0049-89-4400-57856 by MALDI-TOF-MS in 880 of 1133 PASTURE/EFRAIM children. In 4.5-year-old Fax: 0049-89-4400-54764 + high + E-mail: Bianca.Schaub@med.uni-muenchen. German PASTURE/EFRAIM children (n = 99), CD4 CD25 FOXP3 Tregs de were assessed by flow cytometry following 24-h incubation of PBMCs with PMA/ ionomycin, LPS or without stimuli (U). SOCS3, IL1RL1, TLR4 mRNA expression *These authors contributed equally to this and sST2 protein levels ex vivo were measured in PASTURE/EFRAIM children by work. real-time PCR or ELISA, respectively. Health outcomes (hay fever, asthma) were assessed by questionnaires at the age of 6 years. PASTURE Study group are listed in Results: rs928413 and rs1342326 were positively associated with hay fever (OR = 1.77,
Pediatric Allergy and Immunology – Wiley
Published: Nov 1, 2016
Keywords: ; ; ; ;
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